Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2DFS

3-D structure of Myosin-V inhibited state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003774	molecular_function	cytoskeletal motor activity
A	0005524	molecular_function	ATP binding
A	0016459	cellular_component	myosin complex
B	0000086	biological_process	G2/M transition of mitotic cell cycle
B	0000922	cellular_component	spindle pole
B	0002027	biological_process	regulation of heart rate
B	0005509	molecular_function	calcium ion binding
B	0005513	biological_process	detection of calcium ion
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005819	cellular_component	spindle
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005876	cellular_component	spindle microtubule
B	0005929	cellular_component	cilium
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0008179	molecular_function	adenylate cyclase binding
B	0010856	molecular_function	adenylate cyclase activator activity
B	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0016240	biological_process	autophagosome membrane docking
B	0019855	molecular_function	calcium channel inhibitor activity
B	0019901	molecular_function	protein kinase binding
B	0019904	molecular_function	protein domain specific binding
B	0030017	cellular_component	sarcomere
B	0030234	molecular_function	enzyme regulator activity
B	0030235	molecular_function	nitric-oxide synthase regulator activity
B	0030426	cellular_component	growth cone
B	0030672	cellular_component	synaptic vesicle membrane
B	0031432	molecular_function	titin binding
B	0031514	cellular_component	motile cilium
B	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
B	0031966	cellular_component	mitochondrial membrane
B	0032465	biological_process	regulation of cytokinesis
B	0032991	cellular_component	protein-containing complex
B	0034704	cellular_component	calcium channel complex
B	0035307	biological_process	positive regulation of protein dephosphorylation
B	0035458	biological_process	cellular response to interferon-beta
B	0042995	cellular_component	cell projection
B	0043209	cellular_component	myelin sheath
B	0043539	molecular_function	protein serine/threonine kinase activator activity
B	0043548	molecular_function	phosphatidylinositol 3-kinase binding
B	0044325	molecular_function	transmembrane transporter binding
B	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
B	0046872	molecular_function	metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0050998	molecular_function	nitric-oxide synthase binding
B	0051592	biological_process	response to calcium ion
B	0055117	biological_process	regulation of cardiac muscle contraction
B	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
B	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
B	0071346	biological_process	cellular response to type II interferon
B	0072542	molecular_function	protein phosphatase activator activity
B	0097225	cellular_component	sperm midpiece
B	0098901	biological_process	regulation of cardiac muscle cell action potential
B	0140056	biological_process	organelle localization by membrane tethering
B	1902494	cellular_component	catalytic complex
B	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
C	0000086	biological_process	G2/M transition of mitotic cell cycle
C	0000922	cellular_component	spindle pole
C	0002027	biological_process	regulation of heart rate
C	0005509	molecular_function	calcium ion binding
C	0005513	biological_process	detection of calcium ion
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005876	cellular_component	spindle microtubule
C	0005929	cellular_component	cilium
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0008179	molecular_function	adenylate cyclase binding
C	0010856	molecular_function	adenylate cyclase activator activity
C	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C	0016240	biological_process	autophagosome membrane docking
C	0019855	molecular_function	calcium channel inhibitor activity
C	0019901	molecular_function	protein kinase binding
C	0019904	molecular_function	protein domain specific binding
C	0030017	cellular_component	sarcomere
C	0030234	molecular_function	enzyme regulator activity
C	0030235	molecular_function	nitric-oxide synthase regulator activity
C	0030426	cellular_component	growth cone
C	0030672	cellular_component	synaptic vesicle membrane
C	0031432	molecular_function	titin binding
C	0031514	cellular_component	motile cilium
C	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
C	0031966	cellular_component	mitochondrial membrane
C	0032465	biological_process	regulation of cytokinesis
C	0032991	cellular_component	protein-containing complex
C	0034704	cellular_component	calcium channel complex
C	0035307	biological_process	positive regulation of protein dephosphorylation
C	0035458	biological_process	cellular response to interferon-beta
C	0042995	cellular_component	cell projection
C	0043209	cellular_component	myelin sheath
C	0043539	molecular_function	protein serine/threonine kinase activator activity
C	0043548	molecular_function	phosphatidylinositol 3-kinase binding
C	0044325	molecular_function	transmembrane transporter binding
C	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
C	0046872	molecular_function	metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0050998	molecular_function	nitric-oxide synthase binding
C	0051592	biological_process	response to calcium ion
C	0055117	biological_process	regulation of cardiac muscle contraction
C	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
C	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
C	0071346	biological_process	cellular response to type II interferon
C	0072542	molecular_function	protein phosphatase activator activity
C	0097225	cellular_component	sperm midpiece
C	0098901	biological_process	regulation of cardiac muscle cell action potential
C	0140056	biological_process	organelle localization by membrane tethering
C	1902494	cellular_component	catalytic complex
C	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
