Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2EJ2

Crystal Structure of T.th.HB8 Branched-Chain Amino Acid Aminotransferase Complexed with N-(5'-Phosphopyridoxyl)-L-Glutamate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004084	molecular_function	branched-chain-amino-acid transaminase activity
A	0008483	molecular_function	transaminase activity
A	0008652	biological_process	amino acid biosynthetic process
A	0009081	biological_process	branched-chain amino acid metabolic process
A	0009082	biological_process	branched-chain amino acid biosynthetic process
A	0009097	biological_process	isoleucine biosynthetic process
A	0009098	biological_process	L-leucine biosynthetic process
A	0009099	biological_process	valine biosynthetic process
A	0019752	biological_process	carboxylic acid metabolic process
A	0046394	biological_process	carboxylic acid biosynthetic process
A	0050048	molecular_function	L-leucine:2-oxoglutarate aminotransferase activity
A	0052654	molecular_function	L-leucine transaminase activity
A	0052655	molecular_function	L-valine transaminase activity
A	0052656	molecular_function	L-isoleucine transaminase activity
B	0003824	molecular_function	catalytic activity
B	0004084	molecular_function	branched-chain-amino-acid transaminase activity
B	0008483	molecular_function	transaminase activity
B	0008652	biological_process	amino acid biosynthetic process
B	0009081	biological_process	branched-chain amino acid metabolic process
B	0009082	biological_process	branched-chain amino acid biosynthetic process
B	0009097	biological_process	isoleucine biosynthetic process
B	0009098	biological_process	L-leucine biosynthetic process
B	0009099	biological_process	valine biosynthetic process
B	0019752	biological_process	carboxylic acid metabolic process
B	0046394	biological_process	carboxylic acid biosynthetic process
B	0050048	molecular_function	L-leucine:2-oxoglutarate aminotransferase activity
B	0052654	molecular_function	L-leucine transaminase activity
B	0052655	molecular_function	L-valine transaminase activity
B	0052656	molecular_function	L-isoleucine transaminase activity
C	0003824	molecular_function	catalytic activity
C	0004084	molecular_function	branched-chain-amino-acid transaminase activity
C	0008483	molecular_function	transaminase activity
C	0008652	biological_process	amino acid biosynthetic process
C	0009081	biological_process	branched-chain amino acid metabolic process
C	0009082	biological_process	branched-chain amino acid biosynthetic process
C	0009097	biological_process	isoleucine biosynthetic process
C	0009098	biological_process	L-leucine biosynthetic process
C	0009099	biological_process	valine biosynthetic process
C	0019752	biological_process	carboxylic acid metabolic process
C	0046394	biological_process	carboxylic acid biosynthetic process
C	0050048	molecular_function	L-leucine:2-oxoglutarate aminotransferase activity
C	0052654	molecular_function	L-leucine transaminase activity
C	0052655	molecular_function	L-valine transaminase activity
C	0052656	molecular_function	L-isoleucine transaminase activity
D	0003824	molecular_function	catalytic activity
D	0004084	molecular_function	branched-chain-amino-acid transaminase activity
D	0008483	molecular_function	transaminase activity
D	0008652	biological_process	amino acid biosynthetic process
D	0009081	biological_process	branched-chain amino acid metabolic process
D	0009082	biological_process	branched-chain amino acid biosynthetic process
D	0009097	biological_process	isoleucine biosynthetic process
D	0009098	biological_process	L-leucine biosynthetic process
D	0009099	biological_process	valine biosynthetic process
D	0019752	biological_process	carboxylic acid metabolic process
D	0046394	biological_process	carboxylic acid biosynthetic process
D	0050048	molecular_function	L-leucine:2-oxoglutarate aminotransferase activity
D	0052654	molecular_function	L-leucine transaminase activity
D	0052655	molecular_function	L-valine transaminase activity
D	0052656	molecular_function	L-isoleucine transaminase activity
E	0003824	molecular_function	catalytic activity
E	0004084	molecular_function	branched-chain-amino-acid transaminase activity
E	0008483	molecular_function	transaminase activity
E	0008652	biological_process	amino acid biosynthetic process
E	0009081	biological_process	branched-chain amino acid metabolic process
E	0009082	biological_process	branched-chain amino acid biosynthetic process
E	0009097	biological_process	isoleucine biosynthetic process
E	0009098	biological_process	L-leucine biosynthetic process
E	0009099	biological_process	valine biosynthetic process
E	0019752	biological_process	carboxylic acid metabolic process
E	0046394	biological_process	carboxylic acid biosynthetic process
E	0050048	molecular_function	L-leucine:2-oxoglutarate aminotransferase activity
E	0052654	molecular_function	L-leucine transaminase activity
E	0052655	molecular_function	L-valine transaminase activity
E	0052656	molecular_function	L-isoleucine transaminase activity
F	0003824	molecular_function	catalytic activity
F	0004084	molecular_function	branched-chain-amino-acid transaminase activity
F	0008483	molecular_function	transaminase activity
F	0008652	biological_process	amino acid biosynthetic process
F	0009081	biological_process	branched-chain amino acid metabolic process
F	0009082	biological_process	branched-chain amino acid biosynthetic process
F	0009097	biological_process	isoleucine biosynthetic process
F	0009098	biological_process	L-leucine biosynthetic process
F	0009099	biological_process	valine biosynthetic process
F	0019752	biological_process	carboxylic acid metabolic process
F	0046394	biological_process	carboxylic acid biosynthetic process
F	0050048	molecular_function	L-leucine:2-oxoglutarate aminotransferase activity
F	0052654	molecular_function	L-leucine transaminase activity
F	0052655	molecular_function	L-valine transaminase activity
F	0052656	molecular_function	L-isoleucine transaminase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE PPE A 3413

