2EYZ
CT10-Regulated Kinase isoform II
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001784 | molecular_function | phosphotyrosine residue binding |
| A | 0001878 | biological_process | response to yeast |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0005159 | molecular_function | insulin-like growth factor receptor binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| A | 0007167 | biological_process | enzyme-linked receptor protein signaling pathway |
| A | 0008092 | molecular_function | cytoskeletal protein binding |
| A | 0008283 | biological_process | cell population proliferation |
| A | 0008360 | biological_process | regulation of cell shape |
| A | 0009966 | biological_process | regulation of signal transduction |
| A | 0014911 | biological_process | positive regulation of smooth muscle cell migration |
| A | 0015629 | cellular_component | actin cytoskeleton |
| A | 0016020 | cellular_component | membrane |
| A | 0016477 | biological_process | cell migration |
| A | 0017124 | molecular_function | SH3 domain binding |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0019900 | molecular_function | kinase binding |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0030036 | biological_process | actin cytoskeleton organization |
| A | 0030159 | molecular_function | signaling receptor complex adaptor activity |
| A | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| A | 0030971 | molecular_function | receptor tyrosine kinase binding |
| A | 0031594 | cellular_component | neuromuscular junction |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0032956 | biological_process | regulation of actin cytoskeleton organization |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0035020 | biological_process | regulation of Rac protein signal transduction |
| A | 0035022 | biological_process | positive regulation of Rac protein signal transduction |
| A | 0035591 | molecular_function | signaling adaptor activity |
| A | 0035728 | biological_process | response to hepatocyte growth factor |
| A | 0042169 | molecular_function | SH2 domain binding |
| A | 0042542 | biological_process | response to hydrogen peroxide |
| A | 0045309 | molecular_function | protein phosphorylated amino acid binding |
| A | 0045953 | biological_process | negative regulation of natural killer cell mediated cytotoxicity |
| A | 0046330 | biological_process | positive regulation of JNK cascade |
| A | 0048013 | biological_process | ephrin receptor signaling pathway |
| A | 0061045 | biological_process | negative regulation of wound healing |
| A | 0061847 | biological_process | response to cholecystokinin |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071560 | biological_process | cellular response to transforming growth factor beta stimulus |
| A | 0071732 | biological_process | cellular response to nitric oxide |
| A | 0072657 | biological_process | protein localization to membrane |
| A | 0097110 | molecular_function | scaffold protein binding |
| A | 0098698 | biological_process | postsynaptic specialization assembly |
| A | 1900026 | biological_process | positive regulation of substrate adhesion-dependent cell spreading |
| A | 1901652 | biological_process | response to peptide |
| A | 1902531 | biological_process | regulation of intracellular signal transduction |
| A | 1990090 | biological_process | cellular response to nerve growth factor stimulus |
| A | 1990314 | biological_process | cellular response to insulin-like growth factor stimulus |
| A | 1990782 | molecular_function | protein tyrosine kinase binding |
| A | 1990859 | biological_process | cellular response to endothelin |
| A | 2000145 | biological_process | regulation of cell motility |
| A | 2000146 | biological_process | negative regulation of cell motility |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 105 |
| Details | Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | Domain: {"description":"SH3 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00192","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 61 |
| Details | Domain: {"description":"SH3 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00192","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 52 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 15 |
| Details | Compositional bias: {"description":"Pro residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Proline switch","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by ABL1","evidences":[{"source":"PubMed","id":"17515907","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
