2ECS
Lambda Cro mutant Q27P/A29S/K32Q at 1.4 A in space group C2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001046 | molecular_function | core promoter sequence-specific DNA binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0009411 | biological_process | response to UV |
| A | 0010944 | biological_process | negative regulation of transcription by competitive promoter binding |
| A | 0019042 | biological_process | viral latency |
| A | 0019046 | biological_process | release from viral latency |
| A | 0032897 | biological_process | negative regulation of viral transcription |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0098689 | biological_process | latency-replication decision |
| B | 0001046 | molecular_function | core promoter sequence-specific DNA binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0009411 | biological_process | response to UV |
| B | 0010944 | biological_process | negative regulation of transcription by competitive promoter binding |
| B | 0019042 | biological_process | viral latency |
| B | 0019046 | biological_process | release from viral latency |
| B | 0032897 | biological_process | negative regulation of viral transcription |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0098689 | biological_process | latency-replication decision |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 204 |
| Chain | Residue |
| A | ARG13 |
| A | THR17 |
| A | HOH216 |
| A | HOH263 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT A 205 |
| Chain | Residue |
| B | ARG13 |
| B | HOH229 |
| A | MET12 |
| A | ARG13 |
| A | GLN16 |
| A | ASN31 |
| A | HOH228 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 208 |
| Chain | Residue |
| A | HIS35 |
| A | HOH253 |
| B | ARG13 |
| B | HOH255 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 201 |
| Chain | Residue |
| A | GLN3 |
| A | ARG13 |
| A | PHE14 |
| B | ASP9 |
| B | ACT206 |
| B | LI210 |
| B | HOH241 |
| B | HOH256 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 202 |
| Chain | Residue |
| B | GLY15 |
| B | GLN16 |
| B | THR17 |
| B | HOH233 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 203 |
| Chain | Residue |
| A | ARG38 |
| A | HOH217 |
| B | PHE58 |
| B | PRO59 |
| B | SER60 |
| B | HOH266 |
| B | HOH291 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT B 206 |
| Chain | Residue |
| A | GLN3 |
| A | ARG13 |
| B | ILE5 |
| B | ASP9 |
| B | SO4201 |
| B | LI210 |
| B | HOH214 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT B 207 |
| Chain | Residue |
| A | ASP9 |
| A | HOH250 |
| B | ILE5 |
| B | ARG13 |
| B | LI211 |
| B | HOH255 |
| B | HOH288 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 209 |
| Chain | Residue |
| B | SER28 |
| B | GLN32 |
| B | HIS35 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE LI B 210 |
| Chain | Residue |
| A | GLN3 |
| B | ILE5 |
| B | THR6 |
| B | ASP9 |
| B | SO4201 |
| B | ACT206 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LI B 211 |
| Chain | Residue |
| A | ILE5 |
| A | THR6 |
| A | ASP9 |
| B | GLN3 |
| B | ACT207 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 38 |
| Details | DNA_BIND: H-T-H motif |
| Chain | Residue | Details |
| A | GLN16-HIS35 | |
| B | GLN16-HIS35 |