D	0000086	biological_process	G2/M transition of mitotic cell cycle
D	0000922	cellular_component	spindle pole
D	0002027	biological_process	regulation of heart rate
D	0005509	molecular_function	calcium ion binding
D	0005513	biological_process	detection of calcium ion
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005819	cellular_component	spindle
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005876	cellular_component	spindle microtubule
D	0005929	cellular_component	cilium
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0008179	molecular_function	adenylate cyclase binding
D	0010856	molecular_function	adenylate cyclase activator activity
D	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D	0016240	biological_process	autophagosome membrane docking
D	0019855	molecular_function	calcium channel inhibitor activity
D	0019901	molecular_function	protein kinase binding
D	0019904	molecular_function	protein domain specific binding
D	0030017	cellular_component	sarcomere
D	0030234	molecular_function	enzyme regulator activity
D	0030235	molecular_function	nitric-oxide synthase regulator activity
D	0030426	cellular_component	growth cone
D	0030672	cellular_component	synaptic vesicle membrane
D	0031432	molecular_function	titin binding
D	0031514	cellular_component	motile cilium
D	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
D	0031966	cellular_component	mitochondrial membrane
D	0032465	biological_process	regulation of cytokinesis
D	0032991	cellular_component	protein-containing complex
D	0034704	cellular_component	calcium channel complex
D	0035307	biological_process	positive regulation of protein dephosphorylation
D	0035458	biological_process	cellular response to interferon-beta
D	0042995	cellular_component	cell projection
D	0043209	cellular_component	myelin sheath
D	0043539	molecular_function	protein serine/threonine kinase activator activity
D	0043548	molecular_function	phosphatidylinositol 3-kinase binding
D	0044325	molecular_function	transmembrane transporter binding
D	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
D	0046872	molecular_function	metal ion binding
D	0048306	molecular_function	calcium-dependent protein binding
D	0050998	molecular_function	nitric-oxide synthase binding
D	0051592	biological_process	response to calcium ion
D	0055117	biological_process	regulation of cardiac muscle contraction
D	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
D	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
D	0071346	biological_process	cellular response to type II interferon
D	0072542	molecular_function	protein phosphatase activator activity
D	0097225	cellular_component	sperm midpiece
D	0098901	biological_process	regulation of cardiac muscle cell action potential
D	0140056	biological_process	organelle localization by membrane tethering
D	1902494	cellular_component	catalytic complex
D	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
E	0000086	biological_process	G2/M transition of mitotic cell cycle
E	0000922	cellular_component	spindle pole
E	0002027	biological_process	regulation of heart rate
E	0005509	molecular_function	calcium ion binding
E	0005513	biological_process	detection of calcium ion
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005876	cellular_component	spindle microtubule
E	0005929	cellular_component	cilium
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0008179	molecular_function	adenylate cyclase binding
E	0010856	molecular_function	adenylate cyclase activator activity
E	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0016240	biological_process	autophagosome membrane docking
E	0019855	molecular_function	calcium channel inhibitor activity
E	0019901	molecular_function	protein kinase binding
E	0019904	molecular_function	protein domain specific binding
E	0030017	cellular_component	sarcomere
E	0030234	molecular_function	enzyme regulator activity
E	0030235	molecular_function	nitric-oxide synthase regulator activity
E	0030426	cellular_component	growth cone
E	0030672	cellular_component	synaptic vesicle membrane
E	0031432	molecular_function	titin binding
E	0031514	cellular_component	motile cilium
E	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
E	0031966	cellular_component	mitochondrial membrane
E	0032465	biological_process	regulation of cytokinesis
E	0032991	cellular_component	protein-containing complex
E	0034704	cellular_component	calcium channel complex
E	0035307	biological_process	positive regulation of protein dephosphorylation
E	0035458	biological_process	cellular response to interferon-beta
E	0042995	cellular_component	cell projection
E	0043209	cellular_component	myelin sheath
E	0043539	molecular_function	protein serine/threonine kinase activator activity
E	0043548	molecular_function	phosphatidylinositol 3-kinase binding
E	0044325	molecular_function	transmembrane transporter binding
E	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
E	0046872	molecular_function	metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0050998	molecular_function	nitric-oxide synthase binding
E	0051592	biological_process	response to calcium ion
E	0055117	biological_process	regulation of cardiac muscle contraction
E	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
E	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
E	0071346	biological_process	cellular response to type II interferon
E	0072542	molecular_function	protein phosphatase activator activity
E	0097225	cellular_component	sperm midpiece
E	0098901	biological_process	regulation of cardiac muscle cell action potential
E	0140056	biological_process	organelle localization by membrane tethering
E	1902494	cellular_component	catalytic complex
E	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
F	0000086	biological_process	G2/M transition of mitotic cell cycle
F	0000922	cellular_component	spindle pole
F	0002027	biological_process	regulation of heart rate
F	0005509	molecular_function	calcium ion binding
F	0005513	biological_process	detection of calcium ion
F	0005515	molecular_function	protein binding
