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2ERA

RECOMBINANT ERABUTOXIN A, S8G MUTANT

Functional Information from GO Data
ChainGOidnamespacecontents
A0005576cellular_componentextracellular region
A0030550molecular_functionacetylcholine receptor inhibitor activity
A0035821biological_processmodulation of process of another organism
A0090729molecular_functiontoxin activity
A0099106molecular_functionion channel regulator activity
Functional Information from PROSITE/UniProt
site_idPS00272
Number of Residues19
DetailsSNAKE_TOXIN Snake toxins signature. GCg..CPtvkpgikls.CCesE
ChainResidueDetails
AGLY40-GLU58

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsSITE: Moderately important residue for binding to acetylcholine receptor => ECO:0000269|PubMed:7721859
ChainResidueDetails
AHIS6
ASER9
ATYR25

site_idSWS_FT_FI2
Number of Residues4
DetailsSITE: Very important residue for binding to acetylcholine receptor => ECO:0000269|PubMed:7721859
ChainResidueDetails
AGLN7
AILE36
AGLU38
ALYS47

site_idSWS_FT_FI3
Number of Residues3
DetailsSITE: Key residue for binding to acetylcholine receptor => ECO:0000269|PubMed:7721859, ECO:0000269|PubMed:8419369
ChainResidueDetails
AGLY8
AGLN10
AARG33

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Key residue for binding to acetylcholine receptor => ECO:0000269|PubMed:8419369
ChainResidueDetails
ALYS27

site_idSWS_FT_FI5
Number of Residues2
DetailsSITE: Very important residue for binding to acetylcholine receptor => ECO:0000269|PubMed:8419369
ChainResidueDetails
ATRP29
AASP31

site_idSWS_FT_FI6
Number of Residues2
DetailsSITE: Moderately important residue for binding to acetylcholine receptor => ECO:0000269|PubMed:8419369
ChainResidueDetails
APHE32
AGLY34

227111

PDB entries from 2024-11-06

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