Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2EHJ

Structure of Uracil phosphoribosyl transferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004845	molecular_function	uracil phosphoribosyltransferase activity
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006223	biological_process	uracil salvage
A	0008655	biological_process	pyrimidine-containing compound salvage
A	0016020	cellular_component	membrane
A	0016757	molecular_function	glycosyltransferase activity
A	0042802	molecular_function	identical protein binding
A	0044206	biological_process	UMP salvage
A	0097216	molecular_function	guanosine tetraphosphate binding
B	0000287	molecular_function	magnesium ion binding
B	0004845	molecular_function	uracil phosphoribosyltransferase activity
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006223	biological_process	uracil salvage
B	0008655	biological_process	pyrimidine-containing compound salvage
B	0016020	cellular_component	membrane
B	0016757	molecular_function	glycosyltransferase activity
B	0042802	molecular_function	identical protein binding
B	0044206	biological_process	UMP salvage
B	0097216	molecular_function	guanosine tetraphosphate binding
C	0000287	molecular_function	magnesium ion binding
C	0004845	molecular_function	uracil phosphoribosyltransferase activity
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006223	biological_process	uracil salvage
C	0008655	biological_process	pyrimidine-containing compound salvage
C	0016020	cellular_component	membrane
C	0016757	molecular_function	glycosyltransferase activity
C	0042802	molecular_function	identical protein binding
C	0044206	biological_process	UMP salvage
C	0097216	molecular_function	guanosine tetraphosphate binding
D	0000287	molecular_function	magnesium ion binding
D	0004845	molecular_function	uracil phosphoribosyltransferase activity
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006223	biological_process	uracil salvage
D	0008655	biological_process	pyrimidine-containing compound salvage
D	0016020	cellular_component	membrane
D	0016757	molecular_function	glycosyltransferase activity
D	0042802	molecular_function	identical protein binding
D	0044206	biological_process	UMP salvage
D	0097216	molecular_function	guanosine tetraphosphate binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 209

Chain	Residue
A	LYS1
A	LYS2
A	LEU169
A	GLU170
A	HIS173
A	PRO174

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 209

Chain	Residue
B	GLU170
B	HIS173
B	PRO174
B	LYS1
B	LYS2
B	LEU169

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 209

Chain	Residue
C	LYS1
C	LYS2
C	ILE166
C	LEU169
C	GLU170
C	HIS173
C	PRO174

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 209

Chain	Residue
D	LYS1
D	LYS2
D	LEU169
D	GLU170
D	HIS173
D	PRO174

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 210

Chain	Residue
A	ARG103
A	ALA134
A	THR135
A	GLY136
A	GLY137
A	SER138

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 210

Chain	Residue
B	ARG103
B	ALA134
B	THR135
B	GLY136
B	GLY137
B	SER138

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 210

Chain	Residue
C	ALA134
C	THR135
C	GLY136
C	GLY137
C	SER138

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 210

Chain	Residue
D	ARG103
D	ALA134
D	THR135
D	GLY136
D	GLY137
D	SER138

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 211

Chain	Residue
A	LYS69
A	LYS70
A	ARG95
A	ARG124

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 211

Chain	Residue
C	LYS69
C	LYS70
C	ARG95
C	ARG124

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 211

Chain	Residue
D	LYS69
D	LYS70
D	ARG95
D	ARG124
D	HOH226

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 212

Chain	Residue
A	ARG78
A	ALA79

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 211

Chain	Residue
B	ARG78
B	ALA79

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 212

Chain	Residue
C	LEU77
C	ARG78
C	ALA79
C	ARG103
C	GLY201

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 212

Chain	Residue
D	LEU77
D	ARG78
D	ALA79

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 213

Chain	Residue
C	SER24
C	THR25
D	LYS70
D	ARG95
D	HOH220

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 213

Chain	Residue
C	ARG95
D	SER24
D	THR25

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 213

Chain	Residue
A	ARG95
B	SER24
B	THR25

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 212

Chain	Residue
A	SER24
A	THR25
B	LYS70
B	ARG95

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ARG78
A	ARG103
C	ARG78
C	ARG103
C	ASP130
C	ILE193
C	GLY198
C	ASP199
D	ARG78
D	ARG103
D	ASP130
D	ILE193
D	GLY198
D	ASP199
A	ASP130
A	ILE193
A	GLY198
A	ASP199
B	ARG78
B	ARG103
B	ASP130
B	ILE193
B	GLY198
B	ASP199

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)