2DGN

Mouse Muscle Adenylosuccinate Synthetase partially ligated complex with GTP, 2'-deoxy-IMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003924	molecular_function	GTPase activity
A	0004019	molecular_function	adenylosuccinate synthase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0006163	biological_process	purine nucleotide metabolic process
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006167	biological_process	AMP biosynthetic process
A	0006531	biological_process	aspartate metabolic process
A	0006541	biological_process	glutamine metabolic process
A	0014850	biological_process	response to muscle activity
A	0016020	cellular_component	membrane
A	0016874	molecular_function	ligase activity
A	0042594	biological_process	response to starvation
A	0042802	molecular_function	identical protein binding
A	0044208	biological_process	'de novo' AMP biosynthetic process
A	0044209	biological_process	AMP salvage
A	0046040	biological_process	IMP metabolic process
A	0046872	molecular_function	metal ion binding
A	0051015	molecular_function	actin filament binding
A	0071257	biological_process	cellular response to electrical stimulus
A	0071466	biological_process	cellular response to xenobiotic stimulus

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1454

Chain	Residue
A	ASP43
A	GLY70
A	HOH513
A	DOI1451
A	GDP1452

---

site_id	AC2
Number of Residues	26
Details	BINDING SITE FOR RESIDUE DOI A 1451

Chain	Residue
A	ASN68
A	ALA69
A	GLY70
A	HIS71
A	ILE160
A	GLY161
A	THR162
A	THR163
A	ARG177
A	ASN256
A	LEU260
A	VAL270
A	THR271
A	VAL305
A	GLY306
A	HOH509
A	HOH510
A	HOH532
A	HOH533
A	HOH546
A	GDP1452
A	MG1454
A	TRP41
A	GLY42
A	ASP43
A	LYS46

---

site_id	AC3
Number of Residues	21
Details	BINDING SITE FOR RESIDUE GDP A 1452

Chain	Residue
A	ASP43
A	GLU44
A	GLY45
A	LYS46
A	GLY47
A	LYS48
A	GLY70
A	HIS71
A	THR72
A	LYS363
A	ASP365
A	ILE366
A	GLY445
A	VAL446
A	GLY447
A	LYS448
A	HOH512
A	HOH513
A	HOH514
A	DOI1451
A	MG1454

---

Functional Information from PROSITE/UniProt

site_id	PS00513
Number of Residues	12
Details	ADENYLOSUCCIN_SYN_2 Adenylosuccinate synthetase active site. GIGPtYssKaaR

Chain	Residue	Details
A	GLY166-ARG177

---

site_id	PS01266
Number of Residues	8
Details	ADENYLOSUCCIN_SYN_1 Adenylosuccinate synthetase GTP-binding site. QWGDEGKG

Chain	Residue	Details
A	GLN40-GLY47

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_03126","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_03126","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03126","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12004071","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"description":"in other chain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_03126","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12004071","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---