2E00
Crystal structure of N392L mutant of yeast bleomycin hydrolase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003690 | molecular_function | double-stranded DNA binding |
| A | 0003697 | molecular_function | single-stranded DNA binding |
| A | 0003729 | molecular_function | mRNA binding |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0043418 | biological_process | homocysteine catabolic process |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0070005 | molecular_function | cysteine-type aminopeptidase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QKsSGRCWLfAA |
| Chain | Residue | Details |
| A | GLN67-ALA78 |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. MTHAMLITGCH |
| Chain | Residue | Details |
| A | MET367-HIS377 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1gcb |
| Chain | Residue | Details |
| A | LEU392 | |
| A | CYS73 | |
| A | HIS369 | |
| A | GLN67 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 624 |
| Chain | Residue | Details |
| A | GLN67 | electrostatic stabiliser |
| A | CYS73 | electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
| A | HIS369 | proton acceptor, proton donor |
| A | LEU392 | electrostatic stabiliser |
