2F3T

Crystal Structure Of E.coli Guanylate Kinase In Complex With Ganciclovir monophosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004385	molecular_function	guanylate kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006163	biological_process	purine nucleotide metabolic process
A	0016301	molecular_function	kinase activity
A	0042802	molecular_function	identical protein binding
A	0046037	biological_process	GMP metabolic process
A	0046710	biological_process	GDP metabolic process
B	0004385	molecular_function	guanylate kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006163	biological_process	purine nucleotide metabolic process
B	0016301	molecular_function	kinase activity
B	0042802	molecular_function	identical protein binding
B	0046037	biological_process	GMP metabolic process
B	0046710	biological_process	GDP metabolic process
C	0004385	molecular_function	guanylate kinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006163	biological_process	purine nucleotide metabolic process
C	0016301	molecular_function	kinase activity
C	0042802	molecular_function	identical protein binding
C	0046037	biological_process	GMP metabolic process
C	0046710	biological_process	GDP metabolic process
D	0004385	molecular_function	guanylate kinase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006163	biological_process	purine nucleotide metabolic process
D	0016301	molecular_function	kinase activity
D	0042802	molecular_function	identical protein binding
D	0046037	biological_process	GMP metabolic process
D	0046710	biological_process	GDP metabolic process
E	0004385	molecular_function	guanylate kinase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006163	biological_process	purine nucleotide metabolic process
E	0016301	molecular_function	kinase activity
E	0042802	molecular_function	identical protein binding
E	0046037	biological_process	GMP metabolic process
E	0046710	biological_process	GDP metabolic process
F	0004385	molecular_function	guanylate kinase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006163	biological_process	purine nucleotide metabolic process
F	0016301	molecular_function	kinase activity
F	0042802	molecular_function	identical protein binding
F	0046037	biological_process	GMP metabolic process
F	0046710	biological_process	GDP metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LGP A 300

Chain	Residue
A	SER38
A	ARG42
A	ARG45
A	TYR54
A	GLU73
A	TYR82
A	THR84

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LGP A 301

Chain	Residue
B	ARG45
B	TYR54
B	GLU73
B	ALA75
B	VAL77
B	TYR82
B	THR84
B	SER38
B	ARG42

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LGP A 302

Chain	Residue
E	SER38
E	ARG42
E	ARG45
E	TYR54
E	GLU73
E	TYR82

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site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LGP A 303

Chain	Residue
F	SER38
F	ARG45
F	TYR54
F	GLU73
F	TYR82
F	HOH210
F	HOH211

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Functional Information from PROSITE/UniProt

site_id	PS00856
Number of Residues	18
Details	GUANYLATE_KINASE_1 Guanylate kinase-like signature. TTRqpRpgEvhGehYfFV

Chain	Residue	Details
A	THR40-VAL57

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ALA11
B	ALA11
C	ALA11
D	ALA11
E	ALA11
F	ALA11

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