2E21

Crystal structure of TilS in a complex with AMPPNP from Aquifex aeolicus.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006400	biological_process	tRNA modification
A	0008033	biological_process	tRNA processing
A	0016874	molecular_function	ligase activity
A	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
A	0032267	molecular_function	tRNA(Ile)-lysidine synthase activity
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006400	biological_process	tRNA modification
B	0008033	biological_process	tRNA processing
B	0016874	molecular_function	ligase activity
B	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
B	0032267	molecular_function	tRNA(Ile)-lysidine synthase activity
C	0000166	molecular_function	nucleotide binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006400	biological_process	tRNA modification
C	0008033	biological_process	tRNA processing
C	0016874	molecular_function	ligase activity
C	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
C	0032267	molecular_function	tRNA(Ile)-lysidine synthase activity
D	0000166	molecular_function	nucleotide binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006400	biological_process	tRNA modification
D	0008033	biological_process	tRNA processing
D	0016874	molecular_function	ligase activity
D	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
D	0032267	molecular_function	tRNA(Ile)-lysidine synthase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ANP A 500

Chain	Residue
A	ALA30
A	THR131
A	ALA132
A	HIS133
A	ARG201
A	PHE31
A	SER32
A	ALA59
A	PHE61
A	GLU106
A	ARG110
A	ARG113
A	TYR114

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site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ANP C 501

Chain	Residue
C	ALA30
C	PHE31
C	SER32
C	ALA59
C	HIS60
C	PHE61
C	ARG110
C	ARG113
C	THR131
C	ALA132
C	HIS133
C	HOH552

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01161","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1kp2

Chain	Residue	Details
A	ARG110
A	ASP137

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1kp2

Chain	Residue	Details
B	ARG110
B	ASP137

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site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1kp2

Chain	Residue	Details
C	ARG110
C	ASP137

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site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1kp2

Chain	Residue	Details
D	ARG110
D	ASP137

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