2DW4
Crystal structure of human LSD1 at 2.3 A resolution
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 40 |
| Details | BINDING SITE FOR RESIDUE FAD A 1001 |
| Chain | Residue |
| A | GLY285 |
| A | GLY315 |
| A | ARG316 |
| A | LEU329 |
| A | GLY330 |
| A | ALA331 |
| A | MET332 |
| A | VAL333 |
| A | THR588 |
| A | VAL590 |
| A | THR624 |
| A | GLY287 |
| A | LEU625 |
| A | PRO626 |
| A | LEU659 |
| A | TRP751 |
| A | TRP756 |
| A | SER760 |
| A | TYR761 |
| A | GLY800 |
| A | GLU801 |
| A | ALA809 |
| A | VAL288 |
| A | THR810 |
| A | VAL811 |
| A | ALA814 |
| A | HOH1014 |
| A | HOH1032 |
| A | HOH1251 |
| A | HOH1252 |
| A | HOH1254 |
| A | HOH1257 |
| A | HOH1262 |
| A | SER289 |
| A | HOH1263 |
| A | LEU307 |
| A | GLU308 |
| A | ALA309 |
| A | ARG310 |
| A | GLY314 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0007744|PDB:2DW4, ECO:0007744|PDB:2H94, ECO:0007744|PDB:2HKO, ECO:0007744|PDB:2IW5, ECO:0007744|PDB:2V1D, ECO:0007744|PDB:2X0L, ECO:0007744|PDB:2XAF, ECO:0007744|PDB:2XAG, ECO:0007744|PDB:2XAH, ECO:0007744|PDB:2XAJ, ECO:0007744|PDB:2XAQ, ECO:0007744|PDB:2XAS, ECO:0007744|PDB:2Y48, ECO:0007744|PDB:3ZMS, ECO:0007744|PDB:3ZMT, ECO:0007744|PDB:3ZMU, ECO:0007744|PDB:3ZMV, ECO:0007744|PDB:3ZMZ, ECO:0007744|PDB:3ZN0, ECO:0007744|PDB:3ZN1 |
| Chain | Residue | Details |
| A | SER289 | |
| A | GLU308 | |
| A | ARG310 | |
| A | ARG316 | |
| A | MET332 | |
| A | GLU801 | |
| A | THR810 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:27292636 |
| Chain | Residue | Details |
| A | LYS432 | |
| A | LYS433 | |
| A | LYS436 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER611 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS442 | |
| A | LYS469 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:25018020 |
| Chain | Residue | Details |
| A | LYS503 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1f8r |
| Chain | Residue | Details |
| A | THR335 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1f8r |
| Chain | Residue | Details |
| A | LYS661 | |
| A | HIS551 |
