2E4A

Crystal Structure of Human D-Amino Acid Oxidase in complex with o-aminobenzoate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003884	molecular_function	D-amino-acid oxidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005741	cellular_component	mitochondrial outer membrane
A	0005782	cellular_component	peroxisomal matrix
A	0005829	cellular_component	cytosol
A	0006551	biological_process	L-leucine metabolic process
A	0006562	biological_process	L-proline catabolic process
A	0007586	biological_process	digestion
A	0008718	molecular_function	D-amino-acid dehydrogenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0019478	biological_process	D-amino acid catabolic process
A	0036088	biological_process	D-serine catabolic process
A	0042416	biological_process	dopamine biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0043799	molecular_function	glycine oxidase activity
A	0046416	biological_process	D-amino acid metabolic process
A	0048786	cellular_component	presynaptic active zone
A	0051873	biological_process	killing by host of symbiont cells
A	0055130	biological_process	D-alanine catabolic process
A	0070178	biological_process	D-serine metabolic process
A	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
A	0071949	molecular_function	FAD binding
A	0170035	biological_process	L-amino acid catabolic process
A	0170040	biological_process	proteinogenic amino acid catabolic process
B	0003884	molecular_function	D-amino-acid oxidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005741	cellular_component	mitochondrial outer membrane
B	0005782	cellular_component	peroxisomal matrix
B	0005829	cellular_component	cytosol
B	0006551	biological_process	L-leucine metabolic process
B	0006562	biological_process	L-proline catabolic process
B	0007586	biological_process	digestion
B	0008718	molecular_function	D-amino-acid dehydrogenase activity
B	0016491	molecular_function	oxidoreductase activity
B	0019478	biological_process	D-amino acid catabolic process
B	0036088	biological_process	D-serine catabolic process
B	0042416	biological_process	dopamine biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0043799	molecular_function	glycine oxidase activity
B	0046416	biological_process	D-amino acid metabolic process
B	0048786	cellular_component	presynaptic active zone
B	0051873	biological_process	killing by host of symbiont cells
B	0055130	biological_process	D-alanine catabolic process
B	0070178	biological_process	D-serine metabolic process
B	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
B	0071949	molecular_function	FAD binding
B	0170035	biological_process	L-amino acid catabolic process
B	0170040	biological_process	proteinogenic amino acid catabolic process
C	0003884	molecular_function	D-amino-acid oxidase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005741	cellular_component	mitochondrial outer membrane
C	0005782	cellular_component	peroxisomal matrix
C	0005829	cellular_component	cytosol
C	0006551	biological_process	L-leucine metabolic process
C	0006562	biological_process	L-proline catabolic process
C	0007586	biological_process	digestion
C	0008718	molecular_function	D-amino-acid dehydrogenase activity
C	0016491	molecular_function	oxidoreductase activity
C	0019478	biological_process	D-amino acid catabolic process
C	0036088	biological_process	D-serine catabolic process
C	0042416	biological_process	dopamine biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0043799	molecular_function	glycine oxidase activity
C	0046416	biological_process	D-amino acid metabolic process
C	0048786	cellular_component	presynaptic active zone
C	0051873	biological_process	killing by host of symbiont cells
C	0055130	biological_process	D-alanine catabolic process
C	0070178	biological_process	D-serine metabolic process
C	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
C	0071949	molecular_function	FAD binding
C	0170035	biological_process	L-amino acid catabolic process
C	0170040	biological_process	proteinogenic amino acid catabolic process
D	0003884	molecular_function	D-amino-acid oxidase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0005741	cellular_component	mitochondrial outer membrane
D	0005782	cellular_component	peroxisomal matrix
D	0005829	cellular_component	cytosol
D	0006551	biological_process	L-leucine metabolic process
D	0006562	biological_process	L-proline catabolic process
D	0007586	biological_process	digestion
D	0008718	molecular_function	D-amino-acid dehydrogenase activity
D	0016491	molecular_function	oxidoreductase activity
D	0019478	biological_process	D-amino acid catabolic process
D	0036088	biological_process	D-serine catabolic process
D	0042416	biological_process	dopamine biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0043799	molecular_function	glycine oxidase activity
D	0046416	biological_process	D-amino acid metabolic process
D	0048786	cellular_component	presynaptic active zone
D	0051873	biological_process	killing by host of symbiont cells
D	0055130	biological_process	D-alanine catabolic process
D	0070178	biological_process	D-serine metabolic process
D	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
D	0071949	molecular_function	FAD binding
D	0170035	biological_process	L-amino acid catabolic process
D	0170040	biological_process	proteinogenic amino acid catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	BINDING SITE FOR RESIDUE FAD A 351

