2E9M
Crystal Structure of human Cytosolic Neutral beta-Glycosylceramidase (Klotho-related Prote:KLrP) complex with Galactose and fatty acids
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004336 | molecular_function | galactosylceramidase activity |
| A | 0004348 | molecular_function | glucosylceramidase activity |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0004565 | molecular_function | beta-galactosidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006680 | biological_process | glucosylceramide catabolic process |
| A | 0006683 | biological_process | galactosylceramide catabolic process |
| A | 0008422 | molecular_function | beta-glucosidase activity |
| A | 0009313 | biological_process | oligosaccharide catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016139 | biological_process | glycoside catabolic process |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0017042 | molecular_function | glycosylceramidase activity |
| A | 0046477 | biological_process | glycosylceramide catabolic process |
| A | 0046479 | biological_process | glycosphingolipid catabolic process |
| A | 0050821 | biological_process | protein stabilization |
| A | 1901805 | biological_process | beta-glucoside catabolic process |
| A | 1902494 | cellular_component | catalytic complex |
| A | 1903017 | biological_process | positive regulation of exo-alpha-sialidase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00653 |
| Number of Residues | 15 |
| Details | GLYCOSYL_HYDROL_F1_2 Glycosyl hydrolases family 1 N-terminal signature. FgWAaAtAAYQvEgG |
| Chain | Residue | Details |
| A | PHE7-GLY21 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU165 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU373 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLN17 | |
| A | HIS120 | |
| A | ASN164 | |
| A | TYR309 | |
| A | TRP417 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU424 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1cbg |
| Chain | Residue | Details |
| A | GLU373 | |
| A | GLU165 | |
| A | GLN307 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1cbg |
| Chain | Residue | Details |
| A | GLU165 | |
| A | GLU373 |
