2E30
Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0001578 | biological_process | microtubule bundle formation |
| A | 0001933 | biological_process | negative regulation of protein phosphorylation |
| A | 0004860 | molecular_function | protein kinase inhibitor activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005793 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0006469 | biological_process | negative regulation of protein kinase activity |
| A | 0006611 | biological_process | protein export from nucleus |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| A | 0008017 | molecular_function | microtubule binding |
| A | 0010560 | biological_process | positive regulation of glycoprotein biosynthetic process |
| A | 0010923 | biological_process | negative regulation of phosphatase activity |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0015031 | biological_process | protein transport |
| A | 0015385 | molecular_function | sodium:proton antiporter activity |
| A | 0015459 | molecular_function | potassium channel regulator activity |
| A | 0015630 | cellular_component | microtubule cytoskeleton |
| A | 0016020 | cellular_component | membrane |
| A | 0019900 | molecular_function | kinase binding |
| A | 0022406 | biological_process | membrane docking |
| A | 0030133 | cellular_component | transport vesicle |
| A | 0031122 | biological_process | cytoplasmic microtubule organization |
| A | 0031397 | biological_process | negative regulation of protein ubiquitination |
| A | 0031953 | biological_process | negative regulation of protein autophosphorylation |
| A | 0032088 | biological_process | negative regulation of NF-kappaB transcription factor activity |
| A | 0032417 | biological_process | positive regulation of sodium:proton antiporter activity |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042306 | biological_process | regulation of protein import into nucleus |
| A | 0042308 | biological_process | negative regulation of protein import into nucleus |
| A | 0045121 | cellular_component | membrane raft |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0050821 | biological_process | protein stabilization |
| A | 0051222 | biological_process | positive regulation of protein transport |
| A | 0051453 | biological_process | regulation of intracellular pH |
| A | 0061024 | biological_process | membrane organization |
| A | 0061025 | biological_process | membrane fusion |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070884 | biological_process | regulation of calcineurin-NFAT signaling cascade |
| A | 0070885 | biological_process | negative regulation of calcineurin-NFAT signaling cascade |
| A | 0071073 | biological_process | positive regulation of phospholipid biosynthetic process |
| A | 0071468 | biological_process | cellular response to acidic pH |
| A | 0090314 | biological_process | positive regulation of protein targeting to membrane |
| A | 1990351 | cellular_component | transporter complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 300 |
| Chain | Residue |
| A | ASP123 |
| A | ASP125 |
| A | LYS126 |
| A | ASP127 |
| A | LYS129 |
| A | GLU134 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CA A 301 |
| Chain | Residue |
| A | GLY167 |
| A | ASP168 |
| A | ALA170 |
| A | ILE171 |
| A | GLU175 |
| A | ASP164 |
| A | GLN165 |
| A | ASP166 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 42 |
| Details | Region: {"description":"Necessary for nuclear export signal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Motif: {"description":"Necessary for association with microtubule and interaction with GAPDH","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 9 |
| Details | Motif: {"description":"Nuclear export signal 1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 9 |
| Details | Motif: {"description":"Nuclear export signal 2","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"N-myristoyl glycine","evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 42 |
| Details | Region: {"description":"Interaction with TESC","evidences":[{"source":"PubMed","id":"30287853","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 7 |
| Details | Region: {"description":"PI(4,5)P2-binding region","evidences":[{"source":"UniProtKB","id":"P26431","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 30 |
| Details | Region: {"description":"Interaction with CHP2","evidences":[{"source":"PubMed","id":"21392185","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 5 |
| Details | Region: {"description":"Confers pH-dependent PI(4,5)P2 binding","evidences":[{"source":"PubMed","id":"27650500","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
