2DSC
Crystal structure of human ADP-ribose pyrophosphatase NUDT5 in complex with magnesium and ADP-ribose
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003723 | molecular_function | RNA binding |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005829 | cellular_component | cytosol |
A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
A | 0006338 | biological_process | chromatin remodeling |
A | 0006753 | biological_process | nucleoside phosphate metabolic process |
A | 0009117 | biological_process | nucleotide metabolic process |
A | 0009191 | biological_process | ribonucleoside diphosphate catabolic process |
A | 0016462 | molecular_function | pyrophosphatase activity |
A | 0016740 | molecular_function | transferase activity |
A | 0016779 | molecular_function | nucleotidyltransferase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0017110 | molecular_function | nucleoside diphosphate phosphatase activity |
A | 0019144 | molecular_function | ADP-sugar diphosphatase activity |
A | 0019303 | biological_process | D-ribose catabolic process |
A | 0019693 | biological_process | ribose phosphate metabolic process |
A | 0030515 | molecular_function | snoRNA binding |
A | 0042802 | molecular_function | identical protein binding |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0044715 | molecular_function | 8-oxo-dGDP phosphatase activity |
A | 0044716 | molecular_function | 8-oxo-GDP phosphatase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
A | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
A | 0070062 | cellular_component | extracellular exosome |
A | 0140933 | molecular_function | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity |
A | 1990966 | biological_process | ATP generation from poly-ADP-D-ribose |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003723 | molecular_function | RNA binding |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005829 | cellular_component | cytosol |
B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
B | 0006338 | biological_process | chromatin remodeling |
B | 0006753 | biological_process | nucleoside phosphate metabolic process |
B | 0009117 | biological_process | nucleotide metabolic process |
B | 0009191 | biological_process | ribonucleoside diphosphate catabolic process |
B | 0016462 | molecular_function | pyrophosphatase activity |
B | 0016740 | molecular_function | transferase activity |
B | 0016779 | molecular_function | nucleotidyltransferase activity |
B | 0016787 | molecular_function | hydrolase activity |
B | 0017110 | molecular_function | nucleoside diphosphate phosphatase activity |
B | 0019144 | molecular_function | ADP-sugar diphosphatase activity |
B | 0019303 | biological_process | D-ribose catabolic process |
B | 0019693 | biological_process | ribose phosphate metabolic process |
B | 0030515 | molecular_function | snoRNA binding |
B | 0042802 | molecular_function | identical protein binding |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0044715 | molecular_function | 8-oxo-dGDP phosphatase activity |
B | 0044716 | molecular_function | 8-oxo-GDP phosphatase activity |
B | 0046872 | molecular_function | metal ion binding |
B | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
B | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
B | 0070062 | cellular_component | extracellular exosome |
B | 0140933 | molecular_function | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity |
B | 1990966 | biological_process | ATP generation from poly-ADP-D-ribose |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 301 |
Chain | Residue |
A | APR402 |
B | ALA96 |
B | GLU112 |
B | GLU116 |
B | HOH418 |
B | HOH448 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 302 |
Chain | Residue |
A | HOH409 |
A | HOH433 |
B | APR401 |
A | ALA96 |
A | GLU116 |
A | GLU166 |
site_id | AC3 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE APR B 401 |
Chain | Residue |
A | TRP28 |
A | VAL29 |
A | ARG51 |
A | ARG84 |
A | ALA96 |
A | GLY97 |
A | LEU98 |
A | MET132 |
A | GLU166 |
A | ARG196 |
A | MG302 |
A | HOH451 |
A | HOH486 |
A | HOH487 |
B | TRP46 |
B | GLU47 |
B | ASP133 |
B | GLY135 |
B | LEU136 |
B | HOH472 |
B | HOH476 |
B | HOH480 |
B | HOH484 |
B | HOH485 |
B | HOH507 |
B | HOH529 |
site_id | AC4 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE APR A 402 |
Chain | Residue |
A | TRP46 |
A | GLU47 |
A | ASP133 |
A | GLY135 |
A | LEU136 |
A | HOH444 |
A | HOH461 |
B | TRP28 |
B | VAL29 |
B | ARG51 |
B | ARG84 |
B | ALA96 |
B | GLY97 |
B | LEU98 |
B | GLU166 |
B | MG301 |
B | HOH486 |
B | HOH504 |
B | HOH517 |
B | HOH547 |
Functional Information from PROSITE/UniProt
site_id | PS00893 |
Number of Residues | 22 |
Details | NUDIX_BOX Nudix box signature. GliddgEtpeaAAlRELeEEtG |
Chain | Residue | Details |
A | GLY97-GLY118 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: in other chain => ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:18462755, ECO:0000269|PubMed:21768126 |
Chain | Residue | Details |
B | TRP28 | |
B | ARG84 | |
A | TRP28 | |
A | ARG84 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:18462755, ECO:0000269|PubMed:21768126 |
Chain | Residue | Details |
B | TRP46 | |
B | ARG51 | |
B | ALA96 | |
B | GLU112 | |
B | GLU116 | |
B | GLU166 | |
A | TRP46 | |
A | ARG51 | |
A | ALA96 | |
A | GLU112 | |
A | GLU116 | |
A | GLU166 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: in other chain => ECO:0000269|PubMed:17052728 |
Chain | Residue | Details |
A | LEU98 | |
A | ASP133 | |
B | LEU98 | |
B | ASP133 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:22223895 |
Chain | Residue | Details |
A | MET1 | |
B | MET1 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER3 | |
B | SER3 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
Chain | Residue | Details |
A | SER10 | |
B | SER10 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:27257257 |
Chain | Residue | Details |
A | THR45 | |
B | THR45 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
Chain | Residue | Details |
A | TYR74 | |
B | TYR74 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS210 | |
B | LYS210 |
site_id | SWS_FT_FI10 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
B | LYS42 | |
A | LYS42 |