2DB4
Crystal structure of rotor ring with DCCD of the V- ATPase from Enterococcus hirae
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0015078 | molecular_function | proton transmembrane transporter activity |
| A | 0033177 | cellular_component | proton-transporting two-sector ATPase complex, proton-transporting domain |
| A | 0033179 | cellular_component | proton-transporting V-type ATPase, V0 domain |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046961 | molecular_function | proton-transporting ATPase activity, rotational mechanism |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0015078 | molecular_function | proton transmembrane transporter activity |
| B | 0033177 | cellular_component | proton-transporting two-sector ATPase complex, proton-transporting domain |
| B | 0033179 | cellular_component | proton-transporting V-type ATPase, V0 domain |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046961 | molecular_function | proton-transporting ATPase activity, rotational mechanism |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006814 | biological_process | sodium ion transport |
| C | 0015078 | molecular_function | proton transmembrane transporter activity |
| C | 0033177 | cellular_component | proton-transporting two-sector ATPase complex, proton-transporting domain |
| C | 0033179 | cellular_component | proton-transporting V-type ATPase, V0 domain |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046961 | molecular_function | proton-transporting ATPase activity, rotational mechanism |
| C | 1902600 | biological_process | proton transmembrane transport |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006814 | biological_process | sodium ion transport |
| D | 0015078 | molecular_function | proton transmembrane transporter activity |
| D | 0033177 | cellular_component | proton-transporting two-sector ATPase complex, proton-transporting domain |
| D | 0033179 | cellular_component | proton-transporting V-type ATPase, V0 domain |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046961 | molecular_function | proton-transporting ATPase activity, rotational mechanism |
| D | 1902600 | biological_process | proton transmembrane transport |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0006814 | biological_process | sodium ion transport |
| E | 0015078 | molecular_function | proton transmembrane transporter activity |
| E | 0033177 | cellular_component | proton-transporting two-sector ATPase complex, proton-transporting domain |
| E | 0033179 | cellular_component | proton-transporting V-type ATPase, V0 domain |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0046961 | molecular_function | proton-transporting ATPase activity, rotational mechanism |
| E | 1902600 | biological_process | proton transmembrane transport |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0006811 | biological_process | monoatomic ion transport |
| F | 0006814 | biological_process | sodium ion transport |
| F | 0015078 | molecular_function | proton transmembrane transporter activity |
| F | 0033177 | cellular_component | proton-transporting two-sector ATPase complex, proton-transporting domain |
| F | 0033179 | cellular_component | proton-transporting V-type ATPase, V0 domain |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0046961 | molecular_function | proton-transporting ATPase activity, rotational mechanism |
| F | 1902600 | biological_process | proton transmembrane transport |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0006811 | biological_process | monoatomic ion transport |
| G | 0006814 | biological_process | sodium ion transport |
| G | 0015078 | molecular_function | proton transmembrane transporter activity |
| G | 0033177 | cellular_component | proton-transporting two-sector ATPase complex, proton-transporting domain |
| G | 0033179 | cellular_component | proton-transporting V-type ATPase, V0 domain |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0046961 | molecular_function | proton-transporting ATPase activity, rotational mechanism |
| G | 1902600 | biological_process | proton transmembrane transport |
| H | 0005886 | cellular_component | plasma membrane |
| H | 0006811 | biological_process | monoatomic ion transport |
| H | 0006814 | biological_process | sodium ion transport |
| H | 0015078 | molecular_function | proton transmembrane transporter activity |
| H | 0033177 | cellular_component | proton-transporting two-sector ATPase complex, proton-transporting domain |
| H | 0033179 | cellular_component | proton-transporting V-type ATPase, V0 domain |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0046961 | molecular_function | proton-transporting ATPase activity, rotational mechanism |
