2EPH
Crystal structure of fructose-bisphosphate aldolase from Plasmodium falciparum in complex with TRAP-tail determined at 2.7 angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003779 | molecular_function | actin binding |
| A | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016829 | molecular_function | lyase activity |
| A | 0020002 | cellular_component | host cell plasma membrane |
| A | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| B | 0003779 | molecular_function | actin binding |
| B | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016829 | molecular_function | lyase activity |
| B | 0020002 | cellular_component | host cell plasma membrane |
| B | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| C | 0003779 | molecular_function | actin binding |
| C | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006096 | biological_process | glycolytic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016829 | molecular_function | lyase activity |
| C | 0020002 | cellular_component | host cell plasma membrane |
| C | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| D | 0003779 | molecular_function | actin binding |
| D | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006096 | biological_process | glycolytic process |
| D | 0016020 | cellular_component | membrane |
| D | 0016829 | molecular_function | lyase activity |
| D | 0020002 | cellular_component | host cell plasma membrane |
| D | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00158 |
| Number of Residues | 11 |
| Details | ALDOLASE_CLASS_I Fructose-bisphosphate aldolase class-I active site. VlLEGaLLKPN |
| Chain | Residue | Details |
| A | VAL228-ASN238 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:Q8I8I2 |
| Chain | Residue | Details |
| A | GLU194 | |
| B | GLU194 | |
| C | GLU194 | |
| D | GLU194 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Schiff-base intermediate with dihydroxyacetone phosphate => ECO:0000250|UniProtKB:Q8I8I2 |
| Chain | Residue | Details |
| A | LYS236 | |
| B | LYS236 | |
| C | LYS236 | |
| D | LYS236 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8I8I2 |
| Chain | Residue | Details |
| A | ASP39 | |
| A | GLY308 | |
| A | ARG309 | |
| B | ASP39 | |
| B | SER41 | |
| B | THR44 | |
| B | LYS112 | |
| B | LYS151 | |
| B | GLU194 | |
| B | LYS236 | |
| B | SER278 | |
| A | SER41 | |
| B | GLY279 | |
| B | GLY308 | |
| B | ARG309 | |
| C | ASP39 | |
| C | SER41 | |
| C | THR44 | |
| C | LYS112 | |
| C | LYS151 | |
| C | GLU194 | |
| C | LYS236 | |
| A | THR44 | |
| C | SER278 | |
| C | GLY279 | |
| C | GLY308 | |
| C | ARG309 | |
| D | ASP39 | |
| D | SER41 | |
| D | THR44 | |
| D | LYS112 | |
| D | LYS151 | |
| D | GLU194 | |
| A | LYS112 | |
| D | LYS236 | |
| D | SER278 | |
| D | GLY279 | |
| D | GLY308 | |
| D | ARG309 | |
| A | LYS151 | |
| A | GLU194 | |
| A | LYS236 | |
| A | SER278 | |
| A | GLY279 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00883 |
| Chain | Residue | Details |
| A | ARG48 | |
| A | SER306 | |
| B | ARG48 | |
| B | SER306 | |
| C | ARG48 | |
| C | SER306 | |
| D | ARG48 | |
| D | SER306 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | SITE: Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate => ECO:0000250|UniProtKB:P00883 |
| Chain | Residue | Details |
| A | TYR368 | |
| B | TYR368 | |
| C | TYR368 | |
| D | TYR368 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ald |
| Chain | Residue | Details |
| A | LYS236 | |
| A | ASP39 | |
| A | GLU194 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ald |
| Chain | Residue | Details |
| B | LYS236 | |
| B | ASP39 | |
| B | GLU194 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ald |
| Chain | Residue | Details |
| C | LYS236 | |
| C | ASP39 | |
| C | GLU194 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ald |
| Chain | Residue | Details |
| D | LYS236 | |
| D | ASP39 | |
| D | GLU194 |
