Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2EJ3

Crystal Structure of T.th.HB8 Branched-Chain Amino Acid Aminotransferase Complexed with Gabapentin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004084	molecular_function	branched-chain-amino-acid transaminase activity
A	0005829	cellular_component	cytosol
A	0006532	biological_process	aspartate biosynthetic process
A	0008483	molecular_function	transaminase activity
A	0008652	biological_process	amino acid biosynthetic process
A	0009081	biological_process	branched-chain amino acid metabolic process
A	0009082	biological_process	branched-chain amino acid biosynthetic process
A	0009097	biological_process	isoleucine biosynthetic process
A	0009098	biological_process	L-leucine biosynthetic process
A	0009099	biological_process	valine biosynthetic process
A	0046394	biological_process	carboxylic acid biosynthetic process
A	0050048	molecular_function	L-leucine:2-oxoglutarate aminotransferase activity
A	0052654	molecular_function	L-leucine transaminase activity
A	0052655	molecular_function	L-valine transaminase activity
A	0052656	molecular_function	L-isoleucine transaminase activity
B	0003824	molecular_function	catalytic activity
B	0004084	molecular_function	branched-chain-amino-acid transaminase activity
B	0005829	cellular_component	cytosol
B	0006532	biological_process	aspartate biosynthetic process
B	0008483	molecular_function	transaminase activity
B	0008652	biological_process	amino acid biosynthetic process
B	0009081	biological_process	branched-chain amino acid metabolic process
B	0009082	biological_process	branched-chain amino acid biosynthetic process
B	0009097	biological_process	isoleucine biosynthetic process
B	0009098	biological_process	L-leucine biosynthetic process
B	0009099	biological_process	valine biosynthetic process
B	0046394	biological_process	carboxylic acid biosynthetic process
B	0050048	molecular_function	L-leucine:2-oxoglutarate aminotransferase activity
B	0052654	molecular_function	L-leucine transaminase activity
B	0052655	molecular_function	L-valine transaminase activity
B	0052656	molecular_function	L-isoleucine transaminase activity
C	0003824	molecular_function	catalytic activity
C	0004084	molecular_function	branched-chain-amino-acid transaminase activity
C	0005829	cellular_component	cytosol
C	0006532	biological_process	aspartate biosynthetic process
C	0008483	molecular_function	transaminase activity
C	0008652	biological_process	amino acid biosynthetic process
C	0009081	biological_process	branched-chain amino acid metabolic process
C	0009082	biological_process	branched-chain amino acid biosynthetic process
C	0009097	biological_process	isoleucine biosynthetic process
C	0009098	biological_process	L-leucine biosynthetic process
C	0009099	biological_process	valine biosynthetic process
C	0046394	biological_process	carboxylic acid biosynthetic process
C	0050048	molecular_function	L-leucine:2-oxoglutarate aminotransferase activity
C	0052654	molecular_function	L-leucine transaminase activity
C	0052655	molecular_function	L-valine transaminase activity
C	0052656	molecular_function	L-isoleucine transaminase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PLP A 413

Chain	Residue
A	ARG59
A	THR220
A	GLY255
A	THR256
A	HOH2443
A	HOH2446
A	ARG148
A	LYS159
A	TYR164
A	GLU193
A	GLY196
A	LEU216
A	GLY218
A	ILE219

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP B 913

Chain	Residue
B	ARG59
B	LYS159
B	TYR164
B	GLU193
B	GLY196
B	LEU216
B	GLY218
B	ILE219
B	THR220
B	GLY255
B	THR256
B	HOH928
B	HOH958

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PLP C 1413

Chain	Residue
C	ARG59
C	ARG148
C	LYS159
C	TYR164
C	GLU193
C	GLY196
C	LEU216
C	GLY218
C	ILE219
C	THR220
C	GLY255
C	THR256
C	HOH1425
C	HOH1447

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GBN A 2414

Chain	Residue
A	ARG97
A	GLY196
A	GLU197
A	GLY255
A	THR256
A	ALA257
A	ALA258
A	HOH2539
A	HOH2554
C	TYR31

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GBN B 914

Chain	Residue
B	ARG97
B	GLY196
B	GLU197
B	GLY255
B	THR256
B	ALA257
B	ALA258
B	HOH983
B	HOH984
B	HOH1091

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GBN C 1414

Chain	Residue
A	TYR31
C	ARG97
C	GLY196
C	GLU197
C	GLY255
C	THR256
C	ALA257
C	ALA258
C	HOH1457
C	HOH1469
C	HOH1572

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD A 2416

Chain	Residue
A	ASP230
A	GLU297
A	HOH2472
A	HOH2502
C	GLU289
C	ARG294
C	ARG295

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MPD A 1417

Chain	Residue
A	ARG52
A	GLU55
A	GLU217
A	ILE219
A	ASP222
A	HOH2524
A	HOH2532
C	ARG203
C	ASP204

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MPD B 915

Chain	Residue
B	LEU107
B	TRP124
B	TRP126

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MPD B 917

Chain	Residue
A	ARG203
A	ASP204
B	ARG52
B	GLU55
B	GLU217
B	GLY218
B	ASP222
B	HOH967

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MPD C 1416

Chain	Residue
B	ARG203
B	ASP204
C	ARG52
C	GLU55
C	GLU217
C	ASP222
C	HOH1521
C	HOH1569

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1iyd

Chain	Residue	Details
A	LYS159

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1iyd

Chain	Residue	Details
B	LYS159

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1iyd

Chain	Residue	Details
C	LYS159

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)