| H | 1902600 | biological_process | proton transmembrane transport |
| I | 0005886 | cellular_component | plasma membrane |
| I | 0006811 | biological_process | monoatomic ion transport |
| I | 0006814 | biological_process | sodium ion transport |
| I | 0015078 | molecular_function | proton transmembrane transporter activity |
| I | 0033177 | cellular_component | proton-transporting two-sector ATPase complex, proton-transporting domain |
| I | 0033179 | cellular_component | proton-transporting V-type ATPase, V0 domain |
| I | 0042802 | molecular_function | identical protein binding |
| I | 0046961 | molecular_function | proton-transporting ATPase activity, rotational mechanism |
| I | 1902600 | biological_process | proton transmembrane transport |
| J | 0005886 | cellular_component | plasma membrane |
| J | 0006811 | biological_process | monoatomic ion transport |
| J | 0006814 | biological_process | sodium ion transport |
| J | 0015078 | molecular_function | proton transmembrane transporter activity |
| J | 0033177 | cellular_component | proton-transporting two-sector ATPase complex, proton-transporting domain |
| J | 0033179 | cellular_component | proton-transporting V-type ATPase, V0 domain |
| J | 0042802 | molecular_function | identical protein binding |
| J | 0046961 | molecular_function | proton-transporting ATPase activity, rotational mechanism |
| J | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DCW A 201 |
| Chain | Residue |
| A | ALA136 |
| A | GLU139 |
| A | THR140 |
| A | HOH325 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA A 202 |
| Chain | Residue |
| A | GLN110 |
| A | GLU139 |
| A | LEU61 |
| A | PRO62 |
| A | GLY63 |
| A | THR64 |
| A | GLN65 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LHG A 203 |
| Chain | Residue |
| A | LEU17 |
| A | THR21 |
| A | PHE105 |
| J | PHE101 |
| J | PHE105 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LHG A 204 |
| Chain | Residue |
| A | MET1 |
| A | MET2 |
| A | LEU17 |
| B | LHG204 |
| J | LHG204 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UMQ A 205 |
| Chain | Residue |
| A | GLN54 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UMQ A 206 |
| Chain | Residue |
| A | GLU50 |
| A | PHE52 |
| A | GLY53 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DCW B 201 |
| Chain | Residue |
| B | ALA136 |
| B | GLU139 |
| B | THR140 |
| B | HOH322 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA B 202 |
| Chain | Residue |
| B | LEU61 |
| B | PRO62 |
| B | GLY63 |
| B | THR64 |
| B | GLN65 |
| B | GLN110 |
| B | GLU139 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE LHG B 203 |
| Chain | Residue |
| A | PHE105 |
| B | LEU17 |
| B | THR21 |
| B | PHE105 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LHG B 204 |
| Chain | Residue |
| A | LHG204 |
| B | MET1 |
| B | MET2 |
| B | LEU17 |
| C | LHG204 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DCW C 201 |
| Chain | Residue |
| C | ALA136 |
| C | GLU139 |
| C | THR140 |
| C | HOH314 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA C 202 |
| Chain | Residue |
| C | LEU61 |
| C | PRO62 |
| C | GLY63 |
| C | THR64 |
| C | GLN65 |
| C | GLN110 |
| C | GLU139 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE LHG C 203 |
| Chain | Residue |
| B | PHE105 |
| C | LEU17 |
| C | THR21 |
| C | PHE105 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LHG C 204 |
| Chain | Residue |
| B | LHG204 |
| C | MET1 |
| C | MET2 |
| C | LEU17 |
| D | LHG203 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LHG C 205 |
| Chain | Residue |
| C | PHE101 |
| C | PHE105 |
| D | LEU17 |
| D | THR21 |
| D | PHE105 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE UMQ C 206 |
| Chain | Residue |
| C | GLN54 |
| C | PRO125 |
| C | THR129 |
| F | LYS123 |
| F | PRO125 |
| F | GLU126 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DCW D 201 |
| Chain | Residue |
| D | ALA136 |
| D | GLU139 |
| D | THR140 |
| D | HOH314 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA D 202 |
| Chain | Residue |
| D | LEU61 |
| D | PRO62 |
| D | GLY63 |
| D | THR64 |
| D | GLN65 |
| D | GLN110 |
| D | GLU139 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE LHG D 203 |
| Chain | Residue |
| C | MET2 |
| C | LHG204 |
| D | MET1 |
| D | MET2 |
| D | LEU17 |
| E | LHG203 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE LHG D 204 |
| Chain | Residue |
| D | PHE101 |
| D | PHE105 |
| E | LEU17 |
| E | THR21 |
| E | LEU104 |
| E | PHE105 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UMQ D 205 |
| Chain | Residue |
| D | GLU50 |
