2EF5
Crystal structure of the arginase from thermus thermophilus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004053 | molecular_function | arginase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006525 | biological_process | arginine metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004053 | molecular_function | arginase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006525 | biological_process | arginine metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| D | 0004053 | molecular_function | arginase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006525 | biological_process | arginine metabolic process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004053 | molecular_function | arginase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006525 | biological_process | arginine metabolic process |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| E | 0030145 | molecular_function | manganese ion binding |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004053 | molecular_function | arginase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006525 | biological_process | arginine metabolic process |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| F | 0030145 | molecular_function | manganese ion binding |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0004053 | molecular_function | arginase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006525 | biological_process | arginine metabolic process |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| G | 0030145 | molecular_function | manganese ion binding |
| G | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 1101 |
| Chain | Residue |
| A | ASP119 |
| A | HIS121 |
| A | ASP218 |
| A | ASP220 |
| A | MN1102 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 1102 |
| Chain | Residue |
| A | MN1101 |
| A | HIS97 |
| A | ASP119 |
| A | ASP123 |
| A | ASP218 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 1601 |
| Chain | Residue |
| B | ASP119 |
| B | HIS121 |
| B | ASP218 |
| B | ASP220 |
| B | MN1602 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 1602 |
| Chain | Residue |
| B | HIS97 |
| B | ASP119 |
| B | ASP123 |
| B | ASP218 |
| B | MN1601 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN D 1201 |
| Chain | Residue |
| D | ASP119 |
| D | HIS121 |
| D | ASP218 |
| D | ASP220 |
| D | MN1202 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN D 1202 |
| Chain | Residue |
| D | HIS97 |
| D | ASP119 |
| D | ASP123 |
| D | ASP218 |
| D | MN1201 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN E 1301 |
| Chain | Residue |
| E | ASP119 |
| E | HIS121 |
| E | ASP218 |
| E | ASP220 |
| E | MN1302 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN E 1302 |
| Chain | Residue |
| E | HIS97 |
| E | ASP119 |
| E | ASP123 |
| E | ASP218 |
| E | MN1301 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN F 1401 |
| Chain | Residue |
| F | ASP119 |
| F | HIS121 |
| F | ASP218 |
| F | ASP220 |
| F | MN1402 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN F 1402 |
| Chain | Residue |
| F | HIS97 |
| F | ASP119 |
| F | ASP123 |
| F | ASP218 |
| F | MN1401 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN G 1501 |
| Chain | Residue |
| G | ASP119 |
| G | HIS121 |
| G | ASP218 |
| G | ASP220 |
| G | MN1502 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN G 1502 |
| Chain | Residue |
| G | HIS97 |
| G | ASP119 |
| G | ASP123 |
| G | ASP218 |
| G | MN1501 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GAI A 1001 |
| Chain | Residue |
| A | GLU248 |
| D | HIS190 |
| D | ASP193 |
| D | HOH3015 |
| D | HOH3058 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GAI A 1004 |
| Chain | Residue |
| A | ASP193 |
| A | HOH3051 |
| F | GLU248 |
| site_id | BC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE LYS A 3001 |
| Chain | Residue |
| A | PRO10 |
| A | ASP21 |
| A | MET22 |
| A | SER25 |
| A | HOH3009 |
| A | HOH3076 |
| E | ASP21 |
| E | MET22 |
| E | LYS3003 |
| E | HOH3121 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GAI B 1006 |
| Chain | Residue |
| B | GLU248 |
| E | ASP193 |
| E | HOH3007 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LYS B 3006 |
| Chain | Residue |
| B | ASP21 |
| B | SER25 |
| B | HOH3013 |
| D | ASP21 |
| D | LYS3002 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GAI D 1002 |
| Chain | Residue |
| D | GLU248 |
| F | ASP193 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE LYS D 3002 |
| Chain | Residue |
| B | ASP21 |
| B | MET22 |
| B | LYS3006 |
| D | PRO10 |
| D | ASP21 |
| D | SER25 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GAI E 1003 |
| Chain | Residue |
| E | GLU248 |
| E | HOH3005 |
| G | MET189 |
| G | HIS190 |
| G | ASP193 |
| site_id | CC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE LYS E 3003 |
| Chain | Residue |
| A | ASP21 |
| A | LYS3001 |
| A | HOH3076 |
| E | PRO10 |
| E | ASP21 |
| E | MET22 |
| E | SER25 |
| E | HOH3058 |
| E | HOH3084 |
| E | HOH3121 |
| site_id | CC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE LYS F 3004 |
| Chain | Residue |
| F | PRO10 |
| F | ASP21 |
| F | MET22 |
| F | SER25 |
| F | HOH3097 |
| G | ASP21 |
| G | MET22 |
| G | LYS3005 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GAI G 1005 |
| Chain | Residue |
| B | HIS190 |
| B | ASP193 |
| G | GLU248 |
| site_id | CC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE LYS G 3005 |
| Chain | Residue |
| F | LYS3004 |
| F | HOH3097 |
| G | PRO10 |
| G | ASP21 |
| G | MET22 |
| G | SER25 |
| G | HOH3038 |
| G | HOH3062 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1cev |
| Chain | Residue | Details |
| A | ASP123 | |
| A | GLU263 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1cev |
| Chain | Residue | Details |
| B | ASP123 | |
| B | GLU263 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1cev |
| Chain | Residue | Details |
| D | ASP123 | |
| D | GLU263 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1cev |
| Chain | Residue | Details |
| E | ASP123 | |
| E | GLU263 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1cev |
| Chain | Residue | Details |
| F | ASP123 | |
| F | GLU263 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1cev |
| Chain | Residue | Details |
| G | ASP123 | |
| G | GLU263 |
