2E6M

structure of mouse werner exonuclease domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0008408	molecular_function	3'-5' exonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 501

Chain	Residue
A	LYS119
A	LEU171
A	ASN172
A	LYS185
A	HOH620
A	HOH621
A	HOH622

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:17229737, ECO:0007744|PDB:2E6L

Chain	Residue	Details
A	ASP76
A	GLU78
A	ASP210

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Interaction with DNA => ECO:0000250|UniProtKB:Q14191

Chain	Residue	Details
A	TRP139

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site_id	SWS_FT_FI3
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:Q14191

Chain	Residue	Details
A	LYS235
A	LYS148

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