Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2D4E

Crystal Structure of the HpcC from Thermus Thermophilus HB8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001758	molecular_function	retinal dehydrogenase activity
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0006598	biological_process	polyamine catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0018480	molecular_function	5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity
A	0042573	biological_process	retinoic acid metabolic process
A	1901023	biological_process	4-hydroxyphenylacetate catabolic process
B	0000166	molecular_function	nucleotide binding
B	0001758	molecular_function	retinal dehydrogenase activity
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0006598	biological_process	polyamine catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0018480	molecular_function	5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity
B	0042573	biological_process	retinoic acid metabolic process
B	1901023	biological_process	4-hydroxyphenylacetate catabolic process
C	0000166	molecular_function	nucleotide binding
C	0001758	molecular_function	retinal dehydrogenase activity
C	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
C	0006598	biological_process	polyamine catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0018480	molecular_function	5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity
C	0042573	biological_process	retinoic acid metabolic process
C	1901023	biological_process	4-hydroxyphenylacetate catabolic process
D	0000166	molecular_function	nucleotide binding
D	0001758	molecular_function	retinal dehydrogenase activity
D	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
D	0006598	biological_process	polyamine catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0018480	molecular_function	5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity
D	0042573	biological_process	retinoic acid metabolic process
D	1901023	biological_process	4-hydroxyphenylacetate catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 1901

Chain	Residue
A	SER46
A	LEU47
A	ASP113
A	TRP200
A	HOH1932

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 1902

Chain	Residue
B	HOH1907
B	SER46
B	LEU47
B	ASP113
B	TRP200

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA C 1903

Chain	Residue
C	SER46
C	LEU47
C	ASP113
C	TRP200
C	HOH1912

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA D 1904

Chain	Residue
D	SER46
D	LEU47
D	ASP113
D	TRP200
D	HOH1976

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA C 1905

Chain	Residue
C	GLU250
C	NAD1701

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA D 1906

Chain	Residue
D	GLU250
D	NAD1702

site_id	AC7
Number of Residues	32
Details	BINDING SITE FOR RESIDUE NAD C 1701

Chain	Residue
C	ILE169
C	THR170
C	PRO171
C	TRP172
C	LEU178
C	LYS196
C	PRO197
C	ALA198
C	GLU199
C	GLY229
C	GLY233
C	ALA234
C	THR248
C	GLY249
C	GLU250
C	THR253
C	ILE256
C	GLU271
C	LEU272
C	GLY273
C	CYS305
C	GLU409
C	PHE411
C	PHE475
C	NA1905
C	HOH1929
C	HOH2011
C	HOH2016
C	HOH2110
C	HOH2120
C	HOH2151
C	HOH2173

site_id	AC8
Number of Residues	31
Details	BINDING SITE FOR RESIDUE NAD D 1702

Chain	Residue
D	ILE169
D	THR170
D	PRO171
D	TRP172
D	LEU178
D	LYS196
D	PRO197
D	ALA198
D	GLU199
D	GLY229
D	GLY233
D	ALA234
D	THR248
D	GLY249
D	GLU250
D	THR253
D	ILE256
D	GLU271
D	LEU272
D	GLY273
D	CYS305
D	GLU409
D	PHE411
D	PHE475
D	NA1906
D	HOH1924
D	HOH1961
D	HOH2123
D	HOH2131
D	HOH2138
D	HOH2167

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1801

Chain	Residue
A	ILE169
A	GLY229
A	GLY233
A	THR253
A	HOH1907
A	HOH2017

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 1802

Chain	Residue
B	GLY229
B	GLY233
B	THR253
B	HOH1910
B	HOH1943

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 1803

Chain	Residue
C	PRO26
C	LEU28
C	PHE35
C	THR206
C	GLU210
C	ARG25

Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FsFNGERCTASS

Chain	Residue	Details
A	PHE298-SER309

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
A	CYS305
A	ASN173
A	GLU271

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
B	CYS305
B	ASN173
B	GLU271

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
C	CYS305
C	ASN173
C	GLU271

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
D	CYS305
D	ASN173
D	GLU271

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)