Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2EBA

Crystal structure of the putative glutaryl-CoA dehydrogenase from thermus thermophilus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000062	molecular_function	fatty-acyl-CoA binding
A	0000166	molecular_function	nucleotide binding
A	0003995	molecular_function	acyl-CoA dehydrogenase activity
A	0004361	molecular_function	glutaryl-CoA dehydrogenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
A	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A	0046949	biological_process	fatty-acyl-CoA biosynthetic process
A	0050660	molecular_function	flavin adenine dinucleotide binding
C	0000062	molecular_function	fatty-acyl-CoA binding
C	0000166	molecular_function	nucleotide binding
C	0003995	molecular_function	acyl-CoA dehydrogenase activity
C	0004361	molecular_function	glutaryl-CoA dehydrogenase activity
C	0016491	molecular_function	oxidoreductase activity
C	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
C	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C	0046949	biological_process	fatty-acyl-CoA biosynthetic process
C	0050660	molecular_function	flavin adenine dinucleotide binding
D	0000062	molecular_function	fatty-acyl-CoA binding
D	0000166	molecular_function	nucleotide binding
D	0003995	molecular_function	acyl-CoA dehydrogenase activity
D	0004361	molecular_function	glutaryl-CoA dehydrogenase activity
D	0016491	molecular_function	oxidoreductase activity
D	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
D	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D	0046949	biological_process	fatty-acyl-CoA biosynthetic process
D	0050660	molecular_function	flavin adenine dinucleotide binding
E	0000062	molecular_function	fatty-acyl-CoA binding
E	0000166	molecular_function	nucleotide binding
E	0003995	molecular_function	acyl-CoA dehydrogenase activity
E	0004361	molecular_function	glutaryl-CoA dehydrogenase activity
E	0016491	molecular_function	oxidoreductase activity
E	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
E	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E	0046949	biological_process	fatty-acyl-CoA biosynthetic process
E	0050660	molecular_function	flavin adenine dinucleotide binding
F	0000062	molecular_function	fatty-acyl-CoA binding
F	0000166	molecular_function	nucleotide binding
F	0003995	molecular_function	acyl-CoA dehydrogenase activity
F	0004361	molecular_function	glutaryl-CoA dehydrogenase activity
F	0016491	molecular_function	oxidoreductase activity
F	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
F	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F	0046949	biological_process	fatty-acyl-CoA biosynthetic process
F	0050660	molecular_function	flavin adenine dinucleotide binding
G	0000062	molecular_function	fatty-acyl-CoA binding
G	0000166	molecular_function	nucleotide binding
G	0003995	molecular_function	acyl-CoA dehydrogenase activity
G	0004361	molecular_function	glutaryl-CoA dehydrogenase activity
G	0016491	molecular_function	oxidoreductase activity
G	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
G	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G	0046949	biological_process	fatty-acyl-CoA biosynthetic process
G	0050660	molecular_function	flavin adenine dinucleotide binding
H	0000062	molecular_function	fatty-acyl-CoA binding
H	0000166	molecular_function	nucleotide binding
H	0003995	molecular_function	acyl-CoA dehydrogenase activity
H	0004361	molecular_function	glutaryl-CoA dehydrogenase activity
H	0016491	molecular_function	oxidoreductase activity
H	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
H	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H	0046949	biological_process	fatty-acyl-CoA biosynthetic process
H	0050660	molecular_function	flavin adenine dinucleotide binding
I	0000062	molecular_function	fatty-acyl-CoA binding
I	0000166	molecular_function	nucleotide binding
I	0003995	molecular_function	acyl-CoA dehydrogenase activity
I	0004361	molecular_function	glutaryl-CoA dehydrogenase activity
I	0016491	molecular_function	oxidoreductase activity
I	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
I	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I	0046949	biological_process	fatty-acyl-CoA biosynthetic process
I	0050660	molecular_function	flavin adenine dinucleotide binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAD A 1001

Chain	Residue
A	PHE129
A	THR360
A	THR363
A	TYR364
A	GLU365
A	THR367
A	ASP369
A	PHE385
A	HOH1009
A	HOH1051
A	HOH1054
A	LEU131
A	HOH1068
C	GLN281
D	ARG270
D	THR272
D	PHE273
D	LEU277
D	LYS280
D	ASP338
D	ILE339
D	GLY342
A	THR132
D	HOH3003
D	HOH3009
A	GLY136
A	GLY137
A	SER138
A	TRP163
A	THR165
A	LEU207

site_id	AC2
Number of Residues	29
Details	BINDING SITE FOR RESIDUE FAD C 2001

Chain	Residue
A	GLN281
C	PHE129
C	LEU131
C	THR132
C	GLY136
C	GLY137
C	SER138
C	TRP163
C	THR165
C	LEU207
C	THR360
C	THR363
C	TYR364
C	GLU365
C	THR367
C	ASP369
C	PHE385
C	HOH2003
C	HOH2029
C	HOH2064
E	ARG270
E	THR272
E	PHE273
E	LEU277
E	LYS280
E	ASP338
E	ILE339
E	GLY342
E	HOH4003

