2EIY
Crystal Structure of T.th.HB8 Branched-Chain Amino Acid Aminotransferase Complexed with 4-Methylvaleric Acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004084 | molecular_function | branched-chain-amino-acid transaminase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009081 | biological_process | branched-chain amino acid metabolic process |
| A | 0009098 | biological_process | L-leucine biosynthetic process |
| A | 0009099 | biological_process | L-valine biosynthetic process |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0046394 | biological_process | carboxylic acid biosynthetic process |
| A | 0052654 | molecular_function | L-leucine-2-oxoglutarate transaminase activity |
| A | 0052655 | molecular_function | L-valine-2-oxoglutarate transaminase activity |
| A | 0052656 | molecular_function | L-isoleucine-2-oxoglutarate transaminase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004084 | molecular_function | branched-chain-amino-acid transaminase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009081 | biological_process | branched-chain amino acid metabolic process |
| B | 0009098 | biological_process | L-leucine biosynthetic process |
| B | 0009099 | biological_process | L-valine biosynthetic process |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0046394 | biological_process | carboxylic acid biosynthetic process |
| B | 0052654 | molecular_function | L-leucine-2-oxoglutarate transaminase activity |
| B | 0052655 | molecular_function | L-valine-2-oxoglutarate transaminase activity |
| B | 0052656 | molecular_function | L-isoleucine-2-oxoglutarate transaminase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004084 | molecular_function | branched-chain-amino-acid transaminase activity |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009081 | biological_process | branched-chain amino acid metabolic process |
| C | 0009098 | biological_process | L-leucine biosynthetic process |
| C | 0009099 | biological_process | L-valine biosynthetic process |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0046394 | biological_process | carboxylic acid biosynthetic process |
| C | 0052654 | molecular_function | L-leucine-2-oxoglutarate transaminase activity |
| C | 0052655 | molecular_function | L-valine-2-oxoglutarate transaminase activity |
| C | 0052656 | molecular_function | L-isoleucine-2-oxoglutarate transaminase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP A 413 |
| Chain | Residue |
| A | ARG59 |
| A | ILE219 |
| A | THR220 |
| A | GLY255 |
| A | THR256 |
| A | HOH2420 |
| A | HOH2443 |
| A | ARG148 |
| A | LYS159 |
| A | TYR164 |
| A | GLU193 |
| A | GLY196 |
| A | GLU197 |
| A | LEU216 |
| A | GLY218 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PLP B 913 |
| Chain | Residue |
| B | ARG59 |
| B | LYS159 |
| B | TYR164 |
| B | GLU193 |
| B | GLY196 |
| B | GLU197 |
| B | LEU216 |
| B | GLY218 |
| B | ILE219 |
| B | THR220 |
| B | GLY255 |
| B | THR256 |
| B | HOH926 |
| B | HOH944 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PLP C 1413 |
| Chain | Residue |
| C | ARG59 |
| C | ARG148 |
| C | LYS159 |
| C | TYR164 |
| C | GLU193 |
| C | GLY196 |
| C | LEU216 |
| C | GLY218 |
| C | ILE219 |
| C | THR220 |
| C | GLY255 |
| C | THR256 |
| C | HOH1423 |
| C | HOH1466 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 4MV A 2414 |
| Chain | Residue |
| A | TYR95 |
| A | GLY196 |
| A | THR256 |
| A | ALA257 |
| A | HOH2456 |
| C | TYR31 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 4MV B 914 |
| Chain | Residue |
| B | TYR31 |
| B | GLY38 |
| B | TYR95 |
| B | GLY196 |
| B | THR256 |
| B | ALA257 |
| B | HOH962 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 4MV C 1414 |
| Chain | Residue |
| C | GLY38 |
| C | TYR95 |
| C | THR256 |
| C | ALA257 |
| C | HOH1464 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD A 2416 |
| Chain | Residue |
| A | ASP230 |
| A | GLU297 |
| A | HOH2483 |
| C | GLU289 |
| C | ARG294 |
| C | ARG295 |
| C | HOH1639 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MPD A 2417 |
| Chain | Residue |
| A | ARG52 |
| A | GLU55 |
| A | GLU217 |
| A | ILE219 |
| A | ASP222 |
| A | HOH2473 |
| C | ARG203 |
| C | ASP204 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD B 915 |
| Chain | Residue |
| B | TYR95 |
| B | LEU107 |
| B | TRP124 |
| B | TRP126 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MPD B 917 |
| Chain | Residue |
| A | ARG203 |
| A | ASP204 |
| B | ARG52 |
| B | GLU55 |
| B | GLU217 |
| B | GLY218 |
| B | ASP222 |
| B | HOH975 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MPD C 1416 |
| Chain | Residue |
| B | ARG203 |
| B | ASP204 |
| C | ARG52 |
| C | GLU55 |
| C | GLU217 |
| C | ILE219 |
| C | ASP222 |
| C | HOH1481 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1iyd |
| Chain | Residue | Details |
| A | LYS159 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1iyd |
| Chain | Residue | Details |
| B | LYS159 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1iyd |
| Chain | Residue | Details |
| C | LYS159 |
