Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 257 |
| Chain | Residue |
| A | HIS201 |
| A | HIS205 |
| A | HIS211 |
| A | FA41001 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 258 |
| Chain | Residue |
| A | HIS151 |
| A | ASP153 |
| A | HIS166 |
| A | HIS179 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 259 |
| Chain | Residue |
| A | GLY159 |
| A | GLY161 |
| A | VAL163 |
| A | ASP181 |
| A | GLU184 |
| A | ASP158 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 260 |
| Chain | Residue |
| A | ASP107 |
| A | ASP182 |
| A | GLU184 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 261 |
| Chain | Residue |
| A | ASP141 |
| A | GLY173 |
| A | ASN175 |
| A | ASP177 |
| A | HOH1022 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 262 |
| Chain | Residue |
| B | HIS201 |
| B | HIS205 |
| B | HIS211 |
| B | FA41002 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 263 |
| Chain | Residue |
| B | HIS151 |
| B | ASP153 |
| B | HIS166 |
| B | HIS179 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 264 |
| Chain | Residue |
| B | ASP158 |
| B | GLY159 |
| B | GLY161 |
| B | VAL163 |
| B | ASP181 |
| B | GLU184 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA B 265 |
| Chain | Residue |
| B | ASP107 |
| B | ASP182 |
| B | GLU184 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 266 |
| Chain | Residue |
| B | ASP141 |
| B | GLY173 |
| B | ASN175 |
| B | ASP177 |
| B | HOH1005 |
| B | HOH1010 |
| site_id | BC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE FA4 A 1001 |
| Chain | Residue |
| A | ASN162 |
| A | VAL163 |
| A | LEU164 |
| A | ALA165 |
| A | HIS201 |
| A | GLU202 |
| A | HIS205 |
| A | HIS211 |
| A | THR215 |
| A | ALA217 |
| A | LEU218 |
| A | TYR220 |
| A | LEU222 |
| A | TYR223 |
| A | ZN257 |
| A | HOH1005 |
| A | HOH1034 |
| B | HIS224 |
| site_id | BC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE FA4 B 1002 |
| Chain | Residue |
| A | HIS224 |
| B | ASN162 |
| B | VAL163 |
| B | LEU164 |
| B | ALA165 |
| B | HIS201 |
| B | GLU202 |
| B | HIS205 |
| B | HIS211 |
| B | THR215 |
| B | ALA217 |
| B | LEU218 |
| B | TYR220 |
| B | LEU222 |
| B | TYR223 |
| B | ZN262 |
| B | HOH1006 |
| B | HOH1030 |
| B | HOH1046 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEIGHSL |
| Chain | Residue | Details |
| A | VAL198-LEU207 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | GLU202 | |
| B | GLU202 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP107 | |
| A | GLY173 | |
| A | ASN175 | |
| A | ASP177 | |
| A | HIS179 | |
| A | ASP181 | |
| A | ASP182 | |
| A | GLU184 | |
| B | ASP107 | |
| B | ASP141 | |
| B | HIS151 | |
| A | ASP141 | |
| B | ASP153 | |
| B | ASP158 | |
| B | GLY159 | |
| B | GLY161 | |
| B | VAL163 | |
| B | HIS166 | |
| B | GLY173 | |
| B | ASN175 | |
| B | ASP177 | |
| B | HIS179 | |
| A | HIS151 | |
| B | ASP181 | |
| B | ASP182 | |
| B | GLU184 | |
| A | ASP153 | |
| A | ASP158 | |
| A | GLY159 | |
| A | GLY161 | |
| A | VAL163 | |
| A | HIS166 | |
| Chain | Residue | Details |
| A | HIS201 | |
| A | HIS205 | |
| A | HIS211 | |
| B | HIS201 | |
| B | HIS205 | |
| B | HIS211 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 591 |
| Chain | Residue | Details |
| A | HIS201 | metal ligand |
| A | GLU202 | proton acceptor, proton donor |
| A | HIS205 | metal ligand |
| A | HIS211 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 591 |
| Chain | Residue | Details |
| B | HIS201 | metal ligand |
| B | GLU202 | proton acceptor, proton donor |
| B | HIS205 | metal ligand |
| B | HIS211 | metal ligand |
