2EG5

The structure of xanthosine methyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008168	molecular_function	methyltransferase activity
A	0009820	biological_process	alkaloid metabolic process
A	0016740	molecular_function	transferase activity
A	0032259	biological_process	methylation
A	0046872	molecular_function	metal ion binding
C	0008168	molecular_function	methyltransferase activity
C	0009820	biological_process	alkaloid metabolic process
C	0016740	molecular_function	transferase activity
C	0032259	biological_process	methylation
C	0046872	molecular_function	metal ion binding
E	0008168	molecular_function	methyltransferase activity
E	0009820	biological_process	alkaloid metabolic process
E	0016740	molecular_function	transferase activity
E	0032259	biological_process	methylation
E	0046872	molecular_function	metal ion binding
G	0008168	molecular_function	methyltransferase activity
G	0009820	biological_process	alkaloid metabolic process
G	0016740	molecular_function	transferase activity
G	0032259	biological_process	methylation
G	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAH A 501

Chain	Residue
A	TYR18
A	TYR142
A	CYS157
A	TYR158
A	CYS159
A	HOH522
A	HOH524
A	HOH577
A	HOH644
A	GLY61
A	ALA63
A	ASN100
A	ASP101
A	LEU102
A	GLY139
A	SER140
A	PHE141

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE XTS A 502

Chain	Residue
A	ASN21
A	SER22
A	TYR24
A	ASN25
A	TYR158
A	GLN161
A	TRP162
A	SER316
A	TYR321
A	TYR356

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SAH C 1501

Chain	Residue
C	TYR18
C	GLY61
C	ALA63
C	ASN100
C	ASP101
C	LEU102
C	GLY139
C	SER140
C	PHE141
C	CYS157
C	TYR158
C	CYS159
C	HOH1503
C	HOH1508
C	HOH1558

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE XTS C 1502

Chain	Residue
C	ASN21
C	SER22
C	TYR24
C	ASN25
C	TYR158
C	GLN161
C	TRP162
C	SER316
C	TYR321
C	TYR356

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE SAH E 2501

Chain	Residue
E	TYR18
E	LEU29
E	GLY61
E	ALA63
E	ASN100
E	ASP101
E	GLY139
E	SER140
E	PHE141
E	TYR142
E	CYS157
E	TYR158
E	CYS159
E	TRP162
E	HOH2540
E	HOH2562

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE XTS E 2502

Chain	Residue
E	ASN21
E	SER22
E	TYR24
E	ASN25
E	TYR158
E	GLN161
E	TRP162
E	SER316
E	TYR321
E	TYR356
E	HOH2550
E	HOH2564
E	HOH2598

---

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE SAH G 3501

Chain	Residue
G	TYR18
G	GLY61
G	ALA63
G	ASN100
G	ASP101
G	LEU102
G	GLY139
G	SER140
G	PHE141
G	TYR142
G	CYS157
G	TYR158
G	CYS159
G	HOH3505
G	HOH3511
G	HOH3573

---

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE XTS G 3502

Chain	Residue
G	TYR24
G	ASN25
G	TYR158
G	GLN161
G	TRP162
G	SER316
G	VAL320
G	TYR321
G	TYR356
G	ASN21
G	SER22

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17434991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2EG5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"A4GE70","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9FLN8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Site: {"description":"Involved in substrate discrimination","evidences":[{"source":"UniProtKB","id":"Q9FZN8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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