2DKK

Structure/Function studies of Cytochrome P450 158A1 from Streptomyces Coelicolor A3(2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
A	0042440	biological_process	pigment metabolic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM A 430

Chain	Residue
A	ARG74
A	TYR321
A	ALA348
A	TYR349
A	HIS354
A	CYS356
A	THR357
A	LEU361
A	IMD431
A	HOH510
A	HOH517
A	LEU96
A	HOH645
A	ALA97
A	HIS104
A	PHE115
A	GLY245
A	ALA248
A	HIS290
A	ARG298

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IMD A 431

Chain	Residue
A	GLY245
A	ALA248
A	HEM430
A	HOH661
A	HOH705

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site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE IMD A 432

Chain	Residue
A	HIS88
A	LYS90
A	ARG92
A	LYS195
A	TYR199
A	HOH649
A	HOH671
A	HOH719

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:17614370, ECO:0007744|PDB:2NZ5

Chain	Residue	Details
A	ARG92
A	TYR199
A	HIS290

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000269|PubMed:17614370, ECO:0007744|PDB:2DKK, ECO:0007744|PDB:2NZ5, ECO:0007744|PDB:2NZA

Chain	Residue	Details
A	CYS356

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Involved in determining product regiospecificity => ECO:0000269|PubMed:22203090

Chain	Residue	Details
A	LYS90

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