2ED5
Mutant S147M structure of PH0725 from Pyrococcus horikoshii OT3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004164 | molecular_function | diphthine synthase activity |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0017183 | biological_process | protein histidyl modification to diphthamide |
| A | 0032259 | biological_process | methylation |
| B | 0004164 | molecular_function | diphthine synthase activity |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0017183 | biological_process | protein histidyl modification to diphthamide |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1302 |
| Chain | Residue |
| A | TYR117 |
| A | HOH1422 |
| B | HOH1305 |
| B | HOH1308 |
| B | HOH1312 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SAH A 1301 |
| Chain | Residue |
| A | VAL90 |
| A | SER115 |
| A | ILE116 |
| A | PHE165 |
| A | LEU166 |
| A | LEU206 |
| A | ARG208 |
| A | ALA209 |
| A | PRO233 |
| A | HIS234 |
| A | ILE235 |
| A | HOH1313 |
| A | HOH1385 |
| A | HOH1400 |
| A | LEU10 |
| A | THR36 |
| A | SER37 |
| A | ASP87 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1303 |
| Chain | Residue |
| B | PHE34 |
| B | LEU38 |
| B | MET39 |
| B | LEU44 |
| B | ARG173 |
| B | HOH1458 |
| B | HOH1498 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 1304 |
| Chain | Residue |
| B | LYS222 |
| B | GLU259 |
| B | VAL263 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01084","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18391406","evidenceCode":"ECO:0000305"},{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of diphthine synthase from Pyrococcus horikoshii OT3.","authoringGroup":["RIKEN structural genomics initiative (RSGI)"]}}]} |
| Chain | Residue | Details |