Chain	Residue
A	GLY7
A	ALA48
A	GLY50
A	LEU51
A	ARG162
A	LYS163
A	VAL164
A	THR182
A	GLY183
A	TRP185
A	ARG283
A	GLY9
A	GLY312
A	GLY313
A	TYR314
A	GLY315
A	LEU316
A	THR317
A	BE2352
A	HOH380
A	VAL10
A	ILE11
A	ASP37
A	ARG38
A	THR43
A	THR44
A	THR45

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BE2 A 352

Chain	Residue
A	TYR224
A	TYR228
A	ILE230
A	ARG283
A	GLY313
A	FAD351

---

site_id	AC3
Number of Residues	28
Details	BINDING SITE FOR RESIDUE FAD B 1351

Chain	Residue
B	HOH47
B	HOH83
B	HOH89
B	GLY1007
B	ALA1008
B	GLY1009
B	VAL1010
B	ILE1011
B	ASP1037
B	ARG1038
B	THR1044
B	THR1045
B	ALA1048
B	GLY1050
B	LEU1051
B	ARG1162
B	VAL1164
B	THR1182
B	GLY1183
B	TRP1185
B	ARG1283
B	GLY1312
B	GLY1313
B	TYR1314
B	GLY1315
B	LEU1316
B	THR1317
B	BE21352

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BE2 B 1352

Chain	Residue
B	TYR1224
B	TYR1228
B	ILE1230
B	ARG1283
B	GLY1313
B	FAD1351

---

site_id	AC5
Number of Residues	29
Details	BINDING SITE FOR RESIDUE FAD C 2351

Chain	Residue
C	HOH54
C	GLY2007
C	GLY2009
C	VAL2010
C	ILE2011
C	ASP2037
C	ARG2038
C	THR2043
C	THR2044
C	THR2045
C	ALA2048
C	GLY2050
C	LEU2051
C	ARG2162
C	LYS2163
C	VAL2164
C	THR2182
C	GLY2183
C	TRP2185
C	LEU2189
C	ARG2283
C	PRO2284
C	GLY2312
C	GLY2313
C	TYR2314
C	GLY2315
C	LEU2316
C	THR2317
C	BE22352

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BE2 C 2352

Chain	Residue
C	ILE2230
C	ARG2283
C	GLY2313
C	FAD2351
C	LEU2215
C	TYR2224
C	TYR2228

---

site_id	AC7
Number of Residues	30
Details	BINDING SITE FOR RESIDUE FAD D 3351

Chain	Residue
D	HOH49
D	HOH92
D	GLY3007
D	ALA3008
D	GLY3009
D	VAL3010
D	ILE3011
D	ALA3036
D	ASP3037
D	ARG3038
D	THR3043
D	THR3044
D	THR3045
D	ALA3048
D	GLY3050
D	LEU3051
D	ARG3162
D	VAL3164
D	THR3182
D	GLY3183
D	LEU3189
D	ARG3283
D	PRO3284
D	GLY3312
D	GLY3313
D	TYR3314
D	GLY3315
D	LEU3316
D	THR3317
D	BE23352

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BE2 D 3352

Chain	Residue
D	TYR3224
D	TYR3228
D	ILE3230
D	ARG3283
D	GLY3313
D	FAD3351

---

Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	11
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. Pg.TQtVTLGGI

Chain	Residue	Details
A	PRO231-ILE241

---

site_id	PS00677
Number of Residues	19
Details	DAO D-amino acid oxidases signature. VIHNYGhGGyGltihwGcA

Chain	Residue	Details
A	VAL305-ALA323

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Region: {"description":"Required for protein stability","evidences":[{"source":"PubMed","id":"33484270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	Region: {"description":"Active site lid that may open upon substrate/product migration in and out of the active site and close to increase the hydrophobicity of the active site, to make the hydride transfer reaction more efficient","evidences":[{"source":"UniProtKB","id":"P00371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19438227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30265959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32730563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38035964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3G3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HY5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19438227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30265959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38035964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3G3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HY5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19438227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30265959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32730563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38035964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3G3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HY5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19438227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30265959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32730563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38035964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3G3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HY5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19438227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30265959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32730563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38035964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3G3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HY5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001371","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19438227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30265959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32730563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38035964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3G3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HY5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19438227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30265959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32730563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482677","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3G3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1c0k

Chain	Residue	Details
A	GLY313

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1c0k

Chain	Residue	Details
B	GLY1313

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1c0k

Chain	Residue	Details
C	GLY2313

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1c0k

Chain	Residue	Details
D	GLY3313

---