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005876	cellular_component	spindle microtubule
F	0005929	cellular_component	cilium
F	0008076	cellular_component	voltage-gated potassium channel complex
F	0008179	molecular_function	adenylate cyclase binding
F	0010856	molecular_function	adenylate cyclase activator activity
F	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0016240	biological_process	autophagosome membrane docking
F	0019855	molecular_function	calcium channel inhibitor activity
F	0019901	molecular_function	protein kinase binding
F	0019904	molecular_function	protein domain specific binding
F	0030017	cellular_component	sarcomere
F	0030234	molecular_function	enzyme regulator activity
F	0030235	molecular_function	nitric-oxide synthase regulator activity
F	0030426	cellular_component	growth cone
F	0030672	cellular_component	synaptic vesicle membrane
F	0031432	molecular_function	titin binding
F	0031514	cellular_component	motile cilium
F	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
F	0031966	cellular_component	mitochondrial membrane
F	0032465	biological_process	regulation of cytokinesis
F	0032991	cellular_component	protein-containing complex
F	0034704	cellular_component	calcium channel complex
F	0035307	biological_process	positive regulation of protein dephosphorylation
F	0035458	biological_process	cellular response to interferon-beta
F	0042995	cellular_component	cell projection
F	0043209	cellular_component	myelin sheath
F	0043539	molecular_function	protein serine/threonine kinase activator activity
F	0043548	molecular_function	phosphatidylinositol 3-kinase binding
F	0044325	molecular_function	transmembrane transporter binding
F	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
F	0046872	molecular_function	metal ion binding
F	0048306	molecular_function	calcium-dependent protein binding
F	0050998	molecular_function	nitric-oxide synthase binding
F	0051592	biological_process	response to calcium ion
F	0055117	biological_process	regulation of cardiac muscle contraction
F	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
F	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
F	0071346	biological_process	cellular response to type II interferon
F	0072542	molecular_function	protein phosphatase activator activity
F	0097225	cellular_component	sperm midpiece
F	0098901	biological_process	regulation of cardiac muscle cell action potential
F	0140056	biological_process	organelle localization by membrane tethering
F	1902494	cellular_component	catalytic complex
F	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
G	0000086	biological_process	G2/M transition of mitotic cell cycle
G	0000922	cellular_component	spindle pole
G	0002027	biological_process	regulation of heart rate
G	0005509	molecular_function	calcium ion binding
G	0005513	biological_process	detection of calcium ion
G	0005515	molecular_function	protein binding
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005813	cellular_component	centrosome
G	0005819	cellular_component	spindle
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005876	cellular_component	spindle microtubule
G	0005929	cellular_component	cilium
G	0008076	cellular_component	voltage-gated potassium channel complex
G	0008179	molecular_function	adenylate cyclase binding
G	0010856	molecular_function	adenylate cyclase activator activity
G	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G	0016240	biological_process	autophagosome membrane docking
G	0019855	molecular_function	calcium channel inhibitor activity
G	0019901	molecular_function	protein kinase binding
G	0019904	molecular_function	protein domain specific binding
G	0030017	cellular_component	sarcomere
G	0030234	molecular_function	enzyme regulator activity
G	0030235	molecular_function	nitric-oxide synthase regulator activity
G	0030426	cellular_component	growth cone
G	0030672	cellular_component	synaptic vesicle membrane
G	0031432	molecular_function	titin binding
G	0031514	cellular_component	motile cilium
G	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
G	0031966	cellular_component	mitochondrial membrane
G	0032465	biological_process	regulation of cytokinesis
G	0032991	cellular_component	protein-containing complex
G	0034704	cellular_component	calcium channel complex
G	0035307	biological_process	positive regulation of protein dephosphorylation
G	0035458	biological_process	cellular response to interferon-beta
G	0042995	cellular_component	cell projection
G	0043209	cellular_component	myelin sheath
G	0043539	molecular_function	protein serine/threonine kinase activator activity
G	0043548	molecular_function	phosphatidylinositol 3-kinase binding
G	0044325	molecular_function	transmembrane transporter binding
G	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
G	0046872	molecular_function	metal ion binding
G	0048306	molecular_function	calcium-dependent protein binding
G	0050998	molecular_function	nitric-oxide synthase binding
G	0051592	biological_process	response to calcium ion
G	0055117	biological_process	regulation of cardiac muscle contraction
G	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
G	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
G	0071346	biological_process	cellular response to type II interferon
G	0072542	molecular_function	protein phosphatase activator activity
G	0097225	cellular_component	sperm midpiece
G	0098901	biological_process	regulation of cardiac muscle cell action potential
G	0140056	biological_process	organelle localization by membrane tethering
G	1902494	cellular_component	catalytic complex
G	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
M	0003774	molecular_function	cytoskeletal motor activity
M	0005524	molecular_function	ATP binding
M	0016459	cellular_component	myosin complex
N	0000086	biological_process	G2/M transition of mitotic cell cycle
N	0000922	cellular_component	spindle pole
N	0002027	biological_process	regulation of heart rate
N	0005509	molecular_function	calcium ion binding
N	0005513	biological_process	detection of calcium ion