| D | PHE52 |
| D | GLY53 |
| D | GLN54 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DCW E 201 |
| Chain | Residue |
| E | ALA136 |
| E | GLU139 |
| E | THR140 |
| E | HOH317 |
| site_id | CC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA E 202 |
| Chain | Residue |
| E | LEU61 |
| E | PRO62 |
| E | GLY63 |
| E | THR64 |
| E | GLN65 |
| E | GLN110 |
| E | GLU139 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE LHG E 203 |
| Chain | Residue |
| D | MET2 |
| D | LHG203 |
| E | MET1 |
| E | MET2 |
| E | LEU17 |
| F | LHG204 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UMQ E 204 |
| Chain | Residue |
| E | GLU50 |
| E | PHE52 |
| E | GLY53 |
| E | GLN54 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DCW F 201 |
| Chain | Residue |
| F | ALA136 |
| F | GLU139 |
| F | THR140 |
| F | HOH320 |
| site_id | CC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA F 202 |
| Chain | Residue |
| F | LEU61 |
| F | PRO62 |
| F | GLY63 |
| F | THR64 |
| F | GLN65 |
| F | GLN110 |
| F | GLU139 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE LHG F 203 |
| Chain | Residue |
| E | PHE105 |
| F | LEU17 |
| F | THR21 |
| F | PHE105 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LHG F 204 |
| Chain | Residue |
| E | LHG203 |
| F | MET1 |
| F | MET2 |
| F | LEU17 |
| G | LHG203 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LHG F 205 |
| Chain | Residue |
| F | PHE101 |
| F | PHE105 |
| G | LEU17 |
| G | THR21 |
| G | PHE105 |
| site_id | DC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE UMQ F 206 |
| Chain | Residue |
| C | LYS123 |
| C | LYS124 |
| C | PRO125 |
| C | GLU126 |
| F | GLN54 |
| F | PRO125 |
| F | GLU126 |
| F | THR129 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DCW G 201 |
| Chain | Residue |
| G | ALA136 |
| G | GLU139 |
| G | THR140 |
| G | HOH324 |
| site_id | DC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA G 202 |
| Chain | Residue |
| G | LEU61 |
| G | PRO62 |
| G | GLY63 |
| G | THR64 |
| G | GLN65 |
| G | GLN110 |
| G | GLU139 |
| site_id | DC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE LHG G 203 |
| Chain | Residue |
| F | MET2 |
| F | LHG204 |
| G | MET1 |
| G | MET2 |
| G | LEU17 |
| H | LHG203 |
| site_id | DC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE LHG G 204 |
| Chain | Residue |
| G | PHE101 |
| G | PHE105 |
| H | LEU17 |
| H | THR21 |
| site_id | DC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DCW H 201 |
| Chain | Residue |
| H | ALA136 |
| H | GLU139 |
| H | THR140 |
| H | HOH332 |
| site_id | EC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA H 202 |
| Chain | Residue |
| H | LEU61 |
| H | PRO62 |
| H | GLY63 |
| H | THR64 |
| H | GLN65 |
| H | GLN110 |
| H | GLU139 |
| site_id | EC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LHG H 203 |
| Chain | Residue |
| G | MET2 |
| G | LHG203 |
| H | MET1 |
| H | MET2 |
| I | LHG204 |
| site_id | EC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UMQ H 204 |
| Chain | Residue |
| H | GLU50 |
| H | GLY53 |
| H | GLN54 |
| site_id | EC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DCW I 201 |
| Chain | Residue |
| I | ALA136 |
| I | GLU139 |
| I | THR140 |
| I | HOH347 |
| site_id | EC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA I 202 |
| Chain | Residue |
| I | LEU61 |
| I | PRO62 |
| I | GLY63 |
| I | THR64 |
| I | GLN65 |
| I | GLN110 |
| I | GLU139 |
| site_id | EC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE LHG I 203 |
| Chain | Residue |
| H | PHE105 |
| I | LEU17 |
| I | THR21 |
| I | PHE105 |
| site_id | EC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LHG I 204 |
| Chain | Residue |
| H | LHG203 |
| I | MET1 |
| I | MET2 |
| I | LEU17 |
| J | LHG204 |
| site_id | EC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UMQ I 205 |
| Chain | Residue |
| I | GLY53 |
| site_id | EC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DCW J 201 |
| Chain | Residue |
| J | ALA136 |
| J | GLU139 |
| J | THR140 |
| J | HOH330 |
| site_id | FC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA J 202 |
| Chain | Residue |
| J | LEU61 |
| J | PRO62 |
| J | GLY63 |
| J | THR64 |
| J | GLN65 |
| J | GLN110 |
| J | GLU139 |
| site_id | FC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LHG J 203 |
| Chain | Residue |
| I | PHE101 |
| I | PHE105 |
| J | LEU17 |
| J | THR21 |
| J | PHE105 |
| site_id | FC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE LHG J 204 |
| Chain | Residue |
| A | LHG204 |
| I | MET2 |
| I | LHG204 |
| J | MET2 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 800 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
