2E9M

Crystal Structure of human Cytosolic Neutral beta-Glycosylceramidase (Klotho-related Prote:KLrP) complex with Galactose and fatty acids

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004336	molecular_function	galactosylceramidase activity
A	0004348	molecular_function	glucosylceramidase activity
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0004565	molecular_function	beta-galactosidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006629	biological_process	lipid metabolic process
A	0006680	biological_process	glucosylceramide catabolic process
A	0006683	biological_process	galactosylceramide catabolic process
A	0008152	biological_process	metabolic process
A	0008422	molecular_function	beta-glucosidase activity
A	0009313	biological_process	oligosaccharide catabolic process
A	0016139	biological_process	glycoside catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0017042	molecular_function	glycosylceramidase activity
A	0046477	biological_process	glycosylceramide catabolic process
A	0046479	biological_process	glycosphingolipid catabolic process
A	0050821	biological_process	protein stabilization
A	0102483	molecular_function	scopolin beta-glucosidase activity
A	1901805	biological_process	beta-glucoside catabolic process
A	1902494	cellular_component	catalytic complex
A	1903017	biological_process	positive regulation of exo-alpha-sialidase activity

Functional Information from PROSITE/UniProt

site_id	PS00653
Number of Residues	15
Details	GLYCOSYL_HYDROL_F1_2 Glycosyl hydrolases family 1 N-terminal signature. FgWAaAtAAYQvEgG

Chain	Residue	Details
A	PHE7-GLY21

Functional Information from SwissProt/UniProt

Chain	Residue	Details
A	GLU165

Chain	Residue	Details
A	GLU373

Chain	Residue	Details
A	GLU424