site_id	AC3
Number of Residues	29
Details	BINDING SITE FOR RESIDUE FAD D 3001

Chain	Residue
A	ARG270
A	THR272
A	LEU277
A	LYS280
A	ASP338
A	ILE339
A	GLY342
A	HOH1044
A	HOH1048
D	PHE129
D	LEU131
D	THR132
D	GLY136
D	GLY137
D	SER138
D	TRP163
D	THR165
D	LEU207
D	THR360
D	THR363
D	TYR364
D	GLU365
D	THR367
D	ASP369
D	PHE385
D	HOH3004
D	HOH3013
D	HOH3063
E	GLN281

site_id	AC4
Number of Residues	30
Details	BINDING SITE FOR RESIDUE FAD E 4001

Chain	Residue
C	HOH2043
C	HOH2048
D	GLN281
E	PHE129
E	LEU131
E	THR132
E	GLY136
E	GLY137
E	SER138
E	TRP163
E	THR165
E	LEU207
E	THR360
E	THR363
E	TYR364
E	GLU365
E	THR367
E	ASP369
E	PHE385
E	HOH4010
C	ARG270
C	THR272
C	PHE273
C	LEU277
C	LYS280
C	ASP338
C	ILE339
C	GLY342
C	ILE345
C	HOH2042

site_id	AC5
Number of Residues	28
Details	BINDING SITE FOR RESIDUE FAD F 5001

Chain	Residue
F	PHE129
F	LEU131
F	THR132
F	GLY136
F	GLY137
F	SER138
F	TRP163
F	THR165
F	LEU207
F	THR360
F	THR363
F	TYR364
F	THR367
F	ASP369
F	PHE385
F	HOH5004
F	HOH5049
G	ARG270
G	THR272
G	PHE273
G	LEU277
G	LYS280
G	ASP338
G	ILE339
G	GLY342
G	HOH6002
G	HOH6006
I	GLN281

site_id	AC6
Number of Residues	30
Details	BINDING SITE FOR RESIDUE FAD G 6001

Chain	Residue
F	ARG270
F	THR272
F	LYS280
F	ASP338
F	ILE339
F	GLY342
F	ILE345
F	HOH5036
F	HOH5037
F	HOH5042
G	PHE129
G	LEU131
G	THR132
G	GLY136
G	GLY137
G	SER138
G	TRP163
G	THR165
G	LEU207
G	THR360
G	THR363
G	TYR364
G	GLU365
G	THR367
G	ASP369
G	PHE385
G	HOH6047
G	HOH6056
G	HOH6074
H	GLN281

site_id	AC7
Number of Residues	30
Details	BINDING SITE FOR RESIDUE FAD H 7001

Chain	Residue
G	GLN281
H	PHE129
H	LEU131
H	THR132
H	GLY136
H	GLY137
H	SER138
H	TRP163
H	THR165
H	THR360
H	THR363
H	TYR364
H	GLU365
H	THR367
H	ASP369
H	PHE385
H	HOH7006
H	HOH7051
H	HOH7060
H	HOH7066
I	ARG270
I	THR272
I	LEU277
I	LYS280
I	ASP338
I	ILE339
I	GLY342
I	HOH8008
I	HOH8010
I	HOH8014

site_id	AC8
Number of Residues	30
Details	BINDING SITE FOR RESIDUE FAD I 8001

Chain	Residue
F	GLN281
H	ARG270
H	THR272
H	PHE273
H	LEU277
H	LYS280
H	ASP338
H	ILE339
H	GLY342
H	HOH7043
H	HOH7047
I	PHE129
I	LEU131
I	THR132
I	GLY136
I	GLY137
I	SER138
I	TRP163
I	THR165
I	LEU207
I	THR360
I	THR363
I	TYR364
I	THR367
I	ASP369
I	PHE385
I	HOH8007
I	HOH8018
I	HOH8061
I	HOH8071

Functional Information from PROSITE/UniProt

site_id	PS00072
Number of Residues	13
Details	ACYL_COA_DH_1 Acyl-CoA dehydrogenases signature 1. GLTEpdGGSDpyG

Chain	Residue	Details
A	GLY130-GLY142

site_id	PS00073
Number of Residues	20
Details	ACYL_COA_DH_2 Acyl-CoA dehydrogenases signature 2. DiLGGsGItlEyhaiRhmlN

Chain	Residue	Details
A	ASP338-ASN357

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
A	ALA244

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
C	GLU365

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
D	GLU365

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
E	GLU365

site_id	CSA13
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
F	GLU365

site_id	CSA14
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
G	GLU365

site_id	CSA15
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
H	GLU365

site_id	CSA16
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
I	GLU365

site_id	CSA17
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
A	ALA249

site_id	CSA18
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
C	ALA249

site_id	CSA19
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
D	ALA249

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
C	ALA244

site_id	CSA20
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
E	ALA249

site_id	CSA21
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
F	ALA249

site_id	CSA22
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
G	ALA249

site_id	CSA23
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
H	ALA249

site_id	CSA24
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
I	ALA249

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
D	ALA244

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
E	ALA244

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
F	ALA244

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
G	ALA244

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
H	ALA244

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
I	ALA244

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
A	GLU365

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)