2F2O
Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000922 | cellular_component | spindle pole |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005819 | cellular_component | spindle |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0010880 | biological_process | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0030234 | molecular_function | enzyme regulator activity |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0060315 | biological_process | negative regulation of ryanodine-sensitive calcium-release channel activity |
| A | 0060316 | biological_process | positive regulation of ryanodine-sensitive calcium-release channel activity |
| B | 0000922 | cellular_component | spindle pole |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005819 | cellular_component | spindle |
| B | 0005829 | cellular_component | cytosol |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0010880 | biological_process | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| B | 0019904 | molecular_function | protein domain specific binding |
| B | 0030234 | molecular_function | enzyme regulator activity |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0060315 | biological_process | negative regulation of ryanodine-sensitive calcium-release channel activity |
| B | 0060316 | biological_process | positive regulation of ryanodine-sensitive calcium-release channel activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1001 |
| Chain | Residue |
| A | ASP20 |
| A | ASP22 |
| A | ASP24 |
| A | THR26 |
| A | GLU31 |
| A | HOH1050 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1002 |
| Chain | Residue |
| A | THR62 |
| A | GLU67 |
| A | HOH1085 |
| A | ASP56 |
| A | ASP58 |
| A | ASN60 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1003 |
| Chain | Residue |
| A | ASP93 |
| A | ASP95 |
| A | ASN97 |
| A | TYR99 |
| A | GLU104 |
| A | HOH1006 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1004 |
| Chain | Residue |
| A | ASP129 |
| A | ASP131 |
| A | ASP133 |
| A | GLN135 |
| A | GLU140 |
| A | HOH1007 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1001 |
| Chain | Residue |
| B | ASP20 |
| B | ASP22 |
| B | ASP24 |
| B | THR26 |
| B | GLU31 |
| B | HOH1058 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 1002 |
| Chain | Residue |
| B | ASP56 |
| B | ASP58 |
| B | ASN60 |
| B | THR62 |
| B | GLU67 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1003 |
| Chain | Residue |
| B | ASP93 |
| B | ASP95 |
| B | ASN97 |
| B | TYR99 |
| B | GLU104 |
| B | HOH1007 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1004 |
| Chain | Residue |
| B | ASP129 |
| B | ASP131 |
| B | ASP133 |
| B | GLN135 |
| B | GLU140 |
| B | HOH1010 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL |
| Chain | Residue | Details |
| A | ASP20-LEU32 | |
| A | ASP56-PHE68 | |
| A | ASP93-LEU105 | |
| A | ASP129-PHE141 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 |
| Chain | Residue | Details |
| A | LYS21 | |
| A | PHE68 | |
| A | LYS94 | |
| A | GLY96 | |
| A | GLY98 | |
| A | ILE100 | |
| A | LEU105 | |
| A | ILE130 | |
| A | GLY132 | |
| A | GLY134 | |
| A | VAL136 | |
| A | GLY23 | |
| A | PHE141 | |
| B | LYS21 | |
| B | GLY23 | |
| B | GLY25 | |
| B | ILE27 | |
| B | LEU32 | |
| B | ALA57 | |
| B | GLY59 | |
| B | GLY61 | |
| B | ILE63 | |
| A | GLY25 | |
| B | PHE68 | |
| B | LYS94 | |
| B | GLY96 | |
| B | GLY98 | |
| B | ILE100 | |
| B | LEU105 | |
| B | ILE130 | |
| B | GLY132 | |
| B | GLY134 | |
| B | VAL136 | |
| A | ILE27 | |
| B | PHE141 | |
| A | LEU32 | |
| A | ALA57 | |
| A | GLY59 | |
| A | GLY61 | |
| A | ILE63 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:7356670 |
| Chain | Residue | Details |
| A | ASP2 | |
| B | ASP2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P0DP23 |
| Chain | Residue | Details |
| A | ASP22 | |
| B | ASP22 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29 |
| Chain | Residue | Details |
| A | GLU45 | |
| B | GLU45 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P0DP23 |
| Chain | Residue | Details |
| A | GLU82 | |
| A | ALA102 | |
| B | GLU82 | |
| B | ALA102 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P0DP23 |
| Chain | Residue | Details |
| A | ASP95 | |
| B | ASP95 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P0DP23 |
| Chain | Residue | Details |
| A | ILE100 | |
| A | GLU139 | |
| B | ILE100 | |
| B | GLU139 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P0DP23 |
| Chain | Residue | Details |
| A | ASN111 | |
| B | ASN111 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P0DP23 |
| Chain | Residue | Details |
| A | LEU116 | |
| B | LEU116 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:9716384 |
| Chain | Residue | Details |
| A | ASP22 | |
| B | ASP22 |
