2E0N
Crystal structure of CbiL in complex with S-adenosylhomocysteine, a methyltransferase involved in anaerobic vitamin B12 biosynthesis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| A | 0009236 | biological_process | cobalamin biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030788 | molecular_function | precorrin-2 C20-methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| B | 0009236 | biological_process | cobalamin biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030788 | molecular_function | precorrin-2 C20-methyltransferase activity |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAH A 300 |
| Chain | Residue |
| A | PRO14 |
| A | LYS180 |
| A | ALA202 |
| A | LYS204 |
| A | VAL205 |
| A | MET207 |
| A | TYR226 |
| A | PHE227 |
| A | SER228 |
| A | LEU229 |
| A | HOH309 |
| A | VAL104 |
| A | HOH310 |
| A | GLY105 |
| A | ASP106 |
| A | PHE109 |
| A | TYR110 |
| A | PRO134 |
| A | ALA135 |
| A | MET179 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SAH B 301 |
| Chain | Residue |
| B | PRO14 |
| B | VAL104 |
| B | GLY105 |
| B | ASP106 |
| B | PHE109 |
| B | TYR110 |
| B | PRO134 |
| B | ALA135 |
| B | MET179 |
| B | LYS180 |
| B | ALA202 |
| B | LYS204 |
| B | VAL205 |
| B | MET207 |
| B | TYR226 |
| B | PHE227 |
| B | SER228 |
| B | HOH309 |
| B | HOH317 |
Functional Information from PROSITE/UniProt
| site_id | PS00839 |
| Number of Residues | 15 |
| Details | SUMT_1 Uroporphyrin-III C-methyltransferase signature 1. VSLGPGdpgLITVKA |
| Chain | Residue | Details |
| A | VAL10-ALA24 |
