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2EGD

Crystal structure of human S100A13 in the Ca2+-bound state

Functional Information from GO Data
ChainGOidnamespacecontents
A0001819biological_processpositive regulation of cytokine production
A0005507molecular_functioncopper ion binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0008270molecular_functionzinc ion binding
A0008284biological_processpositive regulation of cell population proliferation
A0008289molecular_functionlipid binding
A0015031biological_processprotein transport
A0017134molecular_functionfibroblast growth factor binding
A0032730biological_processpositive regulation of interleukin-1 alpha production
A0042803molecular_functionprotein homodimerization activity
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043303biological_processmast cell degranulation
A0046872molecular_functionmetal ion binding
A0048306molecular_functioncalcium-dependent protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050786molecular_functionRAGE receptor binding
B0001819biological_processpositive regulation of cytokine production
B0005507molecular_functioncopper ion binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0008270molecular_functionzinc ion binding
B0008284biological_processpositive regulation of cell population proliferation
B0008289molecular_functionlipid binding
B0015031biological_processprotein transport
B0017134molecular_functionfibroblast growth factor binding
B0032730biological_processpositive regulation of interleukin-1 alpha production
B0042803molecular_functionprotein homodimerization activity
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043303biological_processmast cell degranulation
B0046872molecular_functionmetal ion binding
B0048306molecular_functioncalcium-dependent protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050786molecular_functionRAGE receptor binding
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 301
ChainResidue
AALA24
AGLU27
AARG29
ASER32
AGLU37
AHOH313

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 302
ChainResidue
AGLU70
AGLU75
AHOH319
AASP64
AASN66
AASP68

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 303
ChainResidue
BALA24
BGLU27
BARG29
BSER32
BGLU37
BHOH311

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 304
ChainResidue
BASP64
BASN66
BASP68
BGLU70
BGLU75
BHOH320

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
ASER32
BASP64
BASN66
BASP68
BGLU70
BGLU75
AGLU37
AASP64
AASN66
AASP68
AGLU70
AGLU75
BSER32
BGLU37

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P97352
ChainResidueDetails
ASER32
BSER32

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PDB entries from 2024-04-24

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