2DLD
D-LACTATE DEHYDROGENASE COMPLEXED WITH NADH AND OXAMATE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008720 | molecular_function | D-lactate dehydrogenase (NAD+) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0051287 | molecular_function | NAD binding |
| B | 0008720 | molecular_function | D-lactate dehydrogenase (NAD+) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE NAI A 401 |
| Chain | Residue |
| A | THR154 |
| A | ASN213 |
| A | CYS234 |
| A | SER235 |
| A | ARG236 |
| A | THR261 |
| A | HIS297 |
| A | ALA299 |
| A | PHE337 |
| A | OXM402 |
| A | GLY155 |
| A | HIS156 |
| A | ILE157 |
| A | ASP176 |
| A | ILE177 |
| A | HIS206 |
| A | VAL207 |
| A | PRO208 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE OXM A 402 |
| Chain | Residue |
| A | SER235 |
| A | ARG236 |
| A | HIS297 |
| A | NAI401 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE NAI B 401 |
| Chain | Residue |
| B | THR154 |
| B | GLY155 |
| B | HIS156 |
| B | ILE157 |
| B | ASP176 |
| B | ILE177 |
| B | HIS206 |
| B | VAL207 |
| B | PRO208 |
| B | ASN213 |
| B | CYS234 |
| B | SER235 |
| B | ARG236 |
| B | ASP260 |
| B | THR261 |
| B | HIS297 |
| B | ALA299 |
| B | OXM402 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE OXM B 402 |
| Chain | Residue |
| B | ARG236 |
| B | HIS297 |
| B | NAI401 |
Functional Information from PROSITE/UniProt
| site_id | PS00065 |
| Number of Residues | 28 |
| Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. VGVVGtGHIGqvfmrimegfgak.VIaYD |
| Chain | Residue | Details |
| A | VAL149-ASP176 |
| site_id | PS00670 |
| Number of Residues | 23 |
| Details | D_2_HYDROXYACID_DH_2 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. LYkqADVIsLHvPdvpaNvhMiN |
| Chain | Residue | Details |
| A | LEU196-ASN218 |
| site_id | PS00671 |
| Number of Residues | 17 |
| Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MKdGvVIVNcSRGrLVD |
| Chain | Residue | Details |
| A | MET225-ASP241 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"P26297","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P26297","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"OCT-1995","submissionDatabase":"PDB data bank","authors":["Bernard N.","Delcour J.","Alvarez A.","Cortes A.","Willis C.","Holbrook J.J."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"OCT-1995","submissionDatabase":"PDB data bank","authors":["Bernard N.","Delcour J.","Alvarez A.","Cortes A.","Willis C.","Holbrook J.J."]}}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1j49 |
| Chain | Residue | Details |
| A | ARG236 | |
| A | ASP209 | |
| A | GLU265 | |
| A | HIS297 | |
| A | ASP260 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1j49 |
| Chain | Residue | Details |
| B | ARG236 | |
| B | ASP209 | |
| B | GLU265 | |
| B | HIS297 | |
| B | ASP260 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1j49 |
| Chain | Residue | Details |
| A | GLU265 | |
| A | HIS297 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1j49 |
| Chain | Residue | Details |
| B | GLU265 | |
| B | HIS297 |
