2DMM

The solution structure of the second thioredoxin domain of human Protein disulfide-isomerase A3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003756	molecular_function	protein disulfide isomerase activity

Functional Information from PROSITE/UniProt

site_id	PS00194
Number of Residues	19
Details	THIOREDOXIN_1 Thioredoxin family active site. LIeFYapWCGHCKnLepkY

Chain	Residue	Details
A	LEU49-TYR67

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:19119025, ECO:0000269|PubMed:35948544, ECO:0007744|PDB:3F8U, ECO:0007744|PDB:7QPD

Chain	Residue	Details
A	CYS57
A	CYS60

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Contributes to redox potential value => ECO:0000250

Chain	Residue	Details
A	GLY58
A	HIS59

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Lowers pKa of C-terminal Cys of second active site => ECO:0000250

Chain	Residue	Details
A	ARG122

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P27773

Chain	Residue	Details
A	LYS13

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1mek

Chain	Residue	Details
A	GLY58
A	CYS60
A	HIS59
A	CYS57

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1mek

Chain	Residue	Details
A	CYS60
A	CYS57

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