2DOI

The X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcus protein PAM

Functional Information from PROSITE/UniProt

site_id	PS00021
Number of Residues	14
Details	KRINGLE_1 Kringle domain signature. YCRNpdndpqgpWC

Chain	Residue	Details
X	TYR132-CYS145
X	TYR214-CYS226

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
X	ARG117
X	ASP139
X	ARG153
A	ARG117
A	ASP139
A	ARG153

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site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Interacts with fibrin

Chain	Residue	Details
X	ARG115
X	ARG117
A	ARG115
A	ARG117

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:3356193, ECO:0000269|PubMed:9054441

Chain	Residue	Details
X	SER249
A	SER249

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:3356193

Chain	Residue	Details
X	GLU289
A	GLU289

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 425

Chain

Residue

Details

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site_id	MCSA2
Number of Residues
Details	M-CSA 425

Chain

Residue

Details

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