N	0005515	molecular_function	protein binding
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005813	cellular_component	centrosome
N	0005819	cellular_component	spindle
N	0005829	cellular_component	cytosol
N	0005856	cellular_component	cytoskeleton
N	0005876	cellular_component	spindle microtubule
N	0005929	cellular_component	cilium
N	0008076	cellular_component	voltage-gated potassium channel complex
N	0008179	molecular_function	adenylate cyclase binding
N	0010856	molecular_function	adenylate cyclase activator activity
N	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
N	0016240	biological_process	autophagosome membrane docking
N	0019855	molecular_function	calcium channel inhibitor activity
N	0019901	molecular_function	protein kinase binding
N	0019904	molecular_function	protein domain specific binding
N	0030017	cellular_component	sarcomere
N	0030234	molecular_function	enzyme regulator activity
N	0030235	molecular_function	nitric-oxide synthase regulator activity
N	0030426	cellular_component	growth cone
N	0030672	cellular_component	synaptic vesicle membrane
N	0031432	molecular_function	titin binding
N	0031514	cellular_component	motile cilium
N	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
N	0031966	cellular_component	mitochondrial membrane
N	0032465	biological_process	regulation of cytokinesis
N	0032991	cellular_component	protein-containing complex
N	0034704	cellular_component	calcium channel complex
N	0035307	biological_process	positive regulation of protein dephosphorylation
N	0035458	biological_process	cellular response to interferon-beta
N	0042995	cellular_component	cell projection
N	0043209	cellular_component	myelin sheath
N	0043539	molecular_function	protein serine/threonine kinase activator activity
N	0043548	molecular_function	phosphatidylinositol 3-kinase binding
N	0044325	molecular_function	transmembrane transporter binding
N	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
N	0046872	molecular_function	metal ion binding
N	0048306	molecular_function	calcium-dependent protein binding
N	0050998	molecular_function	nitric-oxide synthase binding
N	0051592	biological_process	response to calcium ion
N	0055117	biological_process	regulation of cardiac muscle contraction
N	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
N	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
N	0071346	biological_process	cellular response to type II interferon
N	0072542	molecular_function	protein phosphatase activator activity
N	0097225	cellular_component	sperm midpiece
N	0098901	biological_process	regulation of cardiac muscle cell action potential
N	0140056	biological_process	organelle localization by membrane tethering
N	1902494	cellular_component	catalytic complex
N	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
O	0000086	biological_process	G2/M transition of mitotic cell cycle
O	0000922	cellular_component	spindle pole
O	0002027	biological_process	regulation of heart rate
O	0005509	molecular_function	calcium ion binding
O	0005513	biological_process	detection of calcium ion
O	0005515	molecular_function	protein binding
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005813	cellular_component	centrosome
O	0005819	cellular_component	spindle
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0005876	cellular_component	spindle microtubule
O	0005929	cellular_component	cilium
O	0008076	cellular_component	voltage-gated potassium channel complex
O	0008179	molecular_function	adenylate cyclase binding
O	0010856	molecular_function	adenylate cyclase activator activity
O	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
O	0016240	biological_process	autophagosome membrane docking
O	0019855	molecular_function	calcium channel inhibitor activity
O	0019901	molecular_function	protein kinase binding
O	0019904	molecular_function	protein domain specific binding
O	0030017	cellular_component	sarcomere
O	0030234	molecular_function	enzyme regulator activity
O	0030235	molecular_function	nitric-oxide synthase regulator activity
O	0030426	cellular_component	growth cone
O	0030672	cellular_component	synaptic vesicle membrane
O	0031432	molecular_function	titin binding
O	0031514	cellular_component	motile cilium
O	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
O	0031966	cellular_component	mitochondrial membrane
O	0032465	biological_process	regulation of cytokinesis
O	0032991	cellular_component	protein-containing complex
O	0034704	cellular_component	calcium channel complex
O	0035307	biological_process	positive regulation of protein dephosphorylation
O	0035458	biological_process	cellular response to interferon-beta
O	0042995	cellular_component	cell projection
O	0043209	cellular_component	myelin sheath
O	0043539	molecular_function	protein serine/threonine kinase activator activity
O	0043548	molecular_function	phosphatidylinositol 3-kinase binding
O	0044325	molecular_function	transmembrane transporter binding
O	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
O	0046872	molecular_function	metal ion binding
O	0048306	molecular_function	calcium-dependent protein binding
O	0050998	molecular_function	nitric-oxide synthase binding
O	0051592	biological_process	response to calcium ion
O	0055117	biological_process	regulation of cardiac muscle contraction
O	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
O	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
O	0071346	biological_process	cellular response to type II interferon
O	0072542	molecular_function	protein phosphatase activator activity
O	0097225	cellular_component	sperm midpiece
O	0098901	biological_process	regulation of cardiac muscle cell action potential
O	0140056	biological_process	organelle localization by membrane tethering
O	1902494	cellular_component	catalytic complex
O	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
P	0000086	biological_process	G2/M transition of mitotic cell cycle
P	0000922	cellular_component	spindle pole
P	0002027	biological_process	regulation of heart rate
P	0005509	molecular_function	calcium ion binding
