2DFT
Structure of shikimate kinase from Mycobacterium tuberculosis complexed with ADP and Mg at 2.8 angstrons of resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004765 | molecular_function | shikimate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0019632 | biological_process | shikimate metabolic process |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004765 | molecular_function | shikimate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0019632 | biological_process | shikimate metabolic process |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004765 | molecular_function | shikimate kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009423 | biological_process | chorismate biosynthetic process |
| C | 0019632 | biological_process | shikimate metabolic process |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004765 | molecular_function | shikimate kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009423 | biological_process | chorismate biosynthetic process |
| D | 0019632 | biological_process | shikimate metabolic process |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 190 |
| Chain | Residue |
| A | SER16 |
| A | ADP180 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 193 |
| Chain | Residue |
| A | PRO11 |
| A | LYS15 |
| A | GLY80 |
| A | ADP180 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 196 |
| Chain | Residue |
| B | HOH251 |
| B | HOH254 |
| B | HOH312 |
| B | SER16 |
| B | ASP34 |
| B | ADP181 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 199 |
| Chain | Residue |
| B | PRO11 |
| B | LYS15 |
| B | GLY80 |
| B | HOH251 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG C 202 |
| Chain | Residue |
| A | ASP47 |
| C | SER16 |
| C | ADP182 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG D 208 |
| Chain | Residue |
| D | SER16 |
| D | ASP32 |
| D | ADP183 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL D 211 |
| Chain | Residue |
| D | PRO11 |
| D | LYS15 |
| D | GLY80 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP A 180 |
| Chain | Residue |
| A | LEU10 |
| A | PRO11 |
| A | GLY12 |
| A | SER13 |
| A | GLY14 |
| A | LYS15 |
| A | SER16 |
| A | THR17 |
| A | ARG110 |
| A | ARG153 |
| A | MG190 |
| A | CL193 |
| A | HOH255 |
| A | HOH301 |
| A | HOH449 |
| B | ADP181 |
| site_id | AC9 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP B 181 |
| Chain | Residue |
| A | ADP180 |
| B | LEU10 |
| B | GLY12 |
| B | SER13 |
| B | GLY14 |
| B | LYS15 |
| B | SER16 |
| B | THR17 |
| B | ARG110 |
| B | ARG117 |
| B | ARG153 |
| B | ASN154 |
| B | PRO155 |
| B | MG196 |
| B | HOH225 |
| B | HOH312 |
| site_id | BC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ADP C 182 |
| Chain | Residue |
| C | LEU10 |
| C | PRO11 |
| C | GLY12 |
| C | SER13 |
| C | GLY14 |
| C | LYS15 |
| C | SER16 |
| C | THR17 |
| C | ARG110 |
| C | THR150 |
| C | ARG153 |
| C | PRO155 |
| C | MG202 |
| C | HOH220 |
| C | HOH412 |
| C | HOH445 |
| D | ADP183 |
| site_id | BC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP D 183 |
| Chain | Residue |
| C | PRO155 |
| C | ADP182 |
| C | HOH412 |
| D | PRO11 |
| D | GLY12 |
| D | SER13 |
| D | GLY14 |
| D | LYS15 |
| D | SER16 |
| D | THR17 |
| D | ARG110 |
| D | ARG117 |
| D | ARG153 |
| D | MG208 |
| D | HOH241 |
| D | HOH407 |
Functional Information from PROSITE/UniProt
| site_id | PS01128 |
| Number of Residues | 26 |
| Details | SHIKIMATE_KINASE Shikimate kinase signature. RriEedvVraaladhdg...VLSlGGGaV |
| Chain | Residue | Details |
| A | ARG58-VAL83 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 46 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Region: {"description":"LID domain"} |
| Chain | Residue | Details |
