2DX5

The complex structure between the mouse EAP45-GLUE domain and ubiquitin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000814	cellular_component	ESCRT II complex
A	0032266	molecular_function	phosphatidylinositol-3-phosphate binding
A	0032509	biological_process	endosome transport via multivesicular body sorting pathway
A	0043130	molecular_function	ubiquitin binding

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
B	LYS27-ASP52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
B	ARG54
B	ARG72

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Essential for function

Chain	Residue	Details
B	HIS68

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P0CG48

Chain	Residue	Details
B	SER65

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: ADP-ribosylglycine => ECO:0000250|UniProtKB:P0CG48

Chain	Residue	Details
B	GLY76

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site_id	SWS_FT_FI5
Number of Residues	7
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48

Chain	Residue	Details
B	LYS6
B	LYS11
B	LYS27
B	LYS29
B	LYS33
B	LYS48
B	LYS63

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site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214

Chain	Residue	Details
B	GLY76

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