P	0005513	biological_process	detection of calcium ion
P	0005515	molecular_function	protein binding
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005813	cellular_component	centrosome
P	0005819	cellular_component	spindle
P	0005829	cellular_component	cytosol
P	0005856	cellular_component	cytoskeleton
P	0005876	cellular_component	spindle microtubule
P	0005929	cellular_component	cilium
P	0008076	cellular_component	voltage-gated potassium channel complex
P	0008179	molecular_function	adenylate cyclase binding
P	0010856	molecular_function	adenylate cyclase activator activity
P	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
P	0016240	biological_process	autophagosome membrane docking
P	0019855	molecular_function	calcium channel inhibitor activity
P	0019901	molecular_function	protein kinase binding
P	0019904	molecular_function	protein domain specific binding
P	0030017	cellular_component	sarcomere
P	0030234	molecular_function	enzyme regulator activity
P	0030235	molecular_function	nitric-oxide synthase regulator activity
P	0030426	cellular_component	growth cone
P	0030672	cellular_component	synaptic vesicle membrane
P	0031432	molecular_function	titin binding
P	0031514	cellular_component	motile cilium
P	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
P	0031966	cellular_component	mitochondrial membrane
P	0032465	biological_process	regulation of cytokinesis
P	0032991	cellular_component	protein-containing complex
P	0034704	cellular_component	calcium channel complex
P	0035307	biological_process	positive regulation of protein dephosphorylation
P	0035458	biological_process	cellular response to interferon-beta
P	0042995	cellular_component	cell projection
P	0043209	cellular_component	myelin sheath
P	0043539	molecular_function	protein serine/threonine kinase activator activity
P	0043548	molecular_function	phosphatidylinositol 3-kinase binding
P	0044325	molecular_function	transmembrane transporter binding
P	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
P	0046872	molecular_function	metal ion binding
P	0048306	molecular_function	calcium-dependent protein binding
P	0050998	molecular_function	nitric-oxide synthase binding
P	0051592	biological_process	response to calcium ion
P	0055117	biological_process	regulation of cardiac muscle contraction
P	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
P	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
P	0071346	biological_process	cellular response to type II interferon
P	0072542	molecular_function	protein phosphatase activator activity
P	0097225	cellular_component	sperm midpiece
P	0098901	biological_process	regulation of cardiac muscle cell action potential
P	0140056	biological_process	organelle localization by membrane tethering
P	1902494	cellular_component	catalytic complex
P	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
Q	0000086	biological_process	G2/M transition of mitotic cell cycle
Q	0000922	cellular_component	spindle pole
Q	0002027	biological_process	regulation of heart rate
Q	0005509	molecular_function	calcium ion binding
Q	0005513	biological_process	detection of calcium ion
Q	0005515	molecular_function	protein binding
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005813	cellular_component	centrosome
Q	0005819	cellular_component	spindle
Q	0005829	cellular_component	cytosol
Q	0005856	cellular_component	cytoskeleton
Q	0005876	cellular_component	spindle microtubule
Q	0005929	cellular_component	cilium
Q	0008076	cellular_component	voltage-gated potassium channel complex
Q	0008179	molecular_function	adenylate cyclase binding
Q	0010856	molecular_function	adenylate cyclase activator activity
Q	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Q	0016240	biological_process	autophagosome membrane docking
Q	0019855	molecular_function	calcium channel inhibitor activity
Q	0019901	molecular_function	protein kinase binding
Q	0019904	molecular_function	protein domain specific binding
Q	0030017	cellular_component	sarcomere
Q	0030234	molecular_function	enzyme regulator activity
Q	0030235	molecular_function	nitric-oxide synthase regulator activity
Q	0030426	cellular_component	growth cone
Q	0030672	cellular_component	synaptic vesicle membrane
Q	0031432	molecular_function	titin binding
Q	0031514	cellular_component	motile cilium
Q	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
Q	0031966	cellular_component	mitochondrial membrane
Q	0032465	biological_process	regulation of cytokinesis
Q	0032991	cellular_component	protein-containing complex
Q	0034704	cellular_component	calcium channel complex
Q	0035307	biological_process	positive regulation of protein dephosphorylation
Q	0035458	biological_process	cellular response to interferon-beta
Q	0042995	cellular_component	cell projection
Q	0043209	cellular_component	myelin sheath
Q	0043539	molecular_function	protein serine/threonine kinase activator activity
Q	0043548	molecular_function	phosphatidylinositol 3-kinase binding
Q	0044325	molecular_function	transmembrane transporter binding
Q	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
Q	0046872	molecular_function	metal ion binding
Q	0048306	molecular_function	calcium-dependent protein binding
Q	0050998	molecular_function	nitric-oxide synthase binding
Q	0051592	biological_process	response to calcium ion
Q	0055117	biological_process	regulation of cardiac muscle contraction
Q	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
Q	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
Q	0071346	biological_process	cellular response to type II interferon
Q	0072542	molecular_function	protein phosphatase activator activity
Q	0097225	cellular_component	sperm midpiece
Q	0098901	biological_process	regulation of cardiac muscle cell action potential
Q	0140056	biological_process	organelle localization by membrane tethering
Q	1902494	cellular_component	catalytic complex
Q	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
R	0000086	biological_process	G2/M transition of mitotic cell cycle
R	0000922	cellular_component	spindle pole
R	0002027	biological_process	regulation of heart rate
