2DXC

Recombinant thiocyanate hydrolase, fully-matured form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
A	0018760	molecular_function	thiocyanate hydrolase activity
A	0046265	biological_process	thiocyanate catabolic process
B	0016787	molecular_function	hydrolase activity
B	0018760	molecular_function	thiocyanate hydrolase activity
B	0046265	biological_process	thiocyanate catabolic process
C	0003824	molecular_function	catalytic activity
C	0016787	molecular_function	hydrolase activity
C	0018760	molecular_function	thiocyanate hydrolase activity
C	0046265	biological_process	thiocyanate catabolic process
C	0046872	molecular_function	metal ion binding
C	0046914	molecular_function	transition metal ion binding
D	0016787	molecular_function	hydrolase activity
D	0018760	molecular_function	thiocyanate hydrolase activity
D	0046265	biological_process	thiocyanate catabolic process
E	0016787	molecular_function	hydrolase activity
E	0018760	molecular_function	thiocyanate hydrolase activity
E	0046265	biological_process	thiocyanate catabolic process
F	0003824	molecular_function	catalytic activity
F	0016787	molecular_function	hydrolase activity
F	0018760	molecular_function	thiocyanate hydrolase activity
F	0046265	biological_process	thiocyanate catabolic process
F	0046872	molecular_function	metal ion binding
F	0046914	molecular_function	transition metal ion binding
G	0016787	molecular_function	hydrolase activity
G	0018760	molecular_function	thiocyanate hydrolase activity
G	0046265	biological_process	thiocyanate catabolic process
H	0016787	molecular_function	hydrolase activity
H	0018760	molecular_function	thiocyanate hydrolase activity
H	0046265	biological_process	thiocyanate catabolic process
I	0003824	molecular_function	catalytic activity
I	0016787	molecular_function	hydrolase activity
I	0018760	molecular_function	thiocyanate hydrolase activity
I	0046265	biological_process	thiocyanate catabolic process
I	0046872	molecular_function	metal ion binding
I	0046914	molecular_function	transition metal ion binding
J	0016787	molecular_function	hydrolase activity
J	0018760	molecular_function	thiocyanate hydrolase activity
J	0046265	biological_process	thiocyanate catabolic process
K	0016787	molecular_function	hydrolase activity
K	0018760	molecular_function	thiocyanate hydrolase activity
K	0046265	biological_process	thiocyanate catabolic process
L	0003824	molecular_function	catalytic activity
L	0016787	molecular_function	hydrolase activity
L	0018760	molecular_function	thiocyanate hydrolase activity
L	0046265	biological_process	thiocyanate catabolic process
L	0046872	molecular_function	metal ion binding
L	0046914	molecular_function	transition metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 3CO C 301

Chain	Residue
C	CYS128
C	CSD131
C	SER132
C	CSO133
C	TLA3001

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 3CO F 301

Chain	Residue
F	CSO133
E	TLA3002
F	CYS128
F	CSD131
F	SER132

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 3CO I 301

Chain	Residue
I	CYS128
I	CSD131
I	SER132
I	CSO133
I	TLA3003

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 3CO L 301

Chain	Residue
L	CYS128
L	CSD131
L	SER132
L	CSO133
L	TLA3004

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE TLA C 3001

Chain	Residue
B	ARG90
B	ARG91
B	GLN94
B	ASN95
B	TYR108
B	TRP112
C	SER108
C	CSD131
C	SER132
C	CSO133
C	ARG136
C	3CO301
C	HOH3009
C	HOH3020

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TLA E 3002

Chain	Residue
E	ARG90
E	ARG91
E	GLN94
E	ASN95
E	TYR108
E	TRP112
F	SER108
F	CSD131
F	SER132
F	CSO133
F	ARG136
F	3CO301
F	HOH330

---

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TLA I 3003

Chain	Residue
H	ARG90
H	ARG91
H	GLN94
H	ASN95
H	TYR108
H	TRP112
I	CSD131
I	SER132
I	CSO133
I	ARG136
I	3CO301
I	HOH3014
I	HOH3034

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE TLA L 3004

Chain	Residue
K	ARG90
K	ARG91
K	GLN94
K	ASN95
K	TYR108
K	TRP112
L	SER108
L	CSD131
L	SER132
L	CSO133
L	ARG136
L	3CO301
L	HOH3014
L	HOH3028

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PDB","id":"2DD5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Cysteine sulfinic acid (-SO2H)","evidences":[{"source":"PubMed","id":"16417356","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16879822","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17222425","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Cysteine sulfenic acid (-SOH)","evidences":[{"source":"PubMed","id":"16879822","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17222425","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ahj

Chain	Residue	Details
H	ARG91

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ahj

Chain	Residue	Details
K	ARG91

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ahj

Chain	Residue	Details
E	ARG91

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ahj

Chain	Residue	Details
B	ARG91

---

site_id	MCSA1
Number of Residues	4
Details	M-CSA 284

Chain	Residue	Details
C	CYS128	activator, electrostatic stabiliser, metal ligand
C	SER132	electrostatic stabiliser, metal ligand
C	CSO133	electrostatic stabiliser, metal ligand
C	ILE138	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, metal ligand

---

site_id	MCSA2
Number of Residues	4
Details	M-CSA 284

Chain	Residue	Details
F	CYS128	activator, electrostatic stabiliser, metal ligand
F	SER132	electrostatic stabiliser, metal ligand
F	CSO133	electrostatic stabiliser, metal ligand
F	ILE138	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, metal ligand

---

site_id	MCSA3
Number of Residues	4
Details	M-CSA 284

Chain	Residue	Details
I	CYS128	activator, electrostatic stabiliser, metal ligand
I	SER132	electrostatic stabiliser, metal ligand
I	CSO133	electrostatic stabiliser, metal ligand
I	ILE138	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, metal ligand

---

site_id	MCSA4
Number of Residues	4
Details	M-CSA 284

Chain	Residue	Details
L	CYS128	activator, electrostatic stabiliser, metal ligand
L	SER132	electrostatic stabiliser, metal ligand
L	CSO133	electrostatic stabiliser, metal ligand
L	ILE138	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, metal ligand

---