2EJ4

Functional and structural basis of nuclear localization signal in ZIC3 zinc finger domain: a role of conserved tryptophan residue in the zinc finger domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
A	0005634	cellular_component	nucleus
A	0006357	biological_process	regulation of transcription by RNA polymerase II

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 201

Chain	Residue
A	CYS16
A	CYS31
A	HIS44
A	HIS49

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	CYS60
A	CYS65
A	HIS81
A	HIS85

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	35
Details	Zinc finger: {"description":"C2H2-type 1; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	27
Details	Zinc finger: {"description":"C2H2-type 2; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	25
Details	Motif: {"description":"Nuclear localization signal"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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