2DXC
Recombinant thiocyanate hydrolase, fully-matured form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0018760 | molecular_function | thiocyanate hydrolase activity |
| A | 0046265 | biological_process | thiocyanate catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0018760 | molecular_function | thiocyanate hydrolase activity |
| B | 0046265 | biological_process | thiocyanate catabolic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0018760 | molecular_function | thiocyanate hydrolase activity |
| C | 0046265 | biological_process | thiocyanate catabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0046914 | molecular_function | transition metal ion binding |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0018760 | molecular_function | thiocyanate hydrolase activity |
| D | 0046265 | biological_process | thiocyanate catabolic process |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0018760 | molecular_function | thiocyanate hydrolase activity |
| E | 0046265 | biological_process | thiocyanate catabolic process |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0018760 | molecular_function | thiocyanate hydrolase activity |
| F | 0046265 | biological_process | thiocyanate catabolic process |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0046914 | molecular_function | transition metal ion binding |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0018760 | molecular_function | thiocyanate hydrolase activity |
| G | 0046265 | biological_process | thiocyanate catabolic process |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0018760 | molecular_function | thiocyanate hydrolase activity |
| H | 0046265 | biological_process | thiocyanate catabolic process |
| I | 0003824 | molecular_function | catalytic activity |
| I | 0016787 | molecular_function | hydrolase activity |
| I | 0018760 | molecular_function | thiocyanate hydrolase activity |
| I | 0046265 | biological_process | thiocyanate catabolic process |
| I | 0046872 | molecular_function | metal ion binding |
| I | 0046914 | molecular_function | transition metal ion binding |
| J | 0016787 | molecular_function | hydrolase activity |
| J | 0018760 | molecular_function | thiocyanate hydrolase activity |
| J | 0046265 | biological_process | thiocyanate catabolic process |
| K | 0016787 | molecular_function | hydrolase activity |
| K | 0018760 | molecular_function | thiocyanate hydrolase activity |
| K | 0046265 | biological_process | thiocyanate catabolic process |
| L | 0003824 | molecular_function | catalytic activity |
| L | 0016787 | molecular_function | hydrolase activity |
| L | 0018760 | molecular_function | thiocyanate hydrolase activity |
| L | 0046265 | biological_process | thiocyanate catabolic process |
| L | 0046872 | molecular_function | metal ion binding |
| L | 0046914 | molecular_function | transition metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 3CO C 301 |
| Chain | Residue |
| C | CYS128 |
| C | CSD131 |
| C | SER132 |
| C | CSO133 |
| C | TLA3001 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 3CO F 301 |
| Chain | Residue |
| F | CSO133 |
| E | TLA3002 |
| F | CYS128 |
| F | CSD131 |
| F | SER132 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 3CO I 301 |
| Chain | Residue |
| I | CYS128 |
| I | CSD131 |
| I | SER132 |
| I | CSO133 |
| I | TLA3003 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 3CO L 301 |
| Chain | Residue |
| L | CYS128 |
| L | CSD131 |
| L | SER132 |
| L | CSO133 |
| L | TLA3004 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TLA C 3001 |
| Chain | Residue |
| B | ARG90 |
| B | ARG91 |
| B | GLN94 |
| B | ASN95 |
| B | TYR108 |
| B | TRP112 |
| C | SER108 |
| C | CSD131 |
| C | SER132 |
| C | CSO133 |
| C | ARG136 |
| C | 3CO301 |
| C | HOH3009 |
| C | HOH3020 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE TLA E 3002 |
| Chain | Residue |
| E | ARG90 |
| E | ARG91 |
| E | GLN94 |
| E | ASN95 |
| E | TYR108 |
| E | TRP112 |
| F | SER108 |
| F | CSD131 |
| F | SER132 |
| F | CSO133 |
| F | ARG136 |
| F | 3CO301 |
| F | HOH330 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE TLA I 3003 |
| Chain | Residue |
| H | ARG90 |
| H | ARG91 |
| H | GLN94 |
| H | ASN95 |
| H | TYR108 |
| H | TRP112 |
| I | CSD131 |
| I | SER132 |
| I | CSO133 |
| I | ARG136 |
| I | 3CO301 |
| I | HOH3014 |
| I | HOH3034 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TLA L 3004 |
| Chain | Residue |
| K | ARG90 |
| K | ARG91 |
| K | GLN94 |
| K | ASN95 |
| K | TYR108 |
| K | TRP112 |
| L | SER108 |
| L | CSD131 |
| L | SER132 |
| L | CSO133 |
| L | ARG136 |
| L | 3CO301 |
| L | HOH3014 |
| L | HOH3028 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0007744|PDB:2DD5 |
| Chain | Residue | Details |
| C | THR129 | |
| I | SER132 | |
| I | CSO133 | |
| I | TYR134 | |
| L | THR129 | |
| L | SER132 | |
| L | CSO133 | |
| L | TYR134 | |
| C | SER132 | |
| C | CSO133 | |
| C | TYR134 | |
| F | THR129 | |
| F | SER132 | |
| F | CSO133 | |
| F | TYR134 | |
| I | THR129 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Cysteine sulfinic acid (-SO2H) => ECO:0000269|PubMed:16417356, ECO:0000269|PubMed:16879822, ECO:0000269|PubMed:17222425 |
| Chain | Residue | Details |
| C | SER132 | |
| F | SER132 | |
| I | SER132 | |
| L | SER132 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Cysteine sulfenic acid (-SOH) => ECO:0000269|PubMed:16879822, ECO:0000269|PubMed:17222425 |
| Chain | Residue | Details |
| C | TYR134 | |
| F | TYR134 | |
| I | TYR134 | |
| L | TYR134 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ahj |
| Chain | Residue | Details |
| H | ARG91 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ahj |
| Chain | Residue | Details |
| K | ARG91 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ahj |
| Chain | Residue | Details |
| E | ARG91 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ahj |
| Chain | Residue | Details |
| B | ARG91 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 284 |
| Chain | Residue | Details |
| C | THR129 | activator, electrostatic stabiliser, metal ligand |
| C | SER132 | electrostatic stabiliser, metal ligand |
| C | CSO133 | electrostatic stabiliser, metal ligand |
| C | TYR134 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, metal ligand |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 284 |
| Chain | Residue | Details |
| F | THR129 | activator, electrostatic stabiliser, metal ligand |
| F | SER132 | electrostatic stabiliser, metal ligand |
| F | CSO133 | electrostatic stabiliser, metal ligand |
| F | TYR134 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, metal ligand |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 284 |
| Chain | Residue | Details |
| I | THR129 | activator, electrostatic stabiliser, metal ligand |
| I | SER132 | electrostatic stabiliser, metal ligand |
| I | CSO133 | electrostatic stabiliser, metal ligand |
| I | TYR134 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, metal ligand |
| site_id | MCSA4 |
| Number of Residues | 4 |
| Details | M-CSA 284 |
| Chain | Residue | Details |
| L | THR129 | activator, electrostatic stabiliser, metal ligand |
| L | SER132 | electrostatic stabiliser, metal ligand |
| L | CSO133 | electrostatic stabiliser, metal ligand |
| L | TYR134 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, metal ligand |
