2DZY
Crystal structure of N392A mutant of yeast bleomycin hydrolase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
A | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
A | 0003677 | molecular_function | DNA binding |
A | 0003690 | molecular_function | double-stranded DNA binding |
A | 0003697 | molecular_function | single-stranded DNA binding |
A | 0003729 | molecular_function | mRNA binding |
A | 0004177 | molecular_function | aminopeptidase activity |
A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0006508 | biological_process | proteolysis |
A | 0008234 | molecular_function | cysteine-type peptidase activity |
A | 0009636 | biological_process | response to toxic substance |
A | 0043418 | biological_process | homocysteine catabolic process |
A | 0046677 | biological_process | response to antibiotic |
A | 0070005 | molecular_function | cysteine-type aminopeptidase activity |
Functional Information from PROSITE/UniProt
site_id | PS00139 |
Number of Residues | 12 |
Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QKsSGRCWLfAA |
Chain | Residue | Details |
A | GLN67-ALA78 |
site_id | PS00639 |
Number of Residues | 11 |
Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. MTHAMLITGCH |
Chain | Residue | Details |
A | MET367-HIS377 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | LEU102 | |
A | SER398 | |
A | ASP421 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1gcb |
Chain | Residue | Details |
A | ALA392 | |
A | CYS73 | |
A | HIS369 | |
A | GLN67 |
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 624 |
Chain | Residue | Details |
A | GLU96 | electrostatic stabiliser |
A | LEU102 | electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
A | SER398 | proton acceptor, proton donor |
A | ASP421 | electrostatic stabiliser |