2DTZ

Crystal Structure of multidrug binding protein QacR from Staphylococcus aureus cocrystallized with compound DB75

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0045892	biological_process	negative regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0045892	biological_process	negative regulation of DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0045892	biological_process	negative regulation of DNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 503

Chain	Residue
A	ASN2
A	LEU3
A	LYS4
A	ASN38
A	HIS42

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 504

Chain	Residue
A	LYS4
A	HIS42

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 506

Chain	Residue
E	GLN180
E	ARG76
E	TYR80

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 507

Chain	Residue
A	HIS128
A	LYS132

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 512

Chain	Residue
E	THR24
E	THR25
E	GLY26
E	LYS36

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 514

Chain	Residue
E	LYS36
E	TYR40
E	THR45
E	LYS46
E	GLU47

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 515

Chain	Residue
E	HIS128
E	LYS132

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 516

Chain	Residue
D	SER141
D	SER187

---

Functional Information from PROSITE/UniProt

site_id	PS01081
Number of Residues	31
Details	HTH_TETR_1 TetR-type HTH domain signature. GYnatTTgeIvklseSSkGnLYyHFkTKen.L

Chain	Residue	Details
B	GLY19-LEU49

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	57
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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