2DQ7

Crystal Structure of Fyn kinase domain complexed with staurosporine

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0004672	molecular_function	protein kinase activity
X	0004713	molecular_function	protein tyrosine kinase activity
X	0005524	molecular_function	ATP binding
X	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE STU X 902

Chain	Residue
X	LEU17
X	ALA134
X	LEU137
X	ASP148
X	ASN19
X	ALA37
X	LYS39
X	THR82
X	GLU83
X	TYR84
X	MET85
X	GLY88

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	23
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGNGQFGEVWmGtwngntk...........VAIK

Chain	Residue	Details
X	LEU17-LYS39

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLRSANILV

Chain	Residue	Details
X	TYR126-VAL138

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
X	ASP130

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
X	LEU17
X	LYS39

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:P39688

Chain	Residue	Details
X	PTR160

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by CSK => ECO:0000269|PubMed:1699196, ECO:0007744|PubMed:18691976

Chain	Residue	Details
X	TYR271

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
X	ALA134
X	ASP130

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
X	ASP130
X	ARG132

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site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
X	ASN135
X	ASP130
X	ARG132

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