R	0005509	molecular_function	calcium ion binding
R	0005513	biological_process	detection of calcium ion
R	0005515	molecular_function	protein binding
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005813	cellular_component	centrosome
R	0005819	cellular_component	spindle
R	0005829	cellular_component	cytosol
R	0005856	cellular_component	cytoskeleton
R	0005876	cellular_component	spindle microtubule
R	0005929	cellular_component	cilium
R	0008076	cellular_component	voltage-gated potassium channel complex
R	0008179	molecular_function	adenylate cyclase binding
R	0010856	molecular_function	adenylate cyclase activator activity
R	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
R	0016240	biological_process	autophagosome membrane docking
R	0019855	molecular_function	calcium channel inhibitor activity
R	0019901	molecular_function	protein kinase binding
R	0019904	molecular_function	protein domain specific binding
R	0030017	cellular_component	sarcomere
R	0030234	molecular_function	enzyme regulator activity
R	0030235	molecular_function	nitric-oxide synthase regulator activity
R	0030426	cellular_component	growth cone
R	0030672	cellular_component	synaptic vesicle membrane
R	0031432	molecular_function	titin binding
R	0031514	cellular_component	motile cilium
R	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
R	0031966	cellular_component	mitochondrial membrane
R	0032465	biological_process	regulation of cytokinesis
R	0032991	cellular_component	protein-containing complex
R	0034704	cellular_component	calcium channel complex
R	0035307	biological_process	positive regulation of protein dephosphorylation
R	0035458	biological_process	cellular response to interferon-beta
R	0042995	cellular_component	cell projection
R	0043209	cellular_component	myelin sheath
R	0043539	molecular_function	protein serine/threonine kinase activator activity
R	0043548	molecular_function	phosphatidylinositol 3-kinase binding
R	0044325	molecular_function	transmembrane transporter binding
R	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
R	0046872	molecular_function	metal ion binding
R	0048306	molecular_function	calcium-dependent protein binding
R	0050998	molecular_function	nitric-oxide synthase binding
R	0051592	biological_process	response to calcium ion
R	0055117	biological_process	regulation of cardiac muscle contraction
R	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
R	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
R	0071346	biological_process	cellular response to type II interferon
R	0072542	molecular_function	protein phosphatase activator activity
R	0097225	cellular_component	sperm midpiece
R	0098901	biological_process	regulation of cardiac muscle cell action potential
R	0140056	biological_process	organelle localization by membrane tethering
R	1902494	cellular_component	catalytic complex
R	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
S	0000086	biological_process	G2/M transition of mitotic cell cycle
S	0000922	cellular_component	spindle pole
S	0002027	biological_process	regulation of heart rate
S	0005509	molecular_function	calcium ion binding
S	0005513	biological_process	detection of calcium ion
S	0005515	molecular_function	protein binding
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005813	cellular_component	centrosome
S	0005819	cellular_component	spindle
S	0005829	cellular_component	cytosol
S	0005856	cellular_component	cytoskeleton
S	0005876	cellular_component	spindle microtubule
S	0005929	cellular_component	cilium
S	0008076	cellular_component	voltage-gated potassium channel complex
S	0008179	molecular_function	adenylate cyclase binding
S	0010856	molecular_function	adenylate cyclase activator activity
S	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
S	0016240	biological_process	autophagosome membrane docking
S	0019855	molecular_function	calcium channel inhibitor activity
S	0019901	molecular_function	protein kinase binding
S	0019904	molecular_function	protein domain specific binding
S	0030017	cellular_component	sarcomere
S	0030234	molecular_function	enzyme regulator activity
S	0030235	molecular_function	nitric-oxide synthase regulator activity
S	0030426	cellular_component	growth cone
S	0030672	cellular_component	synaptic vesicle membrane
S	0031432	molecular_function	titin binding
S	0031514	cellular_component	motile cilium
S	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
S	0031966	cellular_component	mitochondrial membrane
S	0032465	biological_process	regulation of cytokinesis
S	0032991	cellular_component	protein-containing complex
S	0034704	cellular_component	calcium channel complex
S	0035307	biological_process	positive regulation of protein dephosphorylation
S	0035458	biological_process	cellular response to interferon-beta
S	0042995	cellular_component	cell projection
S	0043209	cellular_component	myelin sheath
S	0043539	molecular_function	protein serine/threonine kinase activator activity
S	0043548	molecular_function	phosphatidylinositol 3-kinase binding
S	0044325	molecular_function	transmembrane transporter binding
S	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
S	0046872	molecular_function	metal ion binding
S	0048306	molecular_function	calcium-dependent protein binding
S	0050998	molecular_function	nitric-oxide synthase binding
S	0051592	biological_process	response to calcium ion
S	0055117	biological_process	regulation of cardiac muscle contraction
S	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
S	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
S	0071346	biological_process	cellular response to type II interferon
S	0072542	molecular_function	protein phosphatase activator activity
S	0097225	cellular_component	sperm midpiece
S	0098901	biological_process	regulation of cardiac muscle cell action potential
S	0140056	biological_process	organelle localization by membrane tethering
S	1902494	cellular_component	catalytic complex
S	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
B	ASP20-LEU32
B	ASP56-PHE68
B	ASP93-LEU105
B	ASP129-PHE141

