2D32
Crystal Structure of Michaelis Complex of gamma-Glutamylcysteine Synthetase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0004357 | molecular_function | glutamate-cysteine ligase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005829 | cellular_component | cytosol |
A | 0006750 | biological_process | glutathione biosynthetic process |
A | 0006972 | biological_process | hyperosmotic response |
A | 0016874 | molecular_function | ligase activity |
A | 0016879 | molecular_function | ligase activity, forming carbon-nitrogen bonds |
A | 0046872 | molecular_function | metal ion binding |
A | 0071243 | biological_process | cellular response to arsenic-containing substance |
A | 0071288 | biological_process | cellular response to mercury ion |
B | 0000166 | molecular_function | nucleotide binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004357 | molecular_function | glutamate-cysteine ligase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0005829 | cellular_component | cytosol |
B | 0006750 | biological_process | glutathione biosynthetic process |
B | 0006972 | biological_process | hyperosmotic response |
B | 0016874 | molecular_function | ligase activity |
B | 0016879 | molecular_function | ligase activity, forming carbon-nitrogen bonds |
B | 0046872 | molecular_function | metal ion binding |
B | 0071243 | biological_process | cellular response to arsenic-containing substance |
B | 0071288 | biological_process | cellular response to mercury ion |
C | 0000166 | molecular_function | nucleotide binding |
C | 0003824 | molecular_function | catalytic activity |
C | 0004357 | molecular_function | glutamate-cysteine ligase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0005829 | cellular_component | cytosol |
C | 0006750 | biological_process | glutathione biosynthetic process |
C | 0006972 | biological_process | hyperosmotic response |
C | 0016874 | molecular_function | ligase activity |
C | 0016879 | molecular_function | ligase activity, forming carbon-nitrogen bonds |
C | 0046872 | molecular_function | metal ion binding |
C | 0071243 | biological_process | cellular response to arsenic-containing substance |
C | 0071288 | biological_process | cellular response to mercury ion |
D | 0000166 | molecular_function | nucleotide binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0004357 | molecular_function | glutamate-cysteine ligase activity |
D | 0005524 | molecular_function | ATP binding |
D | 0005829 | cellular_component | cytosol |
D | 0006750 | biological_process | glutathione biosynthetic process |
D | 0006972 | biological_process | hyperosmotic response |
D | 0016874 | molecular_function | ligase activity |
D | 0016879 | molecular_function | ligase activity, forming carbon-nitrogen bonds |
D | 0046872 | molecular_function | metal ion binding |
D | 0071243 | biological_process | cellular response to arsenic-containing substance |
D | 0071288 | biological_process | cellular response to mercury ion |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 1522 |
Chain | Residue |
A | GLU29 |
A | ASP60 |
A | GLU67 |
A | GLU1519 |
A | ANP1521 |
A | HOH1727 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG A 1523 |
Chain | Residue |
A | ANP1521 |
A | GLU27 |
A | HIS150 |
A | GLU328 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG A 1524 |
Chain | Residue |
A | GLU27 |
A | GLU67 |
A | ANP1521 |
A | HOH1768 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 1525 |
Chain | Residue |
A | ASN442 |
A | ASP444 |
A | HOH1579 |
A | HOH1581 |
A | HOH1708 |
A | HOH1837 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 2522 |
Chain | Residue |
B | GLU29 |
B | ASP60 |
B | GLU67 |
B | GLU2519 |
B | ANP2521 |
B | HOH2568 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG B 2523 |
Chain | Residue |
B | GLU27 |
B | HIS150 |
B | GLU328 |
B | ANP2521 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG B 2524 |
Chain | Residue |
B | GLU27 |
B | GLU67 |
B | ANP2521 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 3522 |
Chain | Residue |
C | GLU29 |
C | ASP60 |
C | GLU67 |
C | GLU3519 |
C | ANP3521 |
