2ER7

X-RAY ANALYSES OF ASPARTIC PROTEINASES.III. THREE-DIMENSIONAL STRUCTURE OF ENDOTHIAPEPSIN COMPLEXED WITH A TRANSITION-STATE ISOSTERE INHIBITOR OF RENIN AT 1.6 ANGSTROMS RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004190	molecular_function	aspartic-type endopeptidase activity
E	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 900

Chain	Residue
E	TYR175
E	SER178
E	ILE179
E	HOH1172
I	HOH14
I	HOH15

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 E 910

Chain	Residue
E	THR319
E	HOH960
E	HOH999
E	HOH1068
E	HOH1114
E	HOH1115
E	SER108
E	SER109
E	THR318

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 920

Chain	Residue
E	SER132
E	HOH1064

---

site_id	AC4
Number of Residues	25
Details	BINDING SITE FOR CHAIN I OF TRANSITION-STATE ISOSTERE INHIBITOR OF RENIN

Chain	Residue
E	LEU10
E	ASP12
E	ASP30
E	ASP32
E	GLY34
E	SER74
E	TYR75
E	GLY76
E	ASP77
E	ASP114
E	ILE117
E	LEU128
E	ILE213
E	ASP215
E	GLY217
E	THR218
E	THR219
E	PRO277
E	ILE297
E	ILE301
E	HOH921
I	HOH9
I	HOH10
I	HOH11
I	HOH12

---

Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LDFDTGSSDLWV

Chain	Residue	Details
E	LEU29-VAL40
E	GLY212-LEU223

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	311
Details	Domain: {"description":"Peptidase A1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01103","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP32

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	SER35
E	THR218
E	ASP32

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	THR216
E	ASP32
E	THR33

---

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	SER35
E	ASP32

---

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	THR218
E	ASP32
E	THR33

---