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00448, ECO:0007744\|PDB:4HEX, ECO:0007744\|PDB:4ZLK

Chain	Residue	Details
B	LYS21
B	PHE68
F	PHE141
G	LYS21
G	GLY23
G	GLY25
G	ILE27
G	LEU32
G	ALA57
G	GLY59
G	GLY61
G	ILE63
B	LYS94
G	PHE68
G	LYS94
G	GLY96
G	GLY98
G	ILE100
G	LEU105
G	ILE130
G	GLY132
G	GLY134
G	VAL136
B	GLY96
G	PHE141
N	LYS21
N	GLY23
N	GLY25
N	ILE27
N	LEU32
N	ALA57
N	GLY59
N	GLY61
N	ILE63
B	GLY98
N	PHE68
N	LYS94
N	GLY96
N	GLY98
N	ILE100
N	LEU105
N	ILE130
N	GLY132
N	GLY134
N	VAL136
B	ILE100
N	PHE141
O	LYS21
O	GLY23
O	GLY25
O	ILE27
O	LEU32
O	ALA57
O	GLY59
O	GLY61
O	ILE63
B	LEU105
O	PHE68
O	LYS94
O	GLY96
O	GLY98
O	ILE100
O	LEU105
O	ILE130
O	GLY132
O	GLY134
O	VAL136
B	ILE130
O	PHE141
P	LYS21
P	GLY23
P	GLY25
P	ILE27
P	LEU32
P	ALA57
P	GLY59
P	GLY61
P	ILE63
B	GLY132
P	PHE68
P	LYS94
P	GLY96
P	GLY98
P	ILE100
P	LEU105
P	ILE130
P	GLY132
P	GLY134
P	VAL136
B	GLY134
P	PHE141
Q	LYS21
Q	GLY23
Q	GLY25
Q	ILE27
Q	LEU32
Q	ALA57
Q	GLY59
Q	GLY61
Q	ILE63
B	VAL136
Q	PHE68
Q	LYS94
Q	GLY96
Q	GLY98
Q	ILE100
Q	LEU105
Q	ILE130
Q	GLY132
Q	GLY134
Q	VAL136
B	GLY23
B	PHE141
Q	PHE141
R	LYS21
R	GLY23
R	GLY25
R	ILE27
R	LEU32
R	ALA57
R	GLY59
R	GLY61
R	ILE63
C	LYS21
R	PHE68
R	LYS94
R	GLY96
R	GLY98
R	ILE100
R	LEU105
R	ILE130
R	GLY132
R	GLY134
R	VAL136
C	GLY23
R	PHE141
S	LYS21
S	GLY23
S	GLY25
S	ILE27
S	LEU32
S	ALA57
S	GLY59
S	GLY61
S	ILE63
C	GLY25
S	PHE68
S	LYS94
S	GLY96
S	GLY98
S	ILE100
S	LEU105
S	ILE130
S	GLY132
S	GLY134
S	VAL136
C	ILE27
S	PHE141
C	LEU32
C	ALA57
C	GLY59
C	GLY61
C	ILE63
B	GLY25
C	PHE68
C	LYS94
C	GLY96
C	GLY98
C	ILE100
C	LEU105
C	ILE130
C	GLY132
C	GLY134
C	VAL136
B	ILE27
C	PHE141
D	LYS21
D	GLY23
D	GLY25
D	ILE27
D	LEU32
D	ALA57
D	GLY59
D	GLY61
D	ILE63
B	LEU32
D	PHE68
D	LYS94
D	GLY96
D	GLY98
D	ILE100
D	LEU105
D	ILE130
D	GLY132
D	GLY134
D	VAL136
B	ALA57
D	PHE141
E	LYS21
E	GLY23
E	GLY25
E	ILE27
E	LEU32
E	ALA57
E	GLY59
E	GLY61
E	ILE63
B	GLY59
E	PHE68
E	LYS94
E	GLY96
E	GLY98
E	ILE100
E	LEU105
E	ILE130
E	GLY132
E	GLY134
E	VAL136
B	GLY61
E	PHE141
F	LYS21
F	GLY23
F	GLY25
F	ILE27
F	LEU32
F	ALA57
F	GLY59
F	GLY61
F	ILE63
B	ILE63
F	PHE68
F	LYS94
F	GLY96
F	GLY98
F	ILE100
F	LEU105
F	ILE130
F	GLY132
F	GLY134
F	VAL136

