2DU8
Crystal structure of human D-amino acid oxidase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003884 | molecular_function | D-amino-acid oxidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005777 | cellular_component | peroxisome |
| A | 0005782 | cellular_component | peroxisomal matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0006562 | biological_process | proline catabolic process |
| A | 0007586 | biological_process | digestion |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019478 | biological_process | D-amino acid catabolic process |
| A | 0036088 | biological_process | D-serine catabolic process |
| A | 0042416 | biological_process | dopamine biosynthetic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042995 | cellular_component | cell projection |
| A | 0045202 | cellular_component | synapse |
| A | 0046416 | biological_process | D-amino acid metabolic process |
| A | 0048786 | cellular_component | presynaptic active zone |
| A | 0055130 | biological_process | D-alanine catabolic process |
| A | 0070178 | biological_process | D-serine metabolic process |
| A | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
| A | 0071949 | molecular_function | FAD binding |
| B | 0003884 | molecular_function | D-amino-acid oxidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005741 | cellular_component | mitochondrial outer membrane |
| B | 0005777 | cellular_component | peroxisome |
| B | 0005782 | cellular_component | peroxisomal matrix |
| B | 0005829 | cellular_component | cytosol |
| B | 0006562 | biological_process | proline catabolic process |
| B | 0007586 | biological_process | digestion |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019478 | biological_process | D-amino acid catabolic process |
| B | 0036088 | biological_process | D-serine catabolic process |
| B | 0042416 | biological_process | dopamine biosynthetic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042995 | cellular_component | cell projection |
| B | 0045202 | cellular_component | synapse |
| B | 0046416 | biological_process | D-amino acid metabolic process |
| B | 0048786 | cellular_component | presynaptic active zone |
| B | 0055130 | biological_process | D-alanine catabolic process |
| B | 0070178 | biological_process | D-serine metabolic process |
| B | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
| B | 0071949 | molecular_function | FAD binding |
| G | 0003884 | molecular_function | D-amino-acid oxidase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005576 | cellular_component | extracellular region |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005741 | cellular_component | mitochondrial outer membrane |
| G | 0005777 | cellular_component | peroxisome |
| G | 0005782 | cellular_component | peroxisomal matrix |
| G | 0005829 | cellular_component | cytosol |
| G | 0006562 | biological_process | proline catabolic process |
| G | 0007586 | biological_process | digestion |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0019478 | biological_process | D-amino acid catabolic process |
| G | 0036088 | biological_process | D-serine catabolic process |
| G | 0042416 | biological_process | dopamine biosynthetic process |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0042995 | cellular_component | cell projection |
| G | 0045202 | cellular_component | synapse |
| G | 0046416 | biological_process | D-amino acid metabolic process |
| G | 0048786 | cellular_component | presynaptic active zone |
| G | 0055130 | biological_process | D-alanine catabolic process |
| G | 0070178 | biological_process | D-serine metabolic process |
| G | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
| G | 0071949 | molecular_function | FAD binding |
| J | 0003884 | molecular_function | D-amino-acid oxidase activity |
| J | 0005515 | molecular_function | protein binding |
| J | 0005576 | cellular_component | extracellular region |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0005741 | cellular_component | mitochondrial outer membrane |
| J | 0005777 | cellular_component | peroxisome |
| J | 0005782 | cellular_component | peroxisomal matrix |
