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2EYZ

CT10-Regulated Kinase isoform II

Functional Information from GO Data
ChainGOidnamespacecontents
A0001764biological_processneuron migration
A0001784molecular_functionphosphotyrosine residue binding
A0001878biological_processresponse to yeast
A0002685biological_processregulation of leukocyte migration
A0005159molecular_functioninsulin-like growth factor receptor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006357biological_processregulation of transcription by RNA polymerase II
A0006629biological_processlipid metabolic process
A0007167biological_processenzyme-linked receptor protein signaling pathway
A0008092molecular_functioncytoskeletal protein binding
A0008283biological_processcell population proliferation
A0008360biological_processregulation of cell shape
A0009966biological_processregulation of signal transduction
A0014911biological_processpositive regulation of smooth muscle cell migration
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0016358biological_processdendrite development
A0016477biological_processcell migration
A0017124molecular_functionSH3 domain binding
A0019899molecular_functionenzyme binding
A0019900molecular_functionkinase binding
A0019904molecular_functionprotein domain specific binding
A0021766biological_processhippocampus development
A0021987biological_processcerebral cortex development
A0030010biological_processestablishment of cell polarity
A0030036biological_processactin cytoskeleton organization
A0030159molecular_functionsignaling receptor complex adaptor activity
A0030674molecular_functionprotein-macromolecule adaptor activity
A0030971molecular_functionreceptor tyrosine kinase binding
A0031594cellular_componentneuromuscular junction
A0031625molecular_functionubiquitin protein ligase binding
A0032956biological_processregulation of actin cytoskeleton organization
A0032991cellular_componentprotein-containing complex
A0033628biological_processregulation of cell adhesion mediated by integrin
A0035020biological_processregulation of Rac protein signal transduction
A0035022biological_processpositive regulation of Rac protein signal transduction
A0035591molecular_functionsignaling adaptor activity
A0035685biological_processhelper T cell diapedesis
A0035728biological_processresponse to hepatocyte growth factor
A0038026biological_processreelin-mediated signaling pathway
A0042169molecular_functionSH2 domain binding
A0042542biological_processresponse to hydrogen peroxide
A0043087biological_processregulation of GTPase activity
A0045309molecular_functionprotein phosphorylated amino acid binding
A0045953biological_processnegative regulation of natural killer cell mediated cytotoxicity
A0046330biological_processpositive regulation of JNK cascade
A0046875molecular_functionephrin receptor binding
A0048013biological_processephrin receptor signaling pathway
A0050773biological_processregulation of dendrite development
A0060326biological_processcell chemotaxis
A0061045biological_processnegative regulation of wound healing
A0061847biological_processresponse to cholecystokinin
A0070062cellular_componentextracellular exosome
A0071560biological_processcellular response to transforming growth factor beta stimulus
A0071732biological_processcellular response to nitric oxide
A0072657biological_processprotein localization to membrane
A0097110molecular_functionscaffold protein binding
A0098698biological_processpostsynaptic specialization assembly
A0098749biological_processcerebellar neuron development
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
A1901652biological_processresponse to peptide
A1902531biological_processregulation of intracellular signal transduction
A1904395biological_processpositive regulation of skeletal muscle acetylcholine-gated channel clustering
A1990090biological_processcellular response to nerve growth factor stimulus
A1990314biological_processcellular response to insulin-like growth factor stimulus
A1990782molecular_functionprotein tyrosine kinase binding
A1990859biological_processcellular response to endothelin
A2000145biological_processregulation of cell motility
A2000146biological_processnegative regulation of cell motility
A2000404biological_processregulation of T cell migration
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Proline switch => ECO:0000250
ChainResidueDetails
APRO237

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
ChainResidueDetails
AALA2

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER40

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER41

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER74

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER83

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATYR108

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER125

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by ABL1 => ECO:0000269|PubMed:17515907
ChainResidueDetails
ATYR221

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ATYR239

224572

PDB entries from 2024-09-04

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