2E3O

Crystal structure of CERT START domain in complex with C16-ceramide (P212121)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008289	molecular_function	lipid binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 16C A 600

Chain	Residue
A	PHE436
A	VAL525
A	TYR553
A	LEU568
A	VAL571
A	GLU575
A	TYR576
A	PHE579
A	HOH766
A	ARG442
A	GLU446
A	GLN467
A	HIS469
A	VAL472
A	ALA475
A	TYR482
A	ASN504

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 701

Chain	Residue
A	GLN384
A	ASP385
A	VAL386
A	TYR404
A	LYS419

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 702

Chain	Residue
A	ILE528
A	GLN530
A	LYS550
A	ILE551
A	THR552
A	HOH788

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:20036255

Chain	Residue	Details
A	VAL472
A	THR493
A	GLN530
A	PHE579

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	GLU372

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	GLU373
A	THR380

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	ASN377

---