| J | 0005829 | cellular_component | cytosol |
| J | 0006562 | biological_process | proline catabolic process |
| J | 0007586 | biological_process | digestion |
| J | 0016491 | molecular_function | oxidoreductase activity |
| J | 0019478 | biological_process | D-amino acid catabolic process |
| J | 0036088 | biological_process | D-serine catabolic process |
| J | 0042416 | biological_process | dopamine biosynthetic process |
| J | 0042802 | molecular_function | identical protein binding |
| J | 0042995 | cellular_component | cell projection |
| J | 0045202 | cellular_component | synapse |
| J | 0046416 | biological_process | D-amino acid metabolic process |
| J | 0048786 | cellular_component | presynaptic active zone |
| J | 0055130 | biological_process | D-alanine catabolic process |
| J | 0070178 | biological_process | D-serine metabolic process |
| J | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
| J | 0071949 | molecular_function | FAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE FAD A 351 |
| Chain | Residue |
| A | GLY7 |
| A | THR44 |
| A | THR45 |
| A | ALA48 |
| A | GLY50 |
| A | LEU51 |
| A | ARG162 |
| A | LYS163 |
| A | VAL164 |
| A | CYS181 |
| A | THR182 |
| A | ALA8 |
| A | GLY183 |
| A | TRP185 |
| A | GLY281 |
| A | GLY312 |
| A | GLY313 |
| A | TYR314 |
| A | GLY315 |
| A | LEU316 |
| A | THR317 |
| A | BEZ352 |
| A | GLY9 |
| A | HOH357 |
| A | HOH359 |
| A | HOH367 |
| A | VAL10 |
| A | ILE11 |
| A | ALA36 |
| A | ASP37 |
| A | ARG38 |
| A | THR43 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BEZ A 352 |
| Chain | Residue |
| A | TYR224 |
| A | TYR228 |
| A | ARG283 |
| A | GLY313 |
| A | FAD351 |
| site_id | AC3 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE FAD B 1351 |
| Chain | Residue |
| B | HOH4 |
| B | HOH29 |
| B | HOH98 |
| B | HOH107 |
| B | HOH170 |
| B | ILE1006 |
| B | GLY1007 |
| B | ALA1008 |
| B | GLY1009 |
| B | VAL1010 |
| B | ILE1011 |
| B | ALA1036 |
| B | ASP1037 |
| B | ARG1038 |
| B | THR1044 |
| B | THR1045 |
| B | ALA1048 |
| B | GLY1050 |
| B | LEU1051 |
| B | ARG1162 |
| B | LYS1163 |
| B | VAL1164 |
| B | CYS1181 |
| B | THR1182 |
| B | GLY1183 |
| B | TRP1185 |
| B | ILE1202 |
| B | GLY1281 |
| B | ARG1283 |
| B | GLY1312 |
| B | GLY1313 |
| B | TYR1314 |
| B | GLY1315 |
| B | LEU1316 |
| B | THR1317 |
| B | BEZ1352 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BEZ B 1352 |
| Chain | Residue |
| B | TYR1224 |
| B | TYR1228 |
| B | ILE1230 |
| B | ARG1283 |
| B | GLY1313 |
| B | FAD1351 |
| site_id | AC5 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD G 2351 |
| Chain | Residue |
| G | CYS2181 |
| G | THR2182 |
| G | TRP2185 |
| G | ILE2202 |
| G | GLY2281 |
| G | ARG2283 |
| G | GLY2312 |
| G | GLY2313 |
| G | TYR2314 |
| G | GLY2315 |
| G | LEU2316 |
| G | THR2317 |
| G | BEZ2352 |
| G | HOH1 |
| G | HOH12 |
| G | HOH91 |
| G | GLY2007 |
| G | ALA2008 |
| G | GLY2009 |
| G | VAL2010 |
| G | ILE2011 |
| G | ALA2036 |
| G | ASP2037 |
| G | ARG2038 |
| G | THR2044 |
| G | THR2045 |
| G | ALA2048 |
| G | ALA2049 |
| G | GLY2050 |
| G | LEU2051 |
| G | ARG2162 |
| G | LYS2163 |
| G | VAL2164 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BEZ G 2352 |
| Chain | Residue |
| G | TYR2224 |
| G | TYR2228 |
| G | ARG2283 |
| G | GLY2313 |
| G | FAD2351 |
| site_id | AC7 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD J 3351 |
| Chain | Residue |
| J | HOH67 |
| J | HOH70 |
| J | HOH117 |
| J | HOH173 |
| J | GLY3007 |
| J | ALA3008 |
| J | GLY3009 |
| J | VAL3010 |
| J | ILE3011 |
| J | ALA3036 |
| J | ASP3037 |
| J | ARG3038 |
| J | THR3044 |
| J | THR3045 |
| J | ALA3048 |
| J | GLY3050 |
| J | LEU3051 |
| J | ARG3162 |
| J | LYS3163 |
| J | VAL3164 |
| J | THR3182 |
| J | GLY3183 |
| J | TRP3185 |
| J | GLY3281 |
| J | ARG3283 |
| J | HIS3311 |
| J | GLY3312 |
| J | GLY3313 |
| J | TYR3314 |
| J | GLY3315 |
| J | LEU3316 |
| J | THR3317 |
| J | BEZ3352 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BEZ J 3352 |
| Chain | Residue |
| J | TYR3224 |
| J | TYR3228 |
| J | ARG3283 |
| J | GLY3313 |
| J | FAD3351 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ALA8 | |
| A | ILE11 | |
| B | ALA1008 | |