C | HOH3594 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG C 3523 |
Chain | Residue |
C | GLU27 |
C | HIS150 |
C | GLU328 |
C | ANP3521 |
site_id | BC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG C 3524 |
Chain | Residue |
C | GLU27 |
C | GLU67 |
C | ANP3521 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG D 4522 |
Chain | Residue |
D | GLU29 |
D | ASP60 |
D | GLU67 |
D | GLU4519 |
D | ANP4521 |
D | HOH4526 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG D 4523 |
Chain | Residue |
D | GLU27 |
D | HIS150 |
D | GLU328 |
D | ANP4521 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG D 4524 |
Chain | Residue |
D | GLU27 |
D | GLU67 |
D | ANP4521 |
D | HOH4711 |
site_id | BC5 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE GLU A 1519 |
Chain | Residue |
A | GLU29 |
A | ASP60 |
A | ILE146 |
A | SER147 |
A | GLY148 |
A | HIS150 |
A | ARG235 |
A | ARG330 |
A | CYS1520 |
A | ANP1521 |
A | MG1522 |
A | HOH1786 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CYS A 1520 |
Chain | Residue |
A | ASP60 |
A | TYR131 |
A | ASN297 |
A | GLU1519 |
A | HOH1828 |
site_id | BC7 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE ANP A 1521 |
Chain | Residue |
A | HOH1768 |
A | HOH1828 |
A | HOH1838 |
A | GLN23 |
A | GLY25 |
A | LEU26 |
A | GLU27 |
A | GLU67 |
A | ILE69 |
A | THR70 |
A | PRO71 |
A | VAL72 |
A | HIS150 |
A | ASN152 |
A | SER154 |
A | LYS306 |
A | GLU325 |
A | TYR326 |
A | GLU328 |
A | ARG330 |
A | GLU1519 |
A | MG1522 |
A | MG1523 |
A | MG1524 |
A | HOH1752 |
site_id | BC8 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE GLU B 2519 |
Chain | Residue |
B | GLU29 |
B | ASP60 |
B | ILE146 |
B | SER147 |
B | GLY148 |
B | HIS150 |
B | ARG235 |
B | TYR241 |
B | ARG330 |
B | CYS2520 |
B | MG2522 |
B | HOH2553 |
B | HOH2566 |
B | HOH2568 |
site_id | BC9 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE CYS B 2520 |
Chain | Residue |
B | ASP60 |
B | TYR131 |
B | ARG132 |
B | GLN144 |
B | TYR241 |
B | ASN297 |
B | GLU2519 |
B | HOH2566 |
B | HOH2671 |
site_id | CC1 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE ANP B 2521 |
Chain | Residue |
B | GLN23 |
B | GLY25 |
B | LEU26 |
B | GLU27 |
B | GLU67 |
B | ILE69 |
B | THR70 |
B | PRO71 |
B | VAL72 |
B | ASN152 |
B | SER154 |
B | LYS306 |
B | GLU325 |
B | TYR326 |
B | GLU328 |
B | MG2522 |
B | MG2523 |
B | MG2524 |
B | HOH2566 |
B | HOH2575 |
B | HOH2610 |
site_id | CC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE GLU C 3519 |
Chain | Residue |
C | GLU29 |
C | ASP60 |
C | ILE146 |
C | SER147 |
C | GLY148 |
C | HIS150 |
C | ARG235 |
C | TYR241 |
C | ARG330 |
C | CYS3520 |
C | MG3522 |
C | HOH3559 |
C | HOH3594 |
site_id | CC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CYS C 3520 |
Chain | Residue |
C | ASP60 |
C | TYR131 |
C | ASN297 |
C | GLU3519 |
C | ANP3521 |
C | HOH3587 |
site_id | CC4 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE ANP C 3521 |
Chain | Residue |
C | GLN23 |
C | GLY25 |
C | LEU26 |
C | GLU27 |
C | GLU67 |
C | ILE69 |
C | THR70 |
C | PRO71 |
C | VAL72 |
C | ASN152 |
C | PHE153 |
C | SER154 |
C | LYS306 |
C | GLU325 |
C | TYR326 |
C | GLU328 |
C | CYS3520 |
C | MG3522 |
C | MG3523 |
C | MG3524 |
C | HOH3590 |
C | HOH3600 |
site_id | CC5 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE GLU D 4519 |
Chain | Residue |
D | GLU29 |
D | ASP60 |
D | ILE146 |
D | SER147 |
D | GLY148 |
D | HIS150 |
D | ARG235 |
D | TYR241 |
D | ARG330 |
D | CYS4520 |
D | ANP4521 |
D | MG4522 |
D | HOH4526 |
D | HOH4665 |
D | HOH4691 |
site_id | CC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CYS D 4520 |
Chain | Residue |
D | ASP60 |
D | TYR131 |
D | ARG132 |
D | GLU4519 |
D | ANP4521 |
D | HOH4691 |
site_id | CC7 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE ANP D 4521 |
Chain | Residue |
D | GLN23 |
D | GLY25 |
D | LEU26 |
D | GLU27 |
D | GLU67 |
D | ILE69 |
D | THR70 |
D | PRO71 |
D | VAL72 |
D | ASN152 |
D | SER154 |
D | LYS306 |
D | GLU325 |
D | TYR326 |
D | GLU328 |
D | GLU4519 |
D | CYS4520 |
D | MG4522 |
D | MG4523 |
D | MG4524 |
D | HOH4647 |
D | HOH4652 |
D | HOH4695 |