2DCC

X-ray crystal structure analysis of bovine spleen cathepsin B-CA077 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 801

Chain	Residue
A	PRO2
A	PHE5
A	GLN10
A	SER129
A	TYR165
A	HOH906
A	HOH924
A	HOH937

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site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 77B A 770

Chain	Residue
A	CYS26
A	GLY27
A	SER28
A	CYS29
A	TRP30
A	GLY73
A	GLY74
A	PHE75
A	ALA173
A	PHE174
A	SER175
A	ILE195
A	GLY198
A	GLY198
A	HIS199
A	HOH860
A	HOH926
A	HOH987
A	GLN23

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 500

Chain	Residue
A	ARG8
A	ASP227
A	ASN228
A	LYS232

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Functional Information from PROSITE/UniProt

site_id	PS00139
Number of Residues	12
Details	THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGsCGSCWAfGA

Chain	Residue	Details
A	GLN23-ALA34

---

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. GGHAIRILGWG

Chain	Residue	Details
A	GLY197-GLY207

---

site_id	PS00640
Number of Residues	20
Details	THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvGNSWntdWGdnGFFkI

Chain	Residue	Details
A	TYR214-ILE233

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10088, ECO:0000269|PubMed:10739956, ECO:0000269|PubMed:7106283

Chain	Residue	Details
A	CYS29

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10089, ECO:0000269|PubMed:10739956

Chain	Residue	Details
A	HIS199

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090, ECO:0000269|PubMed:10739956

Chain	Residue	Details
A	ASN219

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P10605

Chain	Residue	Details
A	LYS141

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3379063

Chain	Residue	Details
A	ASN113

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
A	HIS199
A	ASN219
A	CYS29

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
A	HIS199
A	GLN23
A	CYS29

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
A	HIS199
A	ASN219
A	GLN23

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