2ESB

Crystal structure of human DUSP18

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0004726	molecular_function	non-membrane spanning protein tyrosine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006338	biological_process	chromatin remodeling
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006470	biological_process	protein dephosphorylation
A	0008138	molecular_function	protein tyrosine/serine/threonine phosphatase activity
A	0016311	biological_process	dephosphorylation
A	0016791	molecular_function	phosphatase activity
A	0017017	molecular_function	MAP kinase tyrosine/serine/threonine phosphatase activity
A	0017018	molecular_function	myosin phosphatase activity
A	0030946	molecular_function	protein tyrosine phosphatase activity, metal-dependent
A	0033192	molecular_function	calmodulin-dependent protein phosphatase activity
A	0035335	biological_process	peptidyl-tyrosine dephosphorylation
A	0035970	biological_process	peptidyl-threonine dephosphorylation
A	0140791	molecular_function	histone H2AXS140 phosphatase activity
A	0140793	molecular_function	histone H2AXY142 phosphatase activity
A	0180004	molecular_function	RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
A	0180005	molecular_function	RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
A	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
A	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
A	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
A	1990439	molecular_function	MAP kinase serine/threonine phosphatase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT A 1001

Chain	Residue
A	THR24
A	LYS25
A	HIS123

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site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EPE A 1002

Chain	Residue
A	SER109
A	ARG110
A	HOH1063
A	HOH1152
A	ASP73
A	CYS104
A	ALA105
A	ALA106
A	GLY107
A	VAL108

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Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. LHCaaGvsRSA

Chain	Residue	Details
A	LEU102-ALA112

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160

Chain	Residue	Details
A	CYS104

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