2F3C

Crystal structure of infestin 1, a Kazal-type serineprotease inhibitor, in complex with trypsin

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004175	molecular_function	endopeptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006508	biological_process	proteolysis
E	0007586	biological_process	digestion
E	0008236	molecular_function	serine-type peptidase activity
E	0046872	molecular_function	metal ion binding
E	0097180	cellular_component	serine protease inhibitor complex
E	0097655	molecular_function	serpin family protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 239

Chain	Residue
E	TYR20
E	THR21
E	SER107
E	ALA108

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 240

Chain	Residue
E	VAL17
E	LYS140
E	SER141
E	SER142

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 I 103

Chain	Residue
I	TYR23
I	SER24
I	THR28
I	HOH112
E	THR144

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 241

Chain	Residue
E	ASN92
E	THR95
E	ASN97
E	ASN98
E	LYS154

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 242

Chain	Residue
E	GLU67
E	ASN69
E	VAL72
E	GLU74
E	GLU77
E	HOH261

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
E	VAL51-CYS56

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV

Chain	Residue	Details
E	ASP186-VAL197

---

site_id	PS00282
Number of Residues	24
Details	KAZAL_1 Kazal serine protease inhibitors family signature. CprvlHrvCgSdgntYsnpCtldC

Chain	Residue	Details
I	CYS8-CYS31

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
E	LYS58
E	LEU102
E	PRO195

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING:

Chain	Residue	Details
E	ILE70
E	VAL72
E	GLY75
E	ILE80
E	GLN189
E	SER192
E	PRO195

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
E	ASP99
E	HIS55

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
E	SER192
E	GLY193

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
E	SER192
E	GLY190

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
E	SER192
E	ASP99
E	HIS55

---

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
E	SER192
E	ASP99
E	HIS55
E	GLY190

---

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
E	SER192
E	GLY193
E	ASP99
E	HIS55

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