2E89
Crystal structure of Aquifex aeolicus TilS in a complex with ATP, Magnesium ion, and L-lysine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006400 | biological_process | tRNA modification |
| A | 0008033 | biological_process | tRNA processing |
| A | 0016874 | molecular_function | ligase activity |
| A | 0016879 | molecular_function | ligase activity, forming carbon-nitrogen bonds |
| A | 0032267 | molecular_function | tRNA(Ile)-lysidine synthase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006400 | biological_process | tRNA modification |
| B | 0008033 | biological_process | tRNA processing |
| B | 0016874 | molecular_function | ligase activity |
| B | 0016879 | molecular_function | ligase activity, forming carbon-nitrogen bonds |
| B | 0032267 | molecular_function | tRNA(Ile)-lysidine synthase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006400 | biological_process | tRNA modification |
| C | 0008033 | biological_process | tRNA processing |
| C | 0016874 | molecular_function | ligase activity |
| C | 0016879 | molecular_function | ligase activity, forming carbon-nitrogen bonds |
| C | 0032267 | molecular_function | tRNA(Ile)-lysidine synthase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006400 | biological_process | tRNA modification |
| D | 0008033 | biological_process | tRNA processing |
| D | 0016874 | molecular_function | ligase activity |
| D | 0016879 | molecular_function | ligase activity, forming carbon-nitrogen bonds |
| D | 0032267 | molecular_function | tRNA(Ile)-lysidine synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 601 |
| Chain | Residue |
| C | ASP36 |
| C | ALA132 |
| C | HIS134 |
| C | ASP137 |
| C | ATP902 |
| C | HOH932 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LYS B 950 |
| Chain | Residue |
| B | VAL189 |
| B | ASP191 |
| B | VAL35 |
| B | LYS182 |
| B | TRP188 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ATP A 900 |
| Chain | Residue |
| A | ALA30 |
| A | PHE31 |
| A | SER32 |
| A | ALA59 |
| A | PHE61 |
| A | ARG110 |
| A | ARG113 |
| A | THR131 |
| A | ALA132 |
| A | HIS133 |
| A | ARG201 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ATP B 901 |
| Chain | Residue |
| B | ALA30 |
| B | PHE31 |
| B | SER32 |
| B | ALA59 |
| B | HIS60 |
| B | PHE61 |
| B | ARG110 |
| B | ARG113 |
| B | THR131 |
| B | ALA132 |
| B | HIS133 |
| B | ARG201 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ATP C 902 |
| Chain | Residue |
| C | ALA30 |
| C | PHE31 |
| C | SER32 |
| C | ALA59 |
| C | HIS60 |
| C | PHE61 |
| C | ARG110 |
| C | ARG113 |
| C | THR131 |
| C | ALA132 |
| C | HIS133 |
| C | MG601 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ATP D 903 |
| Chain | Residue |
| D | ALA30 |
| D | PHE31 |
| D | SER32 |
| D | ASP36 |
| D | ALA59 |
| D | HIS60 |
| D | PHE61 |
| D | ARG113 |
| D | THR131 |
| D | ALA132 |
| D | HIS133 |
| D | ARG201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01161 |
| Chain | Residue | Details |
| A | SER32 | |
| B | SER32 | |
| C | SER32 | |
| D | SER32 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kp2 |
| Chain | Residue | Details |
| A | ARG110 | |
| A | ASP137 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kp2 |
| Chain | Residue | Details |
| B | ARG110 | |
| B | ASP137 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kp2 |
| Chain | Residue | Details |
| C | ARG110 | |
| C | ASP137 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kp2 |
| Chain | Residue | Details |
| D | ARG110 | |
| D | ASP137 |
