2ESB
Crystal structure of human DUSP18
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0008138 | molecular_function | protein tyrosine/serine/threonine phosphatase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
| A | 0035335 | biological_process | peptidyl-tyrosine dephosphorylation |
| A | 0035970 | biological_process | peptidyl-threonine dephosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 1001 |
| Chain | Residue |
| A | THR24 |
| A | LYS25 |
| A | HIS123 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EPE A 1002 |
| Chain | Residue |
| A | SER109 |
| A | ARG110 |
| A | HOH1063 |
| A | HOH1152 |
| A | ASP73 |
| A | CYS104 |
| A | ALA105 |
| A | ALA106 |
| A | GLY107 |
| A | VAL108 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. LHCaaGvsRSA |
| Chain | Residue | Details |
| A | LEU102-ALA112 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 141 |
| Details | Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