Chain	Residue
A	GLY38
A	LEU216
A	GLY218
A	ILE219
A	THR220
A	THR256
A	ALA257
A	HOH3431
A	HOH3440
A	HOH3460
E	TYR31
A	ARG59
A	TYR95
A	ARG148
A	LYS159
A	TYR164
A	GLU193
A	SER195
A	GLY196

site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE PPE B 3913

Chain	Residue
B	GLY38
B	ARG59
B	TYR95
B	ARG148
B	LYS159
B	TYR164
B	GLU193
B	SER195
B	GLY196
B	LEU216
B	GLY218
B	ILE219
B	THR220
B	GLY255
B	THR256
B	ALA257
B	HOH3915
B	HOH3918
B	HOH3956
B	HOH4011

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE PPE C 1413

Chain	Residue
C	GLY38
C	ARG59
C	TYR95
C	ARG148
C	LYS159
C	TYR164
C	GLU193
C	GLY196
C	LEU216
C	GLY218
C	ILE219
C	THR220
C	GLY255
C	THR256
C	ALA257
C	HOH1422
C	HOH1424
C	HOH1425

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE PPE D 1913

Chain	Residue
D	GLY38
D	ARG59
D	TYR95
D	ARG148
D	TYR164
D	GLU193
D	SER195
D	GLY196
D	LEU216
D	GLY218
D	ILE219
D	THR220
D	GLY255
D	THR256
D	ALA257
D	HOH1917
D	HOH1918
D	HOH1981
D	HOH2034

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE PPE E 2413

Chain	Residue
E	GLY38
E	ARG59
E	TYR95
E	ARG148
E	LYS159
E	TYR164
E	GLU193
E	GLY196
E	GLU197
E	LEU216
E	GLY218
E	ILE219
E	THR220
E	GLY255
E	THR256
E	ALA257
E	HOH2422
E	HOH2424
E	HOH2478
E	HOH2481

site_id	AC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE PPE F 2913

Chain	Residue
F	TYR95
F	ARG148
F	LYS159
F	TYR164
F	GLU193
F	GLY196
F	GLU197
F	LEU216
F	GLY218
F	ILE219
F	THR220
F	GLY255
F	THR256
F	ALA257
F	HOH2918
F	HOH2919
F	HOH2982
C	TYR31
F	GLY38
F	ARG59

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD A 1415

Chain	Residue
A	ASP230
E	GLU289
E	ARG294
E	ARG295

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD F 2914

Chain	Residue
C	GLU289
C	ARG294
C	ARG295
F	ASP230
F	GLU297
F	HOH2975
F	HOH3039

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1iyd

Chain	Residue	Details
A	LYS159

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1iyd

Chain	Residue	Details
B	LYS159

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1iyd

Chain	Residue	Details
C	LYS159

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1iyd

Chain	Residue	Details
D	LYS159

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1iyd

Chain	Residue	Details
E	LYS159

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1iyd

Chain	Residue	Details
F	LYS159

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)