2E3Q

Crystal structure of CERT START domain in complex with C18-ceramide (P212121)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008289	molecular_function	lipid binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 18C A 600

Chain	Residue
A	PHE436
A	VAL557
A	LEU568
A	VAL571
A	ALA572
A	GLU575
A	TYR576
A	PHE579
A	ARG442
A	GLU446
A	GLN467
A	HIS469
A	VAL472
A	TYR482
A	ASN504
A	TYR553

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 700

Chain	Residue
A	ILE528
A	GLN530
A	LYS550
A	ILE551
A	THR552
A	HOH717

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:20036255

Chain	Residue	Details
A	VAL472
A	THR493
A	GLN530
A	PHE579

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	GLU372

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	GLU373
A	THR380

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	ASN377

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