site_id	SWS_FT_FI2
Number of Residues	12
Details	MOD_RES: N-acetylalanine => ECO:0000269\|Ref.5

Chain	Residue	Details
B	ASP2
Q	ASP2
R	ASP2
S	ASP2
C	ASP2
D	ASP2
E	ASP2
F	ASP2
G	ASP2
N	ASP2
O	ASP2
P	ASP2

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744\|PubMed:23806337

Chain	Residue	Details
B	ASP22
Q	ASP22
R	ASP22
S	ASP22
C	ASP22
D	ASP22
E	ASP22
F	ASP22
G	ASP22
N	ASP22
O	ASP22
P	ASP22

site_id	SWS_FT_FI4
Number of Residues	12
Details	MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250\|UniProtKB:P0DP29

Chain	Residue	Details
B	GLU45
Q	GLU45
R	GLU45
S	GLU45
C	GLU45
D	GLU45
E	GLU45
F	GLU45
G	GLU45
N	GLU45
O	GLU45
P	GLU45

site_id	SWS_FT_FI5
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P0DP23

Chain	Residue	Details
B	GLU82
Q	GLU82
R	GLU82
S	GLU82
C	GLU82
D	GLU82
E	GLU82
F	GLU82
G	GLU82
N	GLU82
O	GLU82
P	GLU82

site_id	SWS_FT_FI6
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P0DP23

Chain	Residue	Details
B	ASP95
Q	ASP95
R	ASP95
S	ASP95
C	ASP95
D	ASP95
E	ASP95
F	ASP95
G	ASP95
N	ASP95
O	ASP95
P	ASP95

site_id	SWS_FT_FI7
Number of Residues	12
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:18034455, ECO:0007744\|PubMed:21183079

Chain	Residue	Details
B	ILE100
Q	ILE100
R	ILE100
S	ILE100
C	ILE100
D	ILE100
E	ILE100
F	ILE100
G	ILE100
N	ILE100
O	ILE100
P	ILE100

site_id	SWS_FT_FI8
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:21183079

Chain	Residue	Details
B	ALA102
Q	ALA102
R	ALA102
S	ALA102
C	ALA102
D	ALA102
E	ALA102
F	ALA102
G	ALA102
N	ALA102
O	ALA102
P	ALA102

site_id	SWS_FT_FI9
Number of Residues	12
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P0DP23

Chain	Residue	Details
B	ASN111
Q	ASN111
R	ASN111
S	ASN111
C	ASN111
D	ASN111
E	ASN111
F	ASN111
G	ASN111
N	ASN111
O	ASN111
P	ASN111

site_id	SWS_FT_FI10
Number of Residues	12
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250\|UniProtKB:P0DP23

Chain	Residue	Details
B	LEU116
Q	LEU116
R	LEU116
S	LEU116
C	LEU116
D	LEU116
E	LEU116
F	LEU116
G	LEU116
N	LEU116
O	LEU116
P	LEU116

site_id	SWS_FT_FI11
Number of Residues	12
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P0DP23

Chain	Residue	Details
B	GLU139
Q	GLU139
R	GLU139
S	GLU139
C	GLU139
D	GLU139
E	GLU139
F	GLU139
G	GLU139
N	GLU139
O	GLU139
P	GLU139

site_id	SWS_FT_FI12
Number of Residues	24
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250\|UniProtKB:P62157

Chain	Residue	Details
B	ASP22
G	ASP22
N	ASP22
O	ASP22
P	ASP22
Q	ASP22
R	ASP22
S	ASP22
C	ASP22
D	ASP22
E	ASP22
F	ASP22

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)