| B | ILE1011 | |
| G | ALA2008 | |
| G | ILE2011 | |
| J | ALA3008 | |
| J | ILE3011 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17303072, ECO:0007744|PDB:2E4A, ECO:0007744|PDB:2E82 |
| Chain | Residue | Details |
| A | GLY9 | |
| B | GLY1009 | |
| G | GLY2009 | |
| J | GLY3009 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17088322, ECO:0000269|PubMed:23566269, ECO:0000269|PubMed:23631755, ECO:0007744|PDB:2DU8, ECO:0007744|PDB:3W4I, ECO:0007744|PDB:3W4J, ECO:0007744|PDB:3W4K, ECO:0007744|PDB:3ZNO, ECO:0007744|PDB:3ZNQ |
| Chain | Residue | Details |
| A | VAL10 | |
| B | VAL1010 | |
| G | VAL2010 | |
| J | VAL3010 |
| Chain | Residue | Details |
| A | ASP37 | |
| B | ASP1037 | |
| G | ASP2037 | |
| J | ASP3037 |
| Chain | Residue | Details |
| A | ARG38 | |
| B | VAL1164 | |
| B | GLY1312 | |
| B | THR1317 | |
| G | ARG2038 | |
| G | THR2045 | |
| G | LEU2051 | |
| G | VAL2164 | |
| G | GLY2312 | |
| G | THR2317 | |
| J | ARG3038 | |
| A | THR45 | |
| J | THR3045 | |
| J | LEU3051 | |
| J | VAL3164 | |
| J | GLY3312 | |
| J | THR3317 | |
| A | LEU51 | |
| A | VAL164 | |
| A | GLY312 | |
| A | THR317 | |
| B | ARG1038 | |
| B | THR1045 | |
| B | LEU1051 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18455394, ECO:0007744|PDB:3CUK |
| Chain | Residue | Details |
| A | THR43 | |
| B | THR1043 | |
| G | THR2043 | |
| J | THR3043 |
| Chain | Residue | Details |
| A | THR44 | |
| B | THR1044 | |
| G | THR2044 | |
| J | THR3044 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00371 |
| Chain | Residue | Details |
| A | ALA49 | |
| A | LYS163 | |
| B | ALA1049 | |
| B | LYS1163 | |
| G | ALA2049 | |
| G | LYS2163 | |
| J | ALA3049 | |
| J | LYS3163 |
| Chain | Residue | Details |
| A | GLY50 | |
| B | GLY1050 | |
| G | GLY2050 | |
| J | GLY3050 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17303072, ECO:0007744|PDB:2E82 |
| Chain | Residue | Details |
| A | GLN53 | |
| B | GLN1053 | |
| G | GLN2053 | |
| J | GLN3053 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0007744|PDB:3ZNQ |
| Chain | Residue | Details |
| A | THR182 | |
| B | THR1182 | |
| G | THR2182 | |
| J | THR3182 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:17303072, ECO:0007744|PDB:2E4A |
| Chain | Residue | Details |
| A | TYR224 | |
| B | TYR1224 | |
| G | TYR2224 | |
| J | TYR3224 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:17088322, ECO:0000305|PubMed:17303072, ECO:0000305|PubMed:18455394, ECO:0007744|PDB:2DU8, ECO:0007744|PDB:2E4A, ECO:0007744|PDB:3CUK |
| Chain | Residue | Details |
| A | TYR228 | |
| B | TYR1228 | |
| G | TYR2228 | |
| J | TYR3228 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17303072, ECO:0000269|PubMed:18455394, ECO:0000269|PubMed:23566269, ECO:0000269|PubMed:23631755, ECO:0007744|PDB:2E48, ECO:0007744|PDB:2E49, ECO:0007744|PDB:2E82, ECO:0007744|PDB:3CUK, ECO:0007744|PDB:3W4I, ECO:0007744|PDB:3W4J, ECO:0007744|PDB:3W4K, ECO:0007744|PDB:3ZNO |
| Chain | Residue | Details |
| A | ARG283 | |
| B | ARG1283 | |
| G | ARG2283 | |
| J | ARG3283 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17088322, ECO:0000269|PubMed:17303072, ECO:0000269|PubMed:23566269, ECO:0000269|PubMed:23631755, ECO:0000269|PubMed:25001371, ECO:0007744|PDB:2DU8, ECO:0007744|PDB:2E48, ECO:0007744|PDB:2E49, ECO:0007744|PDB:2E82, ECO:0007744|PDB:3W4I, ECO:0007744|PDB:3W4J, ECO:0007744|PDB:3W4K, ECO:0007744|PDB:3ZNO, ECO:0007744|PDB:3ZNP, ECO:0007744|PDB:3ZNQ, ECO:0007744|PDB:4QFD |
| Chain | Residue | Details |
| A | GLY313 | |
| B | GLY1313 | |
| G | GLY2313 | |
| J | GLY3313 |
| Chain | Residue | Details |
| A | GLY315 | |
| B | GLY1315 | |
| G | GLY2315 | |
| J | GLY3315 |
| Chain | Residue | Details |
| A | LEU316 | |
| B | LEU1316 | |
| G | LEU2316 | |
| J | LEU3316 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1c0k |
| Chain | Residue | Details |
| A | GLY313 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1c0k |
| Chain | Residue | Details |
| B | GLY1313 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1c0k |
| Chain | Residue | Details |
| G | GLY2313 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1c0k |
| Chain | Residue | Details |
| J | GLY3313 |
