2D3G
Double sided ubiquitin binding of Hrs-UIM
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| A | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | SITE: Interacts with activating enzyme |
| Chain | Residue | Details |
| A | ARG54 | |
| A | ARG72 | |
| B | ARG54 | |
| B | ARG72 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Essential for function |
| Chain | Residue | Details |
| A | HIS68 | |
| B | HIS68 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P0CG48 |
| Chain | Residue | Details |
| A | SER65 | |
| B | SER65 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: ADP-ribosylglycine => ECO:0000250|UniProtKB:P0CG48 |
| Chain | Residue | Details |
| A | GLY76 | |
| B | GLY76 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 |
| Chain | Residue | Details |
| A | LYS6 | |
| B | LYS27 | |
| B | LYS29 | |
| B | LYS33 | |
| B | LYS48 | |
| B | LYS63 | |
| A | LYS11 | |
| A | LYS27 | |
| A | LYS29 | |
| A | LYS33 | |
| A | LYS48 | |
| A | LYS63 | |
| B | LYS6 | |
| B | LYS11 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 |
| Chain | Residue | Details |
| A | GLY76 | |
| B | GLY76 |
